Protein SMAD1 map

Identifiers
SMAD family member 1
"MAD, mothers against decapentaplegic homolog 1 (Drosophila)", MADH1, "SMAD, mothers against DPP homolog 1 (Drosophila)"
HUGO:SMAD1 HGNC:6767 ENTREZ:4086 UNIPROT:Q15797
HUGO:SMAD1 HGNC:6767 ENTREZ:4086 UNIPROT:Q15797 GENECARDS:SMAD1 REACTOME:64616 KEGG:4086 ATLASONC:GC_SMAD1 WIKI:SMAD1

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / WNT_CANONICAL  map

SMAD1|​pho@Nucleus

References
s_wca3_re64( Survival  map ):
Under pathological conditions this complex will be formed. This complex has synergistic positive effect on myc gene expression.
PMID:15576399
s_wca3_re65( Survival  map ):
PMID:22761862
Smad1 alone inhibits myc expression while b-catenin/TCF4 activates gene expression. Highest gene expression obtained when SMAD1/b-catenin/TCF4 complex is formed
Mi-2/NuRD
PMID:22290435
su_wca1_s_wca3_re65( Survival  map ):

Modifications:
In compartment: Cytosol
  1. SMAD1@Cytosol map
In compartment: Nucleus
  1. SMAD1|​pho@Nucleus map
Participates in complexes:
In compartment: Nucleus
  1. BCL9:​PYGO*:​SMAD1|​pho:​TCF4:​_beta_-Catenin*|​K345_ace|​ace@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. rSMAD1@Nucleus map → map SMAD1@Cytosol map
  2. BCL9:​PYGO*:​_beta_-Catenin*|​K345_ace|​ace@Nucleus map + SMAD1|​pho@Nucleus map → map BCL9:​PYGO*:​SMAD1|​pho:​TCF4:​_beta_-Catenin*|​K345_ace|​ace@Nucleus map
  3. TGF-_beta_ pathway@Nucleus map → map SMAD1|​pho@Nucleus map
As Catalyser:
  1. gMYC@Nucleus map → map rMYC@Nucleus map