Gene MMP14 map

Identifiers
HUGO:MMP14
matrix metallopeptidase 14 (membrane-inserted)
HUGO:MMP14, HGNC:7160, ENTREZ:4323, GENECARDS:GC14P023305??

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / MATRIX_REGULATION  map
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map

References
CASCADE:TNF
CASCADE:INTEGRIN
PMID:11112697
TNF-?? upregulates MT1-MMP (MMP14) mRNA in organ-cultured human skin and dermal fibroblasts in a collagen environment
NF-??B inhibitor, SN50, blocks TNF-?? and collagen mediated MT1-MMP expression and pro-MMP-2 activation.
PMID:17420280
Analysis of matrix metalloproteinase in vitro and in vivo revealed disturbed MMP13 and MMP14 synthesis in alpha11(-/-) cells.

Modifications:
In compartment: Cytosol
  1. gMMP14@Cytosol map
In compartment: Nucleus
  1. gMMP14@Nucleus map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gMMP14@Cytosol map → map rMMP14@Cytosol map
    2. gMMP14@Nucleus map → map rMMP14@Nucleus map
    3. gMMP14@Nucleus map → map rMMP14@Nucleus map
    As Catalyser: