Identifiers
catenin (cadherin-associated protein), beta 1, 88kDa
HUGO:CTNNB1, HGNC:2514, ENTREZ:1499, UNIPROT:P35222, GENECARDS:GC03P041236
HUGO:CTNNB1
"catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB
HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222
HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1
catenin (cadherin-associated protein) beta 1
armadillo, beta-catenin

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence   / EMT_REGULATORS 
 EMT Senescence   / CELL_CELL_ADHESIONS 
 EMT Senescence   / ADHERENS_JUNCTIONS 
 EMT Senescence   / LYSOSOME_ENDOSOME 
HMC:TUMOR_PROMOTING_INFLAMMATION
 Innate Immunity   / MIRNA_TF_IMMUNOSUPPRESSIVE 
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival   / MAPK 
 Survival   / HEDGEHOG 
 Survival   / WNT_CANONICAL 
 Survival   / WNT_NON_CANONICAL 

References
PMID:7542250
Whereas in the normal cells CTNNB1 (beta-catenin) is found in association with E-cadherin, p120 Cas is not. In the ras-transformed cells, the situation is reversed; tyrosine-phosphorylated p120 Cas, but not tyrosine-phosphorylated CTNNB1, now is detected in E-cadherin complexes.
The tyrosine-phosphorylated CTNNB1 also shows increased detergent solubility, suggesting a decreased association with the actin cytoskeleton.
decreased tyrosine phosphorylation of CTNNB1 is accompanied by increased interaction with both E-cadherin and the detergent insoluble cytoskeletal fraction
PMID:12051714
Activation of the canonical Wnt signalling pathway results in stabilisation and nuclear translocation of b-catenin.
In the absence of a Wnt signal, b-catenin is phosphorylated at four conserved serine and threonine residues at the N-terminus of the protein, which results in b-catenin ubiquitination and proteasome-dependent degradation.
The phosphorylation of 3 of these residues, Thr41, Ser37, and Ser33, is mediated by glycogen synthase kinase-3 (GSK-3) in a sequential manner, beginning from the C-terminal Thr41.
It has been shown that the GSK-3 dependent phosphorylation of b-catenin requires prior priming through phosphorylation of Ser45
GSK-3b was found to be unable to phosphorylate b-catenin at Ser45 in vitro and in intact cells.
In vitro, CK1, but not CK2, phosphorylates Ser45. Ser45 phosphorylation in intact cells is not mediated by CK1e, a known positive regulator of Wnt signalling.
PMID:11955436
Wnt regulation of b-catenin degradation is essential for development and carcinogenesis.
b-catenin degradation is initiated upon amino-terminal serine/threonine phosphorylation.
This phosphorylation is believed to be performed by GSK3B in complex with tumor suppressor proteins Axin and APC.
There is another Axin-associated kinase, whose phosphorylation of b-catenin precedes and is required for subsequent GSK-3 phosphorylation of b-catenin.
This priming kinase is casein kinase I, alpha (CSNK1A1).
PMID:11967263
Tyr-216 phosphorylation in GSK3B is required for GSK-mediated down-regulation of b-catenin activity.
PMID:8666229
Xenopus GSK3 functions to destabilize b-catenin and thus decrease the amount of b-catenin available for signaling
 DENDRITIC_CELL 
CASCADE:CATENINB
PMID:24023259
??-Catenin mediates tumor-induced immunosuppression by inhibiting cross-priming of CD8+ T cells
PMID:25730849
L-10 Mediates ??-Catenin???Dependent Inhibition of Cross-Priming,??-catenin enhanced IL-10 induction through mTOR pathway.
??-Catenin up-regulates level of mTOR in DCs and activates mTOR signaling.
PMID:20705860
??-catenin signaling in DCs is required to induce Treg cells and suppress TH1/TH17 responses.
??-catenin signaling in intestinal DCs promotes the expression of Raldh and suppresses the expression of proinflammatory cytokines (IL6, IL23a,IL12p40)
but induces IL10 production.
PMID:15001769, PMID:17936032
GSK3B phosphorylates beta-catenin and inhibits its activity.
Beta-catenin signaling prevents production of inflammatory cytokines IL6, IL-1??, IL-6, TNF-??, and IL-12 p40,
But upregulates CCR7, both at the mRNA level and on the plasma membrane.
CCR7 is a chemokine receptor important for the migration of DCs from the periphery to T cell areas of lymph nodes.
DCs matured by CD activation of beta-catenin signaling alone failed to prime CD4 T cells to produce IFN-?? but did generate high levels of IL10 (Fig. 6A) together with other cytokines (not shown) consistent with type I regulatory T cells
ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex.
Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled).
PMID:16039586 PMID:16039586
PMID:19619488
PMID:17143292
PMID:23343194

References
em_emtc_emtc_re527( EMT Senescence  ):
PMID:19751508
PMID:22270359
PMID:16940750
-In the absence of Wnt ligands, b-catenin is phosphorylated by CK1 and GSK-3 in the context of a destruction complex with APC and Axin.
Phosphorylated b-catenin is consequently targeted for ubiquitination and degraded.
-In the presence of Wnt lignads, upon ligand binding, DVL1 (dishevelled) recruits the Axin-GSK-3 complex, resulting in the sequential phosphorylation of LRP6 by CK1 and GSK-3.
Phoshorylated LRP6 serves as a docking site for additional Axin-GSK-3 complex, resulting in the disassembly of the destruction complex.
Non phosphorylated and thus stabilized b-catenin translocates to the nucleus where it activates transcription of target genes together with LEF/TCFs
PMID:19020303
When Wnt binds its receptor, Frizzled, beta-catenin is released to translocate from the cytoplasm to the nucleus, where it forms a complex with TCF and/or LEF transcription factors and stimulates cyclin D1 gene transcription
(Beta-catenin/TCF)- mediated cyclin D1 gene transcription is further regulated by active Rac signaling, phosphorylation by protein kinase A (PKA)
PMID:15377999
Rac1-GTP augments nuclear accumulation of b-catenin and physical association of Rac1 with b-catenin and/or TCF-4 may facilitate this process.
This culminates in the amplification of b-catenin signaling activity, resulting in enhanced transcriptional activation of perhaps a specific subset of Wnt target genes important in cancer progression.
PMID:15082531
The activation of MP3K7(TAK1) by TAB1 activates NLK. the TAK1???NLK MAPK pathway regulates Wnt signaling by phosphorylating TCF in mammalian cells.
NLK phosphorylates TCF/LEF factors and inhibits the interaction of the beta-catenin???TCF complex with DNA.
em_emtc_emtc_re1010( EMT Senescence  ):
PMID:10593980
PMID:12123611
Phosphorylation of CTNNB1 at Y654 by SRC prevents the interaction between Cadherin and CTNNB1.
This phosphorylation therefore reduces adhesive function.
em_emtc_emtc_re1022( EMT Senescence  ):
PMID:15609097
CTNNB1 (beta-catenin) binds with high affinity to the distal Cadherin cytoplasmic tail.
Cadherin recruits CTNNA1 (alpha-catenin) to the complex.
CTNNA1 (alpha-catenin) binds to Actin filaments directly
CTNNA1 (alpha-catenin) and can also associate with other actin-binding proteins (MLLT4 or Formin)
CTNND1 (delta-catenin or p120) binds directly to Cadherin independently of the other catenins.
Catenins/Cadherin complex can further interact with a range of singaling molecules which participate in either cellular signaling or control of cytoskeletal dynamics.
Stability of Cadherin/Catenins complex and thereby the integrity of adherens junctions is controlled by phosphorylation/dephosphorylation.
em_emtc_emtc_re1328:( EMT Senescence  ) PMID:21841793

References
em_emtc_emtc_re1010( EMT Senescence  ):
PMID:10593980
PMID:12123611
Phosphorylation of CTNNB1 at Y654 by SRC prevents the interaction between Cadherin and CTNNB1.
This phosphorylation therefore reduces adhesive function.

References
em_re1455( EMT Senescence  ):
PMID??:10402472
We conclude that a pool of surface E-cadherin is constantly trafficked through an endocytic, recycling pathway and that this may provide a mechanism for regulating the availability of E-cadherin for junction formation in development, tissue remodeling, and tumorigenesis.

References
su_mpk1_mpk1_re106( Survival  ):
Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled).
PMID:16039586
su_shh1_s_shh2_re119:( Survival  ) PMID:17297467
su_mpk1_mpk1_re107( Survival  ):
In the presence of wnt signals (+wnt) the cytosolic amount of b-catenin increases and thus translocates to the nucleus where it associates with transcription factors of the TCF/ LEF family. Due to its transactivating ability the b-catenin-transcription-factor-co mplex binds to DNA and activates wnt target genes.
http://www.gene-regulation.com/info/b-catenin.html

References
su_wnc1_s_wnc4_re31( Survival  ):
binding of G-alpha12 toE-cadherin results of loss of binding of b-catenin from the adherence junction
PMID:11136230
su_wca1_s_wca3_re74:( Survival  ) PMID:20508033
su_mpk1_mpk1_re105( Survival  ):
Phosphorylation of beta-catenin (CTNNB1) by GSK-3beta (GSK3B) causes its degradation
PMID:16039586
su_mpk1_mpk1_re106( Survival  ):
Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled).
su_wnc1_s_wnc1_re2( Survival  ):
PMID:21506126
Phosphorylation of beta-catenin is through an indirect mechanism which is unknown
PMID:21303971
Path to phosphorylation of b-catenin is not completely depicted here. For full paths see AKT-MODULE
su_wnc1_s_wnc2_re4( Survival  ):
PMID:21506126, PMID:21303971
Path to phosphorylation of b-catenin is not completely depicted here. For full paths see AKT-pathway
Activated CaSR inhibits phosphorylation of b-catenin, exact mechanism unknown
PMID:22094462
su_wnc1_s_wnc4_re24( Survival  ):
Complex of G-alpha12 and p120 stabilises binding of E-cadherin in Adhesion-complex. G-alpha12 is found back in complex with p120 and E-cadherin
PMID:15240885
su_wca1_s_wca1_re1:( Survival  ) PMID:17143292
su_wca1_s_wca2_re1:( Survival  ) PMID:21490931
su_wca1_s_wca2_re40:( Survival  ) PMID:22203675
su_wca1_s_wca2_re51:( Survival  ) PMID:21152425 PMID:19244247
su_wca1_s_wca2_re62:( Survival  ) PMID:22705350
su_wca1_s_wca3_re3( Survival  ):
Upon wnt signalling beta-catenin is not degraded and can enter the nucleus
BCL9 and PYGO stimulate translocation of b-catenin.
PMID:15208637
No active transport of b-catenin localisation of b-catenin by retention of the binding partners
PMID:16554443
su_wca1_s_wca4_re1:( Survival  ) PMID:22699938

References
su_mpk1_mpk1_re105( Survival  ):
Phosphorylation of beta-catenin (CTNNB1) by GSK-3beta (GSK3B) causes its degradation
PMID:16039586
su_wca1_s_wca2_re51:( Survival  ) PMID:21152425 PMID:19244247
su_wca1_s_wca2_re50:( Survival  ) PMID:22659456 PMID:22007144 PMID:19171760 PMID:10931041

References
s_wnc1_re2( Survival  ):
PMID:21506126
Phosphorylation of beta-catenin is through an indirect mechanism which is unknown
PMID:21303971
Path to phosphorylation of b-catenin is not completely depicted here. For full paths see AKT-MODULE

References
s_wnc1_re17:( Survival  ) PMID:21303971
s_wnc1_re3( Survival  ):
PMID:21506126
This phosphorylated of b-catenin bypasses the canonical wnt-MODULE and enters directly the nucleus where it is transcriptionally active
PMID:16476742

References
s_wnc1_re3( Survival  ):
PMID:21506126
This phosphorylated of b-catenin bypasses the canonical wnt-MODULE and enters directly the nucleus where it is transcriptionally active
PMID:16476742
s_wnc1_re52( Survival  ):
This phosphorylated form of b-catenin facilitates interaction between b-catenin and CBP
su_wnc1_s_wnc1_re52( Survival  ):

References
s_wnc2_re4( Survival  ):
PMID:21506126, PMID:21303971
Path to phosphorylation of b-catenin is not completely depicted here. For full paths see AKT-pathway
Activated CaSR inhibits phosphorylation of b-catenin, exact mechanism unknown
PMID:22094462

References
s_wnc4_re5:( Survival  ) PMID:16099633
s_wnc4_re7( Survival  ):
B-catenin phosphorylated at this residues shows increased binding with Bcl9 (mouse homologue Bcl9-2)
PMID:15371335
Apperently Bcl9 binds b-catenin independently of Y142
PMID:17113272

References
s_wca1_re49:( Survival  ) PMID:19576224

Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival   / WNT_CANONICAL 

Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival   / WNT_CANONICAL 

References
s_wca2_re40:( Survival  ) PMID:22203675
s_wca2_re69:( Survival  ) PMID:22370635
s_wca2_re42( Survival  ):
Degradation by GSK3/AXIN (destruction complex) is the same as for the canonical-isoform of beta-catenin (no PTM)
PMID:22203675

Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival   / WNT_CANONICAL 

References
s_wca2_re42( Survival  ):
Degradation by GSK3/AXIN (destruction complex) is the same as for the canonical-isoform of beta-catenin (no PTM)
PMID:22203675
s_wca2_re47:( Survival  ) PMID:19104148

Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival   / WNT_CANONICAL 

References
s_wca2_re62:( Survival  ) PMID:22705350
s_wca2_re63( Survival  ):
Ubiquination at this residue increases b-catenin protein stability and increased top-flash activity
PMID:22705350

Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival   / WNT_CANONICAL 

References
s_wca2_re67:( Survival  ) PMID:22370635

References
su_wca1_s_wca3_re3( Survival  ):
Upon wnt signalling beta-catenin is not degraded and can enter the nucleus
BCL9 and PYGO stimulate translocation of b-catenin.
PMID:15208637
No active transport of b-catenin localisation of b-catenin by retention of the binding partners
PMID:16554443
su_wca1_s_wca3_re15( Survival  ):
Acetylation of beta-catenin increases its stability
PMID:18987336
su_wca1_s_wca3_re67:( Survival  ) PMID:19000719
su_wca1_s_wca3_re73:( Survival  ) PMID:19383900
su_wca1_s_wca3_re88:( Survival  ) PMID:10984057 PMID:11263497
su_wca1_s_wca3_re144( Survival  ):
This complex does not contain HDAC but do contain LEF1
PMID:17666529
su_wca1_s_wca3_re149( Survival  ):
HIPK2 phosphorylates S33 and S37 residues as GSK3 without priming b-catenin first
PMID:20307497

References
s_wca3_re15( Survival  ):
Acetylation of beta-catenin increases its stability
PMID:18987336

References
s_wca3_re149( Survival  ):
HIPK2 phosphorylates S33 and S37 residues as GSK3 without priming b-catenin first
PMID:20307497

References
s_shh2_re119:( Survival  ) PMID:17297467

References
s_wca3_re74:( Survival  ) PMID:20508033
s_wnc4_re31( Survival  ):
binding of G-alpha12 toE-cadherin results of loss of binding of b-catenin from the adherence junction
PMID:11136230
s_shh2_re119:( Survival  ) PMID:17297467
s_mpk1_re105( Survival  ):
Phosphorylation of beta-catenin (CTNNB1) by GSK-3beta (GSK3B) causes its degradation
PMID:16039586
s_mpk1_re106( Survival  ):
Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled).
s_wca1_re1:( Survival  ) PMID:17143292
s_wca2_re1:( Survival  ) PMID:21490931
s_wca2_re40:( Survival  ) PMID:22203675
s_wca2_re51:( Survival  ) PMID:21152425 PMID:19244247
s_wca2_re62:( Survival  ) PMID:22705350
s_wca3_re3( Survival  ):
Upon wnt signalling beta-catenin is not degraded and can enter the nucleus
BCL9 and PYGO stimulate translocation of b-catenin.
PMID:15208637
No active transport of b-catenin localisation of b-catenin by retention of the binding partners
PMID:16554443
s_wca4_re1:( Survival  ) PMID:22699938
s_wnc1_re2( Survival  ):
PMID:21506126
Phosphorylation of beta-catenin is through an indirect mechanism which is unknown
PMID:21303971
Path to phosphorylation of b-catenin is not completely depicted here. For full paths see AKT-MODULE
s_wnc2_re4( Survival  ):
PMID:21506126, PMID:21303971
Path to phosphorylation of b-catenin is not completely depicted here. For full paths see AKT-pathway
Activated CaSR inhibits phosphorylation of b-catenin, exact mechanism unknown
PMID:22094462
s_wnc4_re24( Survival  ):
Complex of G-alpha12 and p120 stabilises binding of E-cadherin in Adhesion-complex. G-alpha12 is found back in complex with p120 and E-cadherin
PMID:15240885

1. _beta_-Catenin*@Clathrin coated vesicle

1. _beta_-Catenin*@Cytoplasm
2. _beta_-Catenin*@Cytoplasm
3. _beta_-Catenin*@Cytoplasm
4. _beta_-Catenin*@Cytoplasm
5. _beta_-Catenin*@Cytoplasm
6. _beta_-Catenin*@Cytoplasm
7. _beta_-Catenin*@Cytoplasm
8. _beta_-Catenin*@Cytoplasm
9. _beta_-Catenin*|​pho@Cytoplasm
10. _beta_-Catenin*|​pho@Cytoplasm
11. _beta_-Catenin*|​K394_ubi@Cytoplasm
12. _beta_-Catenin*|​S522_pho@Cytoplasm
13. _beta_-Catenin*|​S552_pho@Cytoplasm
14. _beta_-Catenin*|​Y142_pho@Cytoplasm
15. _beta_-Catenin*|​Y654_pho@Cytoplasm
16. _beta_-Catenin*|​S552_pho|​pho@Cytoplasm
17. _beta_-Catenin*|​S522_pho|​S675_pho@Cytoplasm
18. _beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho|​K19_ubi|​K49_ubi@Cytoplasm

1. _beta_-Catenin*@Cytosol
2. _beta_-Catenin*|​pho@Cytosol

1. _beta_-Catenin*@Endosome

1. _beta_-Catenin*@Extracellular space

1. _beta_-Catenin*@INNATE_IMMUNE_CELL_Cytosol
2. _beta_-Catenin*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol

1. _beta_-Catenin*@Lysosome

1. _beta_-Catenin*@Neighbouring Cell

1. _beta_-Catenin*@Nucleus
2. _beta_-Catenin*@Nucleus
3. _beta_-Catenin*@Nucleus
4. _beta_-Catenin*|​ace@Nucleus
5. _beta_-Catenin*|​Y654_pho@Nucleus
6. _beta_-Catenin*|​pho|​pho@Nucleus
7. _beta_-Catenin*|​S522_pho|​S675_pho@Nucleus

1. _beta_-Catenin*@Protrusion

1. JBN*:​_beta_-Catenin*@Cilium

1. APC:​_beta_-Catenin*@Cytoplasm
2. JBN*:​_beta_-Catenin*@Cytoplasm
3. NKD1:​_beta_-Catenin*@Cytoplasm
4. Kindlin2*:​_beta_-Catenin*@Cytoplasm
5. APC|​S2034_pho:​_beta_-Catenin*@Cytoplasm
6. APC|​T1487_pho:​_beta_-Catenin*|​K345_ace|​ace@Cytoplasm
7. E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho:​ITGA9:​_beta_-Catenin*|​pho@Cytoplasm
8. E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho:​ITGA9:​_beta_-Catenin*|​Y654_pho|​pho@Cytoplasm
9. Cytoskeleton:​E-Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*:​p120*@Cytoplasm
10. Cytoskeleton:​E-Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*|​Y142_pho:​p120*@Cytoplasm
11. E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho:​ITGA3:​TGFB1:​TGFBR*:​_beta_-Catenin*|​pho:​p120*@Cytoplasm
12. Cytoskeleton:​E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho:​ECM or cell-cell contact:​ITGA3:​_alpha_-Catenin*:​_beta_-Catenin*|​pho:​p120*@Cytoplasm
13. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*@Cytoplasm
14. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho@Cytoplasm
15. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho@Cytoplasm
16. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho@Cytoplasm
17. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm
18. AMER1*:​APC|​S1505_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm
19. AMER1*:​APC|​S1505_pho|​S1501_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm
20. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm
21. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm
22. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm
23. APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PP2A_C*:​PR55_alpha_*:​PR65_A*:​_beta_-Catenin*|​S45_emp|​T41_emp|​S37_emp|​S33_emp@Cytoplasm
24. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PP2A_C*:​PR55_alpha_*:​PR65_A*:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm
25. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​CK2_alpha_'*:​CK2_alpha_*:​CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​CUL1:​E1*:​FAF*:​GSK3*:​NEDD8:​PKD*:​PtdIns(4,5)-P2:​RAD6*:​RBX1:​SKP*:​USP15:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho|​K19_ubi|​K49_ubi:​_beta_TRCP*@Cytoplasm

1. Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*@Cytosol
2. APC|​pho:​AXIN1|​pho:​_beta_-Catenin*@Cytosol
3. APC|​pho:​AXIN1|​pho:​_beta_-Catenin*|​pho@Cytosol
4. APC|​pho:​AXIN1|​pho:​_beta_-Catenin*|​pho|​pho|​pho|​pho@Cytosol
5. Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*:​p120*@Cytosol

1. E-Cadherin*:​ITGA3:​TGFB1:​TGFBR*:​_beta_-Catenin*|​pho:​p120*@Endosome
2. E-Cadherin*:​ITGA3:​TGFB1:​TGFBR*:​_beta_-Catenin*|​Y654_pho|​pho:​p120*@Endosome

1. E-Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*@INNATE_IMMUNE_CELL_Cytosol

1. JAG1|​ubi:​NOTCH1:​NUMB:​_beta_-Catenin*@Lysosome

1. LEF1_TCF3_4*:​_beta_-Catenin*@Nucleus
2. SMAD2|​pho:​_beta_-Catenin*|​Y654_pho@Nucleus
3. APC|​T1487_pho:​_beta_-Catenin*|​K345_ace|​ace@Nucleus
4. BCL9:​PYGO*:​_beta_-Catenin*|​ace@Nucleus
5. BCL9:​PYGO*:​_beta_-Catenin*|​K345_ace|​ace@Nucleus
6. BCL9:​PYGO*:​_beta_-Catenin*|​K345_ace|​ace@Nucleus
7. BCL9:​CBP*|​S92_pho:​PYGO*:​_beta_-Catenin*|​ace|​ace@Nucleus
8. BCL9:​KLF8|​K67_ace|​K93_ace|​K95_ace:​PYGO*:​_beta_-Catenin*|​K345_ace|​ace@Nucleus
9. BCL9:​PYGO*:​SMAD1|​pho:​TCF4:​_beta_-Catenin*|​K345_ace|​ace@Nucleus
10. BCL9:​DVL*:​JUN|​pho|​pho:​PYGO*:​_beta_-Catenin*|​K345_ace|​ace@Nucleus
11. BCL9:​CTBP*:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​ace@Nucleus
12. BCL9:​CBP*|​S92_pho:​DVL*:​JUN|​pho|​pho:​PYGO*:​_beta_-Catenin*|​ace|​ace@Nucleus
13. BCL9:​KLF8|​K67_ace|​K93_ace|​K95_ace:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace@Nucleus
14. BCL9:​DVL*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace@Nucleus
15. BCL9:​CBP*|​S92_pho:​DVL*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_emp|​ace|​ace@Nucleus
16. APC|​T1487_pho:​BCL9:​CTBP*|​hm2:​DVL*:​HDAC1_2*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace@Nucleus

1. _beta_-Catenin*@Cytosol → _beta_-Catenin*|​pho@Cytosol
2. _beta_-Catenin*@Cytosol + (APC|​pho:​AXIN1|​pho)|​active@Cytosol → APC|​pho:​AXIN1|​pho:​_beta_-Catenin*@Cytosol
3. Catenin*@Cytosol → _beta_-Catenin*@Cytosol
4. _beta_-Catenin*@Cytosol + Cadherin*@Cytosol + _alpha_-Catenin*@Cytosol → Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*@Cytosol
5. _beta_-Catenin*_p120*1_Plakoglobin*_Plakophilin4*@Cytosol → _beta_-Catenin*@Cytosol
6. Plakophilin2 binding partners*@Cytosol → _beta_-Catenin*@Cytosol
7. Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*@Cytosol + Cadherin*:​p120*@Cytosol + Actin cytoskeletal*@Cytosol → Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*:​p120*@Cytosol
8. r_beta_-Catenin*@Nucleus → _beta_-Catenin*@Cytosol
9. JAG1|​ubi:​NOTCH1@Neighbouring Cell + _beta_-Catenin*@Cytosol + NUMB@Cytosol → JAG1|​ubi:​NOTCH1:​NUMB:​_beta_-Catenin*@Lysosome
10. NICD co-factors*@Nucleus → _beta_-Catenin*@Cytosol
11. Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*:​p120*@Cytosol → E-Cadherin*|​Y_pho@Cytosol
12. APC|​pho:​AXIN1|​pho:​_beta_-Catenin*|​pho@Cytosol → APC|​pho:​AXIN1|​pho:​_beta_-Catenin*|​pho|​pho|​pho|​pho@Cytosol
13. APC|​pho:​AXIN1|​pho:​_beta_-Catenin*|​pho|​pho|​pho|​pho@Cytosol → degraded
14. APC|​pho:​AXIN1|​pho:​_beta_-Catenin*@Cytosol → APC|​pho:​AXIN1|​pho:​_beta_-Catenin*|​pho@Cytosol
15. LEF1_TCF3_4*@Nucleus + _beta_-Catenin*@Cytosol → LEF1_TCF3_4*:​_beta_-Catenin*@Nucleus
16. Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*:​p120*@Cytosol → Adherens junctions@Cytosol
17. Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*:​p120*@Cytosol → _alpha_-Catenin*@Clathrin coated vesicle
18. Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*:​p120*@Cytosol → E-Cadherin*@Clathrin coated vesicle
19. Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*:​p120*@Cytosol → _beta_-Catenin*@Clathrin coated vesicle
20. Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*:​p120*@Cytosol → p120*@Clathrin coated vesicle
21. _beta_-Catenin*@Clathrin coated vesicle → _beta_-Catenin*@Endosome
22. _beta_-Catenin*@Endosome → _beta_-Catenin*@Lysosome
23. _beta_-Catenin*@Lysosome → degraded
24. Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*:​p120*@Cytosol → E-Cadherin*@Caveolin vesicle
25. Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*:​p120*@Cytosol → E-Cadherin*@Macropinosome
26. Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*:​p120*@Cytosol → degraded
27. _beta_-Catenin*@INNATE_IMMUNE_CELL_Cytosol → _beta_-Catenin*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol
28. _beta_-Catenin*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol → degraded
29. E-Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*@INNATE_IMMUNE_CELL_Cytosol → _beta_-Catenin*@INNATE_IMMUNE_CELL_Cytosol + E-Cadherin*@INNATE_IMMUNE_CELL_Cytosol + _alpha_-Catenin*@INNATE_IMMUNE_CELL_Cytosol
30. _beta_-Catenin*@Cytoplasm → _beta_-Catenin*|​pho@Cytoplasm
31. _beta_-Catenin*@Cytoplasm → _beta_-Catenin*@Nucleus
32. _beta_-Catenin*@Nucleus + LEF_TCF*@Nucleus → su_mpk1_mpk1_s1019
33. LEF_TCF*@Nucleus + _beta_-Catenin*@Nucleus + gpromoter_region@Nucleus → LEF_TCF*:​promoter_region@Nucleus
34. _beta_-Catenin*@Nucleus + GLI3-83_sub_TRUNC_endsub_*@Nucleus → su_shh1_s_shh2_s195
35. _beta_-Catenin*@Extracellular space → _beta_-Catenin*@Nucleus
36. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2@Cytoplasm + _beta_-Catenin*@Cytoplasm → AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*@Cytoplasm
37. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm → AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm
38. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*@Cytoplasm → AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho@Cytoplasm
39. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm + PP2A_C*:​PR55_alpha_*:​PR65_A*@Cytoplasm → AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PP2A_C*:​PR55_alpha_*:​PR65_A*:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm
40. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PP2A_C*:​PR55_alpha_*:​PR65_A*:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm → APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PP2A_C*:​PR55_alpha_*:​PR65_A*:​_beta_-Catenin*|​S45_emp|​T41_emp|​S37_emp|​S33_emp@Cytoplasm
41. APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PP2A_C*:​PR55_alpha_*:​PR65_A*:​_beta_-Catenin*|​S45_emp|​T41_emp|​S37_emp|​S33_emp@Cytoplasm → PP2A_C*:​PR55_alpha_*:​PR65_A*@Cytoplasm + _beta_-Catenin*@Cytoplasm + AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2@Cytoplasm
42. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho@Cytoplasm → AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho@Cytoplasm
43. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho@Cytoplasm → AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho@Cytoplasm
44. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm + CUL1:​E1*:​FAF*:​NEDD8:​RAD6*:​RBX1:​SKP*:​_beta_TRCP*@Cytoplasm + CK2_alpha_'*:​CK2_alpha_*:​CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​PKD*:​USP15@Cytoplasm → AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​CK2_alpha_'*:​CK2_alpha_*:​CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​CUL1:​E1*:​FAF*:​GSK3*:​NEDD8:​PKD*:​PtdIns(4,5)-P2:​RAD6*:​RBX1:​SKP*:​USP15:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho|​K19_ubi|​K49_ubi:​_beta_TRCP*@Cytoplasm
45. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​CK2_alpha_'*:​CK2_alpha_*:​CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​CUL1:​E1*:​FAF*:​GSK3*:​NEDD8:​PKD*:​PtdIns(4,5)-P2:​RAD6*:​RBX1:​SKP*:​USP15:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho|​K19_ubi|​K49_ubi:​_beta_TRCP*@Cytoplasm → CK2_alpha_'*:​CK2_alpha_*:​CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​CUL1:​NEDD8:​PKD*:​RAD6*:​RBX1:​SKP*:​USP15:​_beta_TRCP*@Cytoplasm + APC|​S1505_pho|​S1501_ubi|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_ubi:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho@Cytoplasm + _beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho|​K19_ubi|​K49_ubi@Cytoplasm
46. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho@Cytoplasm → AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm
47. _beta_-Catenin*@Cytoplasm + JBN*@Cytoplasm → JBN*:​_beta_-Catenin*@Cytoplasm
48. JBN*:​_beta_-Catenin*@Cytoplasm → JBN*:​_beta_-Catenin*@Cilium
49. JBN*:​_beta_-Catenin*@Cilium → su_wca1_s_wca1_s764
50. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm → AMER1*:​APC|​S1505_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm
51. AMER1*:​APC|​S1505_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm → AMER1*:​APC|​S1505_pho|​S1501_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm
52. AMER1*:​APC|​S1505_pho|​S1501_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm → AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm
53. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm → AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm
54. _beta_-Catenin*@Cytoplasm + NKD1@Cytoplasm → NKD1:​_beta_-Catenin*@Cytoplasm
55. Cytoskeleton:​E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho:​ECM or cell-cell contact:​ITGA3:​_alpha_-Catenin*:​_beta_-Catenin*|​pho:​p120*@Cytoplasm + TGFB1:​TGFBR*@Cytoplasm → E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho:​ITGA3:​TGFB1:​TGFBR*:​_beta_-Catenin*|​pho:​p120*@Cytoplasm + ECM or cell-cell contact@default
56. E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho:​ITGA3:​TGFB1:​TGFBR*:​_beta_-Catenin*|​pho:​p120*@Cytoplasm → E-Cadherin*:​ITGA3:​TGFB1:​TGFBR*:​_beta_-Catenin*|​pho:​p120*@Endosome
57. _beta_-Catenin*@Cytoplasm → _beta_-Catenin*|​Y654_pho@Cytoplasm
58. _beta_-Catenin*|​Y654_pho@Cytoplasm → _beta_-Catenin*|​Y654_pho@Nucleus
59. SMAD2|​pho:​_beta_-Catenin*|​Y654_pho@Nucleus → TCF_LEF transcriptional_br_regulation@Nucleus
60. SMAD2|​pho:​_beta_-Catenin*|​Y654_pho@Nucleus → EMT@Nucleus
61. E-Cadherin*:​ITGA3:​TGFB1:​TGFBR*:​_beta_-Catenin*|​pho:​p120*@Endosome → E-Cadherin*:​ITGA3:​TGFB1:​TGFBR*:​_beta_-Catenin*|​Y654_pho|​pho:​p120*@Endosome
62. E-Cadherin*:​ITGA3:​TGFB1:​TGFBR*:​_beta_-Catenin*|​Y654_pho|​pho:​p120*@Endosome → E-Cadherin*:​ITGA3:​TGFB1:​TGFBR*:​p120*@Endosome + _beta_-Catenin*|​Y654_pho@Cytoplasm
63. _beta_-Catenin*|​Y654_pho@Nucleus + SMAD2|​pho@Nucleus → SMAD2|​pho:​_beta_-Catenin*|​Y654_pho@Nucleus
64. ECM or cell-cell contact@default + E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho@Cytoplasm + p120*@Cytoplasm + ITGA3@Cytoplasm + Cytoskeleton@Cytoplasm + _alpha_-Catenin*@Cytoplasm + _beta_-Catenin*|​pho@Cytoplasm → Cytoskeleton:​E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho:​ECM or cell-cell contact:​ITGA3:​_alpha_-Catenin*:​_beta_-Catenin*|​pho:​p120*@Cytoplasm
65. _beta_-Catenin*@Cytoplasm → _beta_-Catenin*|​pho@Cytoplasm
66. _beta_-Catenin*@Cytoplasm → _beta_-Catenin*|​K394_ubi@Cytoplasm
67. _beta_-Catenin*|​K394_ubi@Cytoplasm → WNT canonical pathway@Cytoplasm
68. ITGA9@Cytoplasm + _beta_-Catenin*|​pho@Cytoplasm + E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho@Cytoplasm → E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho:​ITGA9:​_beta_-Catenin*|​pho@Cytoplasm
69. E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho:​ITGA9:​_beta_-Catenin*|​pho@Cytoplasm → E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho:​ITGA9:​_beta_-Catenin*|​Y654_pho|​pho@Cytoplasm
70. E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho:​ITGA9:​_beta_-Catenin*|​Y654_pho|​pho@Cytoplasm → E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho:​ITGA9@Cytoplasm + _beta_-Catenin*|​Y654_pho@Cytoplasm
71. BCL9:​PYGO*:​_beta_-Catenin*|​ace@Nucleus + p300*@Nucleus → BCL9:​PYGO*:​_beta_-Catenin*|​K345_ace|​ace@Nucleus
72. APC:​_beta_-Catenin*@Cytoplasm → Degradation complex WNT canoncical pathway@Cytoplasm
73. APC|​T1487_pho:​CTBP*|​hm2:​HDAC1_2*@Nucleus + BCL9:​DVL*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace@Nucleus → APC|​T1487_pho:​BCL9:​CTBP*|​hm2:​DVL*:​HDAC1_2*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace@Nucleus
74. APC|​T1487_pho:​BCL9:​CTBP*|​hm2:​DVL*:​HDAC1_2*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace@Nucleus → APC|​T1487_pho:​_beta_-Catenin*|​K345_ace|​ace@Nucleus + su_wca1_s_wca3_s405 + CTBP*:​HDAC1_2*:​LEF_TCF*:​WRE*@Nucleus + DVL*:​JUN|​pho|​pho@Nucleus
75. BCL9:​PYGO*:​_beta_-Catenin*|​ace@Nucleus + CBP*|​S92_pho@Nucleus → BCL9:​CBP*|​S92_pho:​PYGO*:​_beta_-Catenin*|​ace|​ace@Nucleus
76. APC|​T1487_pho:​_beta_-Catenin*|​K345_ace|​ace@Nucleus → APC|​T1487_pho:​_beta_-Catenin*|​K345_ace|​ace@Cytoplasm
77. APC|​T1487_pho:​_beta_-Catenin*|​K345_ace|​ace@Cytoplasm → Degradation complex WNT canoncical pathway@Cytoplasm
78. KLF8@Nucleus + BCL9:​PYGO*:​_beta_-Catenin*|​ace@Nucleus + p300*@Nucleus → BCL9:​PYGO*:​_beta_-Catenin*|​K345_ace|​ace@Nucleus
79. BCL9:​PYGO*:​_beta_-Catenin*|​K345_ace|​ace@Nucleus → BCL9:​KLF8|​K67_ace|​K93_ace|​K95_ace:​PYGO*:​_beta_-Catenin*|​K345_ace|​ace@Nucleus
80. HDAC1_2*:​LEF_TCF*:​TLE*|​ubi:​WRE*@Nucleus + BCL9:​CBP*|​S92_pho:​DVL*:​JUN|​pho|​pho:​PYGO*:​_beta_-Catenin*|​ace|​ace@Nucleus → BCL9:​CBP*|​S92_pho:​DVL*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_emp|​ace|​ace@Nucleus + HDAC1_2*:​TLE*|​ubi@Nucleus
81. BCL9:​KLF8|​K67_ace|​K93_ace|​K95_ace:​PYGO*:​_beta_-Catenin*|​K345_ace|​ace@Nucleus + HDAC1_2*:​LEF_TCF*:​TLE*|​ubi:​WRE*@Nucleus → BCL9:​KLF8|​K67_ace|​K93_ace|​K95_ace:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace@Nucleus + HDAC1_2*:​TLE*|​ubi@Nucleus
82. KLF4@Nucleus + BCL9:​PYGO*:​_beta_-Catenin*|​ace@Nucleus + LEF_TCF*@Nucleus + CTBP*@Nucleus + gWRE*@Nucleus → BCL9:​CTBP*:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​ace@Nucleus
83. _beta_-Catenin*@Nucleus + HIPK2@Nucleus + CTBP*@Nucleus + LEF_TCF*@Nucleus → CTBP*:​HIPK2:​LEF_TCF*@Nucleus
84. _beta_-Catenin*@Nucleus → _beta_-Catenin*|​pho|​pho@Nucleus
85. _beta_-Catenin*@Nucleus → _beta_-Catenin*|​ace@Nucleus
86. _beta_-Catenin*|​pho|​pho@Nucleus → degraded
87. BCL9:​PYGO*:​_beta_-Catenin*|​K345_ace|​ace@Nucleus + DVL*:​JUN|​pho|​pho@Nucleus → BCL9:​DVL*:​JUN|​pho|​pho:​PYGO*:​_beta_-Catenin*|​K345_ace|​ace@Nucleus
88. DVL*:​JUN|​pho|​pho@Nucleus + BCL9:​CBP*|​S92_pho:​PYGO*:​_beta_-Catenin*|​ace|​ace@Nucleus → BCL9:​CBP*|​S92_pho:​DVL*:​JUN|​pho|​pho:​PYGO*:​_beta_-Catenin*|​ace|​ace@Nucleus
89. _beta_-Catenin*@Cytoplasm → _beta_-Catenin*@Nucleus
90. BCL9@Nucleus + _beta_-Catenin*|​ace@Nucleus + PYGO*@Nucleus → BCL9:​PYGO*:​_beta_-Catenin*|​ace@Nucleus
91. HDAC1_2*:​LEF_TCF*:​TLE*|​ubi:​WRE*@Nucleus + BCL9:​DVL*:​JUN|​pho|​pho:​PYGO*:​_beta_-Catenin*|​K345_ace|​ace@Nucleus → BCL9:​DVL*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace@Nucleus + HDAC1_2*:​TLE*|​ubi@Nucleus
92. BCL9:​PYGO*:​_beta_-Catenin*|​K345_ace|​ace@Nucleus + SMAD1|​pho@Nucleus → BCL9:​PYGO*:​SMAD1|​pho:​TCF4:​_beta_-Catenin*|​K345_ace|​ace@Nucleus
93. _beta_-Catenin*@Nucleus + NICD*@Nucleus → su_wca1_s_wca3_s263
94. _beta_-Catenin*@Nucleus + NFKB1_p50*:​RELA@Nucleus → su_wca1_s_wca3_s281
95. Sonic hedgehog pathway@Extracellular space → _beta_-Catenin*@Cytoplasm
96. su_wca1_s_wca3_s314 → APC|​S2034_pho:​_beta_-Catenin*@Cytoplasm
97. su_wca1_s_wca3_s317 → APC:​_beta_-Catenin*@Cytoplasm
98. _beta_-Catenin*@Nucleus + APC|​S2034_pho@Nucleus → su_wca1_s_wca3_s314
99. _beta_-Catenin*@Nucleus + APC@Nucleus → su_wca1_s_wca3_s317
100. APC|​S2034_pho:​_beta_-Catenin*@Cytoplasm → Degradation complex WNT canoncical pathway@Cytoplasm
101. _beta_-Catenin*@Cytoplasm + Kindlin2*@Cytoplasm → Kindlin2*:​_beta_-Catenin*@Cytoplasm
102. Kindlin2*:​_beta_-Catenin*@Cytoplasm → su_wca1_s_wca4_s8
103. _beta_-Catenin*|​S522_pho@Cytoplasm → _beta_-Catenin*|​S522_pho|​S675_pho@Cytoplasm
104. _beta_-Catenin*@Cytoplasm → _beta_-Catenin*|​S522_pho@Cytoplasm
105. _beta_-Catenin*|​S522_pho|​S675_pho@Cytoplasm → _beta_-Catenin*|​S522_pho|​S675_pho@Nucleus
106. _beta_-Catenin*|​S522_pho|​S675_pho@Nucleus → Transcription@Nucleus
107. _beta_-Catenin*@Cytoplasm → _beta_-Catenin*|​S552_pho@Cytoplasm
108. _beta_-Catenin*|​S552_pho@Cytoplasm → _beta_-Catenin*|​S552_pho|​pho@Cytoplasm
109. r_beta_-Catenin*@Nucleus → _beta_-Catenin*@Cytoplasm
110. E-Cadherin*@Cytoplasm + p120*@Cytoplasm + _alpha_-Catenin*@Cytoplasm + _beta_-Catenin*@Cytoplasm + Cytoskeleton@Cytoplasm → Cytoskeleton:​E-Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*:​p120*@Cytoplasm
111. _beta_-Catenin*@Cytoplasm → WNT canonical pathway@Cytoplasm
112. Cytoskeleton:​E-Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*:​p120*@Cytoplasm → _beta_-Catenin*@Cytoplasm + p120*@Cytoplasm + E-Cadherin*@Cytoplasm + _alpha_-Catenin*@Cytoplasm
113. Cytoskeleton:​E-Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*:​p120*@Cytoplasm → Cytoskeleton:​E-Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*|​Y142_pho:​p120*@Cytoplasm
114. Cytoskeleton:​E-Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*|​Y142_pho:​p120*@Cytoplasm → _beta_-Catenin*|​Y142_pho@Cytoplasm + E-Cadherin*:​_alpha_-Catenin*:​cytoskeleton:​p120*@Cytoplasm
115. _beta_-Catenin*|​Y142_pho@Cytoplasm → WNT canonical pathway nucleus@Cytoplasm

1. gMYC@Nucleus → rMYC@Nucleus
2. gMIR183@Nucleus → arMIR183@Nucleus
3. gID2@Nucleus → rID2@Nucleus
4. gAXIN2@Nucleus → rAXIN2@Nucleus
5. gSNAI2@Nucleus → rSNAI2@Nucleus
6. gCyclinD1*@Nucleus → rCyclinD1*@Nucleus
7. gClaudin1*@Nucleus → rClaudin1*@Nucleus
8. gClaudin2*@Nucleus → rClaudin2*@Nucleus
9. gMMP14@Nucleus → rMMP14@Nucleus
10. gFibronectin*@Nucleus → rFibronectin*@Nucleus
11. gmiR96@Nucleus → armiR96@Nucleus
12. gmiR182@Nucleus → armiR182@Nucleus
13. DEPTOR:​MLST8:​MTOR:​PRAS40*:​RPTOR@INNATE_IMMUNE_CELL_Cytosol → (DEPTOR:​MLST8:​MTOR|​pho:​PRAS40*:​RPTOR)|​active@INNATE_IMMUNE_CELL_Cytosol
14. gCCR7@INNATE_IMMUNE_CELL_Cytosol → rCCR7@INNATE_IMMUNE_CELL_Cytosol
15. SRC@Cytoplasm → SRC@Cytoplasm
16. gCyclinD*@Nucleus → rCyclinD*@Nucleus
17. gAXIN1@Nucleus → rAXIN1@Nucleus
18. gMMP9@Nucleus → rMMP9@Nucleus
19. gGenes under control of _br_CBP-mediated transcription*@Nucleus → rRNA@Nucleus
20. gTCF4@Nucleus → rTCF4@Nucleus
21. gRAD6B*@Nucleus → rRAD6B*@Nucleus
22. gBCL9@Nucleus → rBCL9@Nucleus
23. gMIR372@Nucleus → arMIR372@Nucleus
24. gMIR373@Nucleus → arMIR373@Nucleus
25. gIRS2@Nucleus → rIRS2@Nucleus
26. gCRIPTO-1*@Nucleus → rCRIPTO-1*@Nucleus
27. gMYC@Nucleus → rMYC@Nucleus
28. gGene under control of_br_ P300-mediated transcription*@Nucleus → rRNA@Nucleus