Identifiers
catenin (cadherin-associated protein), alpha 1, 102kDa
HUGO:CTNNA1 HGNC:2509 ENTREZ:1495 UNIPROT:P35221
HUGO:CTNNA1 HUGO:CTNNA2 HUGO:CTNNA3
HUGO:CTNNA1 HGNC:2509 ENTREZ:1495 UNIPROT:P35221 GENECARDS:CTNNA1 REACTOME:53044 KEGG:1495 ATLASONC:GC_CTNNA1 WIKI:CTNNA1
catenin (cadherin-associated protein) alpha 2
HUGO:CTNNA2 HGNC:2510 ENTREZ:1496 UNIPROT:P26232 GENECARDS:CTNNA2 REACTOME:53046 KEGG:1496 WIKI:CTNNA2
catenin (cadherin-associated protein) alpha 3
HUGO:CTNNA3 HGNC:2511 ENTREZ:29119 UNIPROT:Q9UI47 GENECARDS:CTNNA3 KEGG:29119 ATLASONC:GC_CTNNA3 WIKI:CTNNA3
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / CELL_CELL_ADHESIONS
EMT Senescence / ADHERENS_JUNCTIONS
EMT Senescence / LYSOSOME_ENDOSOME
HMC:TUMOR_PROMOTING_INFLAMMATION
Innate Immunity / IMMUNOSUPPPRESSIVE_CORE_PATHWAYS
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / WNT_CANONICAL
Survival / WNT_NON_CANONICAL
References
PMID:16325583
Monomeric CTNNA1 binds more strongly to E-cadherin/CTNNB1, whereas the dimer preferentially binds actin filaments
DENDRITIC_CELL
CASCADE:CATENINB
PMID:17936032
Disruption of E-cadherin-mediated contacts induce DC maturation.
It activates a ??-catenin-TCF/LEF signaling pathway independent of TLR signaling
References
em_emtc_emtc_re1022( EMT Senescence ):
PMID:15609097
CTNNB1 (beta-catenin) binds with high affinity to the distal Cadherin cytoplasmic tail.
Cadherin recruits CTNNA1 (alpha-catenin) to the complex.
CTNNA1 (alpha-catenin) binds to Actin filaments directly
CTNNA1 (alpha-catenin) and can also associate with other actin-binding proteins (MLLT4 or Formin)
CTNND1 (delta-catenin or p120) binds directly to Cadherin independently of the other catenins.
Catenins/Cadherin complex can further interact with a range of singaling molecules which participate in either cellular signaling or control of cytoskeletal dynamics.
Stability of Cadherin/Catenins complex and thereby the integrity of adherens junctions is controlled by phosphorylation/dephosphorylation.
em_emtc_emtc_re1023( EMT Senescence ):
PMID:16325583
Monomeric CTNNA1 binds more strongly to E-cadherin/CTNNB1, whereas the dimer preferentially binds actin filaments
References
em_emtc_emtc_re1023( EMT Senescence ):
PMID:16325583
Monomeric CTNNA1 binds more strongly to E-cadherin/CTNNB1, whereas the dimer preferentially binds actin filaments
References
em_re1453( EMT Senescence ):
PMID??:10402472
We conclude that a pool of surface E-cadherin is constantly trafficked through an endocytic, recycling pathway and that this may provide a mechanism for regulating the availability of E-cadherin for junction formation in development, tissue remodeling, and tumorigenesis.
References
su_wnc1_s_wnc4_re31( Survival ):
binding of G-alpha12 toE-cadherin results of loss of binding of b-catenin from the adherence junction
PMID:11136230
su_wnc1_s_wnc4_re24( Survival ):
Complex of G-alpha12 and p120 stabilises binding of E-cadherin in Adhesion-complex. G-alpha12 is found back in complex with p120 and E-cadherin
PMID:15240885
su_wca1_s_wca2_re50:( Survival ) PMID:22659456 PMID:22007144 PMID:19171760 PMID:10931041
Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / WNT_CANONICAL
References
s_wnc4_re31( Survival ):
binding of G-alpha12 toE-cadherin results of loss of binding of b-catenin from the adherence junction
PMID:11136230
s_wca2_re50:( Survival ) PMID:22659456 PMID:22007144 PMID:19171760 PMID:10931041
s_wnc4_re24( Survival ):
Complex of G-alpha12 and p120 stabilises binding of E-cadherin in Adhesion-complex. G-alpha12 is found back in complex with p120 and E-cadherin
PMID:15240885
→ _alpha_-Catenin*@Cytosol
+ Cadherin*@Cytosol + _alpha_-Catenin*@Cytosol → Cadherin*:_alpha_-Catenin*:_beta_-Catenin*@Cytosol
→ _alpha_-Catenin*|hm2@Cytosol
+ _alpha_-Catenin*|hm2@Cytosol → em_emtc_emtc_s3669
→ _alpha_-Catenin*@Cytosol
+ Cadherin*:p120*@Cytosol + Actin cytoskeletal*@Cytosol → Cadherin*:_alpha_-Catenin*:_beta_-Catenin*:p120*@Cytosol
→ E-Cadherin*|Y_pho@Cytosol
→ Adherens junctions@Cytosol
→ _alpha_-Catenin*@Clathrin coated vesicle
→ E-Cadherin*@Clathrin coated vesicle
→ _beta_-Catenin*@Clathrin coated vesicle
→ p120*@Clathrin coated vesicle
→ _alpha_-Catenin*@Endosome
→ _alpha_-Catenin*@Lysosome
→ degraded
→ E-Cadherin*@Caveolin vesicle
→ E-Cadherin*@Macropinosome
→ degraded
→ _beta_-Catenin*@INNATE_IMMUNE_CELL_Cytosol + E-Cadherin*@INNATE_IMMUNE_CELL_Cytosol + _alpha_-Catenin*@INNATE_IMMUNE_CELL_Cytosol
+ TGFB1:TGFBR*@Cytoplasm → E-Cadherin*|S840_pho|S853_pho|S855_pho|S849_pho:ITGA3:TGFB1:TGFBR*:_beta_-Catenin*|pho:p120*@Cytoplasm + ECM or cell-cell contact@default
+ E-Cadherin*|S840_pho|S853_pho|S855_pho|S849_pho@Cytoplasm + p120*@Cytoplasm + ITGA3@Cytoplasm + Cytoskeleton@Cytoplasm + _alpha_-Catenin*@Cytoplasm + _beta_-Catenin*|pho@Cytoplasm → Cytoskeleton:E-Cadherin*|S840_pho|S853_pho|S855_pho|S849_pho:ECM or cell-cell contact:ITGA3:_alpha_-Catenin*:_beta_-Catenin*|pho:p120*@Cytoplasm
+ p120*@Cytoplasm + _alpha_-Catenin*@Cytoplasm + _beta_-Catenin*@Cytoplasm + Cytoskeleton@Cytoplasm → Cytoskeleton:E-Cadherin*:_alpha_-Catenin*:_beta_-Catenin*:p120*@Cytoplasm
→ _beta_-Catenin*@Cytoplasm + p120*@Cytoplasm + E-Cadherin*@Cytoplasm + _alpha_-Catenin*@Cytoplasm
→ Cytoskeleton:E-Cadherin*:_alpha_-Catenin*:_beta_-Catenin*|Y142_pho:p120*@Cytoplasm
→ _beta_-Catenin*|Y142_pho@Cytoplasm + E-Cadherin*:_alpha_-Catenin*:cytoskeleton:p120*@Cytoplasm