Complex BCL9:PYGO*:SMAD1:TCF4:_beta_-Catenin* map
Complex composition:

  1. BCL9 map
  2. PYGO* map
  3. _beta_-Catenin* map
  4. TCF4 map
  5. SMAD1 map

BCL9:​PYGO*:​SMAD1|​pho:​TCF4:​_beta_-Catenin*|​K345_ace|​ace@Nucleus

Identifiers
NAME:BCL9:PYGO*:SMAD1:TCF4:_beta_-Catenin*

References
NOTE: In the original article (PMID:15576399)is unknown if p300/PYGO/bcl9 and wich PTMs on b-catenin are present in this complex. Based on canonical transcription by b-catenin the afore mentioned proteins are required for activating gene transcription.
s_wca3_re64( Survival  map ):
Under pathological conditions this complex will be formed. This complex has synergistic positive effect on myc gene expression.
PMID:15576399
s_wca3_re65( Survival  map ):
PMID:22761862
Smad1 alone inhibits myc expression while b-catenin/TCF4 activates gene expression. Highest gene expression obtained when SMAD1/b-catenin/TCF4 complex is formed
Mi-2/NuRD
PMID:22290435
su_wca1_s_wca3_re65( Survival  map ):

Modifications:
Participates in complexes:
In compartment: Nucleus
  1. BCL9:​PYGO*:​SMAD1|​pho:​TCF4:​_beta_-Catenin*|​K345_ace|​ace@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. BCL9:​PYGO*:​_beta_-Catenin*|​K345_ace|​ace@Nucleus map + SMAD1|​pho@Nucleus map → map BCL9:​PYGO*:​SMAD1|​pho:​TCF4:​_beta_-Catenin*|​K345_ace|​ace@Nucleus map
As Catalyser:
  1. gMYC@Nucleus map → map rMYC@Nucleus map