SRC

Protein SRC

Identifiers
HUGO:SRC
SRC proto-oncogene, non-receptor tyrosine kinase
HUGO:SRC hgnc_id:HGNC:11283 HGNC:11283 ENTREZ:6714 UNIPROT:P12931
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
SRC1 "v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog"
HUGO:SRC HGNC:11283 ENTREZ:6714 UNIPROT:P12931
HUGO:SRC HGNC:11283 ENTREZ:6714 UNIPROT:P12931 GENECARDS:SRC REACTOME:402877 KEGG:6714 ATLASONC:SRCID448ch20q11 WIKI:SRC

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / ACTIVATING_CHECKPOINTS
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / MAPK
Survival / WNT_CANONICAL

References
PMID:26552706
CASCADE:INTEGRIN
CASCADE:CAV
PMID:11476890
Src kinases participate in PTK2 (FAK) phosphorylation downstream of integrin signaling
Src???/??? fibroblasts are slightly defective and fibroblasts deficient for the src, fyn and yes genes exhibit a dramatic defect in the cell adhesion-dependent tyrosine phosphorylation of FAK.
hese observations suggest that cell adhesion-dependent tyrosine phosphorylation of FAK occurs in two phases. The first, autophosphorylation phase, occurs in the absence of Src and results in the tyrosine phosphorylation of FAK residue 397. The second phase occurs following recruitment of Src into complex with FAK and results in phosphorylation of FAK at other tyrosine residues leading to the full activation of FAK and transmission of downstream signals.
PMID:16919435
Integrin-stimulated FAK phosphorylation at Y397 creates a high-affinity binding site for the Src-homology 2 (SH2) domain of SFKs. The binding of Src to FAK can lead to the conformational activation of SFKs and the formation of a transient FAK???Src signaling complex in fibroblasts and epithelial cells
PMID:25572304
FAK undergoes autophosphorylation that leads to its association with Src, resulting in activation of both kinases.
PMID:27216177
FAP as a persistent activator of fibroblastic STAT3 through a uPAR-dependent FAK-Src-JAK2 signaling pathway.
PMID:17517963
Src is involved in activation of Rac (Servitja et al., 2003; Kawakatsu et al., 2005) and Cdc42 (Miyamoto et al., 2003; Tu et al., 2003; Fukuyama et al., 2005) and can inhibit Rho through activation of p190RhoGAP
caveolin-1 stimulates normal Rho GTP loading through inactivation of the Src???p190RhoGAP pathway.
Many activated RTKs induce the Src-dependent activation of PLCG
PMID:17496910

SRC|pho|active@Cytosol

References
ca_re463( Cancer Associated Fibroblasts ):
PMID:??12094222??
VAV proteins activate RAC1 via induction of GDP/GTP exchange.

SRC@Cytoplasm

References
su_mpk1_mpk1_re40( Survival ):
In addition to Grb2/SOS PLCG and SRC are also recruited to activated PTKRs at the PM.
Activation of the TCR results in tyrosine phosphorylation of the ?? chain of the receptor by Src family kinases and the resulting phosphotyrosines serve to recruit ZAP-70 (not modelled) that in turn phosphorylates the scaffold protein LAT (not modelled) at multiple sites.
Recruitment to the membrane and tyrosine phosphorylation enhance the enzymatic activity of PLC-g leading to the formation of two second messengers diacylglycerol (DAG) and inositol 145-trisphosphate (IP3). IP3 releases Ca2+ from internal stores which in turn acts in concert with DAG to translocate protein kinase C (PKC) to the cell membrane and stimulate its enzymatic activity.
PMID:19615955 PMID:16488589 PMID:15567848
su_wca1_s_wca2_re39( Survival ):
Integrin alphaIII beta1 can activate Src
PMID:22203675
Other integrin family member activates as well Src
PMID:19734908

SRC@Cytoplasm

Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / WNT_CANONICAL

References
s_wca2_re39( Survival ):
Integrin alphaIII beta1 can activate Src
PMID:22203675
Other integrin family member activates as well Src
PMID:19734908
s_wca2_re45( Survival ):
Src phosphorylates Y654 residue on b-catenin
PMID:16099633
s_wca2_re68:( Survival ) PMID:22370635

Modifications:
In compartment: Cytoplasm

SRC@Cytoplasm
SRC@Cytoplasm

In compartment: Cytosol

SRC@Cytosol
SRC|pho|active@Cytosol

In compartment: T_cell

SRC@T_cell

Participates in complexes:
In compartment: Plasma Membrane

Participates in reactions:
As Reactant or Product:

As Catalyser: