Protein E-Cadherin* map

Identifiers
cadherin 1, type 1, E-cadherin (epithelial)
HUGO:CDH1, HGNC:1748, ENTREZ:999, GENECARDS:GC16P068771, UNIPROT:P12830
HUGO:CDH1, HGNC:1748, ENTREZ:999, UNIPROT:P12830
HUGO:CDH1
HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1
UVO

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CELL_CELL_ADHESIONS  map
 EMT Senescence  map  / ADHERENS_JUNCTIONS  map
 EMT Senescence  map  / LYSOSOME_ENDOSOME  map
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
 Cell Cycle DNA Repair  map  / M_CC_PHASE  map
HMC:TUMOR_PROMOTING_INFLAMMATION
 Innate Immunity  map  / IMMUNOSUPPPRESSIVE_CORE_PATHWAYS  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / WNT_CANONICAL  map
 Survival  map  / WNT_NON_CANONICAL  map

References
PMID:10671552
PMID:11348595
PMID:17928543
in vitro phosphorylation of Cadherin at S834, 836, 842 significantly enhances the affinity with which beta-catenin binds cadherins.
GSK3B and CSNK2 (casein kinase II) have been shown to phosphorylate these sites in vitro.
PMID:16371504
N-cadherin is phosphorylated by c-Src at Tyr-820, Tyr-853, Tyr-860, Tyr-884, and Tyr-886.
Phosphorylation of Tyr-860 (Tyr-835 in E-cadherin) can disrupt cadherin binding to beta-catenin
The endocytosis of trans-interacting E-cadherin was inhibited by Rac and Cdc42 small G proteins, which were activated by trans-interacting E-cadherin.
PMID:22674073
Studies have suggested that cadherin endocytosis may occur through both caveolin-mediated and macropinocytosis-like pathways. Akhtar and colleagues found that a dominant-active form of the small GTPase Rac1 could disrupt cell-cell adhesion in keratinocytes. This was associated with the endocytosis of E-cadherin through a pathway that appeared to be distinct from the uptake of transferrin, which is clathrin-mediated, and through structures that co-localized with caveolin
Akhtar and colleagues found that a dominant-active form of the small GTPase Rac1 could disrupt cell-cell adhesion in keratinocytes. This was associated with the endocytosis of E-cadherin through a pathway that appeared to be distinct from the uptake of transferrin, which is clathrin-mediated, and through structures that co-localized with caveolin
In contrast, Bryant and colleagues characterized the EGF-induced internalization of E-cadherin in a breast carcinoma cell line, in which E-cadherin was internalized along with the cadherin-binding proteins p120 and ??-catenin, as Rac1-modulated macropinocytosis
PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786
 DENDRITIC_CELL  map
CASCADE:CATENINB
PMID:17936032, PMID:22174153
Disruption of E-cadherin-mediated contacts induce DC maturation.
It activates a ??-catenin-TCF/LEF signaling pathway independent of TLR signaling
PMID:19029934
PMID:22007144

E-Cadherin*@Cytosol

References
em_emtc_emtc_re1007( EMT Senescence  map ):
PMID:10671552
PMID:11348595
PMID:17928543
in vitro phosphorylation of Cadherin at S834, 836, 842 significantly enhances the affinity with which beta-catenin binds cadherins.
GSK3B and CSNK2 (casein kinase II) have been shown to phosphorylate these sites in vitro.
em_emtc_emtc_re1008( EMT Senescence  map ):
PMID:17353278
Phosphorylation of E-cadherin at S846 by casein kinase I decreases its ability to bind to CTNNB1.

E-Cadherin*|​hm2@Cytosol

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map
 EMT Senescence  map  / CELL_CELL_ADHESIONS  map
 EMT Senescence  map  / ADHERENS_JUNCTIONS  map

References
PMID:11413131
E-cadherin dimerization is essential for adhesion to the integrin aEb7
PMID:17325197
Interaction between E-cadherin and aEb7 integrin plays major role in effective tumor cell lysis, during cytolytic granule polarization and subsequent exocytosis
em_emtc_emtc_re756( EMT Senescence  map ):
PMID:16371504
The endocytosis of trans-interacting E-cadherin was inhibited by Rac and Cdc42 small G proteins, which were activated by trans-interacting E-cadherin.

E-Cadherin*|​S_pho@Cytosol

References
em_emtc_emtc_re1007( EMT Senescence  map ):
PMID:10671552
PMID:11348595
PMID:17928543
in vitro phosphorylation of Cadherin at S834, 836, 842 significantly enhances the affinity with which beta-catenin binds cadherins.
GSK3B and CSNK2 (casein kinase II) have been shown to phosphorylate these sites in vitro.
em_emtc_emtc_re1008( EMT Senescence  map ):
PMID:17353278
Phosphorylation of E-cadherin at S846 by casein kinase I decreases its ability to bind to CTNNB1.

E-Cadherin*|​hm2@Neighbouring Cell

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map
 EMT Senescence  map  / CELL_CELL_ADHESIONS  map
 EMT Senescence  map  / ADHERENS_JUNCTIONS  map

References
PMID:11413131
E-cadherin dimerization is essential for adhesion to the integrin aEb7
PMID:17325197
Interaction between E-cadherin and aEb7 integrin plays major role in effective tumor cell lysis, during cytolytic granule polarization and subsequent exocytosis

E-Cadherin*|​Y_pho@Clathrin coated vesicle

References
em_re1458( EMT Senescence  map ):
PMID:22674073
Cadherin internalization can occur through either clathrin-mediated, caveolin-mediated, or macropinocytosis-like pathways. Internalized cadherin is then sorted either for lysosomal degradation or recycling back to the plasma membrane.

E-Cadherin*@Clathrin coated vesicle

References
em_re1454( EMT Senescence  map ):
PMID??:10402472
We conclude that a pool of surface E-cadherin is constantly trafficked through an endocytic, recycling pathway and that this may provide a mechanism for regulating the availability of E-cadherin for junction formation in development, tissue remodeling, and tumorigenesis.
PMID:22674073
Clathrin-mediated endocytosis appears to be responsible for two types of growth factor-induced cadherin internalization, FGF-mediated internalization of E-cadherin () and VEGF-mediated internalization of VE-cadherin.

E-Cadherin*|​Y_pho@Endosome

References
em_re1488( EMT Senescence  map ):
PMID:22674073
Cadherin internalization can occur through either clathrin-mediated, caveolin-mediated, or macropinocytosis-like pathways. Internalized cadherin is then sorted either for lysosomal degradation or recycling back to the plasma membrane.

E-Cadherin*|​Y_pho@Cytosol

References
em_emtc_emtc_re1632( EMT Senescence  map ):
PMID:16371504
N-cadherin is phosphorylated by c-Src at Tyr-820, Tyr-853, Tyr-860, Tyr-884, and Tyr-886.
Phosphorylation of Tyr-860 (Tyr-835 in E-cadherin) can disrupt cadherin binding to beta-catenin
PMID??:10402472
We conclude that a pool of surface E-cadherin is constantly trafficked through an endocytic, recycling pathway and that this may provide a mechanism for regulating the availability of E-cadherin for junction formation in development, tissue remodeling, and tumorigenesis.
em_re1458( EMT Senescence  map ):
PMID:22674073
Cadherin internalization can occur through either clathrin-mediated, caveolin-mediated, or macropinocytosis-like pathways. Internalized cadherin is then sorted either for lysosomal degradation or recycling back to the plasma membrane.
em_re1482( EMT Senescence  map ):
Studies have suggested that cadherin endocytosis may occur through both caveolin-mediated and macropinocytosis-like pathways. Akhtar and colleagues found that a dominant-active form of the small GTPase Rac1 could disrupt cell-cell adhesion in keratinocytes. This was associated with the endocytosis of E-cadherin through a pathway that appeared to be distinct from the uptake of transferrin, which is clathrin-mediated, and through structures that co-localized with caveolin
Akhtar and colleagues found that a dominant-active form of the small GTPase Rac1 could disrupt cell-cell adhesion in keratinocytes. This was associated with the endocytosis of E-cadherin through a pathway that appeared to be distinct from the uptake of transferrin, which is clathrin-mediated, and through structures that co-localized with caveolin
In contrast, Bryant and colleagues characterized the EGF-induced internalization of E-cadherin in a breast carcinoma cell line, in which E-cadherin was internalized along with the cadherin-binding proteins p120 and ??-catenin, as Rac1-modulated macropinocytosis

E-Cadherin*@Endosome

References
em_re1486( EMT Senescence  map ):
PMID:22674073
Cadherin internalization can occur through either clathrin-mediated, caveolin-mediated, or macropinocytosis-like pathways. Internalized cadherin is then sorted either for lysosomal degradation or recycling back to the plasma membrane.
em_re1465( EMT Senescence  map ):
PMID:11294891
Rac1 Regulates Adherens Junctions through Endocytosis of E-Cadherin.
Rac1 has an ambivalent role on adherens junction. It favourise them in some case because it favours E-cadherin endocytose, however it does promote an endocytose towards degradation rather than recycling.
Rac1 thus favours the lowering of AJ, even if it does not favourise their complete depletion. The adjustment variable being the amout of Trans-activated E-cahderin
em_re1497( EMT Senescence  map ):
E-cadherin does not travel directly from the Golgi complex to the cell surface, but transits first through Rab11-positive recycling endosomes. Rab11 is involved in E-cadherin localization to the surface of the cell .
In addition to acting as way stations for newly synthesized cadherin on its way to the plasma membrane, Rab11-positive recycling endosomes can also sort internalized cadherin for recycling back to the cell surface.
Desclozeaux and colleagues also found that cadherin recycling is necessary for maintaining adherens junctions.

E-Cadherin*@Lysosome

References
em_re1465( EMT Senescence  map ):
PMID:11294891
PMID:22674073
Rac1 Regulates Adherens Junctions through Endocytosis of E-Cadherin.
Rac1 has an ambivalent role on adherens junction. It favourise them in some case because it favours E-cadherin endocytose, however it does promote an endocytose towards degradation rather than recycling.
Rac1 thus favours the lowering of AJ, even if it does not favourise their complete depletion. The adjustment variable being the amout of Trans-activated E-cahderin

E-Cadherin*|​Y_pho@Macropinosome

References
em_re1483( EMT Senescence  map ):
PMID:22674073
Studies have suggested that cadherin endocytosis may occur through both caveolin-mediated and macropinocytosis-like pathways. Akhtar and colleagues found that a dominant-active form of the small GTPase Rac1 could disrupt cell-cell adhesion in keratinocytes. This was associated with the endocytosis of E-cadherin through a pathway that appeared to be distinct from the uptake of transferrin, which is clathrin-mediated, and through structures that co-localized with caveolin
Akhtar and colleagues found that a dominant-active form of the small GTPase Rac1 could disrupt cell-cell adhesion in keratinocytes. This was associated with the endocytosis of E-cadherin through a pathway that appeared to be distinct from the uptake of transferrin, which is clathrin-mediated, and through structures that co-localized with caveolin
In contrast, Bryant and colleagues characterized the EGF-induced internalization of E-cadherin in a breast carcinoma cell line, in which E-cadherin was internalized along with the cadherin-binding proteins p120 and ??-catenin, as Rac1-modulated macropinocytosis
em_re1489( EMT Senescence  map ):
Cadherin internalization can occur through either clathrin-mediated, caveolin-mediated, or macropinocytosis-like pathways. Internalized cadherin is then sorted either for lysosomal degradation or recycling back to the plasma membrane.

E-Cadherin*|​Y_pho@Caveolin vesicle

References
em_re1482( EMT Senescence  map ):
PMID:22674073
Studies have suggested that cadherin endocytosis may occur through both caveolin-mediated and macropinocytosis-like pathways. Akhtar and colleagues found that a dominant-active form of the small GTPase Rac1 could disrupt cell-cell adhesion in keratinocytes. This was associated with the endocytosis of E-cadherin through a pathway that appeared to be distinct from the uptake of transferrin, which is clathrin-mediated, and through structures that co-localized with caveolin
Akhtar and colleagues found that a dominant-active form of the small GTPase Rac1 could disrupt cell-cell adhesion in keratinocytes. This was associated with the endocytosis of E-cadherin through a pathway that appeared to be distinct from the uptake of transferrin, which is clathrin-mediated, and through structures that co-localized with caveolin
In contrast, Bryant and colleagues characterized the EGF-induced internalization of E-cadherin in a breast carcinoma cell line, in which E-cadherin was internalized along with the cadherin-binding proteins p120 and ??-catenin, as Rac1-modulated macropinocytosis
em_re1488( EMT Senescence  map ):
Cadherin internalization can occur through either clathrin-mediated, caveolin-mediated, or macropinocytosis-like pathways. Internalized cadherin is then sorted either for lysosomal degradation or recycling back to the plasma membrane.

E-Cadherin*@Macropinosome

References
em_re1485( EMT Senescence  map ):
PMID:22674073
Studies have suggested that cadherin endocytosis may occur through both caveolin-mediated and macropinocytosis-like pathways. Akhtar and colleagues found that a dominant-active form of the small GTPase Rac1 could disrupt cell-cell adhesion in keratinocytes. This was associated with the endocytosis of E-cadherin through a pathway that appeared to be distinct from the uptake of transferrin, which is clathrin-mediated, and through structures that co-localized with caveolin
Akhtar and colleagues found that a dominant-active form of the small GTPase Rac1 could disrupt cell-cell adhesion in keratinocytes. This was associated with the endocytosis of E-cadherin through a pathway that appeared to be distinct from the uptake of transferrin, which is clathrin-mediated, and through structures that co-localized with caveolin
In contrast, Bryant and colleagues characterized the EGF-induced internalization of E-cadherin in a breast carcinoma cell line, in which E-cadherin was internalized along with the cadherin-binding proteins p120 and ??-catenin, as Rac1-modulated macropinocytosis
em_re1487( EMT Senescence  map ):
Cadherin internalization can occur through either clathrin-mediated, caveolin-mediated, or macropinocytosis-like pathways. Internalized cadherin is then sorted either for lysosomal degradation or recycling back to the plasma membrane.

E-Cadherin*@Caveolin vesicle

References
em_re1484( EMT Senescence  map ):
PMID:22674073
Studies have suggested that cadherin endocytosis may occur through both caveolin-mediated and macropinocytosis-like pathways. Akhtar and colleagues found that a dominant-active form of the small GTPase Rac1 could disrupt cell-cell adhesion in keratinocytes. This was associated with the endocytosis of E-cadherin through a pathway that appeared to be distinct from the uptake of transferrin, which is clathrin-mediated, and through structures that co-localized with caveolin
Akhtar and colleagues found that a dominant-active form of the small GTPase Rac1 could disrupt cell-cell adhesion in keratinocytes. This was associated with the endocytosis of E-cadherin through a pathway that appeared to be distinct from the uptake of transferrin, which is clathrin-mediated, and through structures that co-localized with caveolin
In contrast, Bryant and colleagues characterized the EGF-induced internalization of E-cadherin in a breast carcinoma cell line, in which E-cadherin was internalized along with the cadherin-binding proteins p120 and ??-catenin, as Rac1-modulated macropinocytosis
em_re1486( EMT Senescence  map ):
Cadherin internalization can occur through either clathrin-mediated, caveolin-mediated, or macropinocytosis-like pathways. Internalized cadherin is then sorted either for lysosomal degradation or recycling back to the plasma membrane.

E-Cadherin*@Cytoplasm

References
su_wnc1_s_wnc4_re31( Survival  map ):
binding of G-alpha12 toE-cadherin results of loss of binding of b-catenin from the adherence junction
PMID:11136230
su_wnc1_s_wnc4_re24( Survival  map ):
Complex of G-alpha12 and p120 stabilises binding of E-cadherin in Adhesion-complex. G-alpha12 is found back in complex with p120 and E-cadherin
PMID:15240885
su_wca1_s_wca2_re53:( Survival  map ) PMID:10671551 PMID:10837139

E-Cadherin*|​pho@Endosome

References
s_wca1_re42:( Survival  map ) PMID:21606194

E-Cadherin*@Cytoplasm

Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / WNT_CANONICAL  map

References
s_wnc4_re31( Survival  map ):
binding of G-alpha12 toE-cadherin results of loss of binding of b-catenin from the adherence junction
PMID:11136230
s_wca2_re53:( Survival  map ) PMID:10671551 PMID:10837139
s_wnc4_re24( Survival  map ):
Complex of G-alpha12 and p120 stabilises binding of E-cadherin in Adhesion-complex. G-alpha12 is found back in complex with p120 and E-cadherin
PMID:15240885

E-Cadherin*|​S840_pho|​S853_pho|​S855_pho@Cytoplasm

Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / WNT_CANONICAL  map

References
s_wca2_re53:( Survival  map ) PMID:10671551 PMID:10837139

E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho@Cytoplasm

Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / WNT_CANONICAL  map

References
s_wca2_re54:( Survival  map ) PMID:10671551
s_wca2_re50:( Survival  map ) PMID:22659456 PMID:22007144 PMID:19171760 PMID:10931041
s_wca2_re67:( Survival  map ) PMID:22370635

E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho@Cytoplasm

Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / WNT_CANONICAL  map

Modifications:
In compartment: Caveolin vesicle
  1. E-Cadherin*@Caveolin vesicle map
  2. E-Cadherin*|​Y_pho@Caveolin vesicle map
In compartment: Clathrin coated vesicle
  1. E-Cadherin*@Clathrin coated vesicle map
  2. E-Cadherin*|​Y_pho@Clathrin coated vesicle map
In compartment: Cytoplasm
  1. E-Cadherin*@Cytoplasm map
  2. E-Cadherin*@Cytoplasm map
  3. E-Cadherin*|​S840_pho|​S853_pho|​S855_pho@Cytoplasm map
  4. E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho@Cytoplasm map
  5. E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho@Cytoplasm map
In compartment: Cytosol
  1. E-Cadherin*@Cytosol map
  2. E-Cadherin*|​hm2@Cytosol map
  3. E-Cadherin*|​S_pho@Cytosol map
  4. E-Cadherin*|​S_pho@Cytosol map
  5. E-Cadherin*|​Y_pho@Cytosol map
In compartment: Endosome
  1. E-Cadherin*@Endosome map
  2. E-Cadherin*|​pho@Endosome map
  3. E-Cadherin*|​Y_pho@Endosome map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. E-Cadherin*@INNATE_IMMUNE_CELL_Cytosol map
In compartment: Lysosome
  1. E-Cadherin*@Lysosome map
  2. E-Cadherin*|​Y_pho@Lysosome map
In compartment: Macropinosome
  1. E-Cadherin*@Macropinosome map
  2. E-Cadherin*|​Y_pho@Macropinosome map
In compartment: Neighbouring Cell
  1. E-Cadherin*@Neighbouring Cell map
  2. E-Cadherin*|​hm2@Neighbouring Cell map
In compartment: Nucleus
  1. E-Cadherin*@Nucleus map
Participates in complexes:
In compartment: Cytoplasm
  1. E-Cadherin*:​G_alpha__sub_12_endsub_*@Cytoplasm map
  2. E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho:​ITGA9@Cytoplasm map
  3. E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho:​ITGA9:​_beta_-Catenin*|​pho@Cytoplasm map
  4. E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho:​ITGA9:​_beta_-Catenin*|​Y654_pho|​pho@Cytoplasm map
  5. E-Cadherin*:​_alpha_-Catenin*:​cytoskeleton:​p120*@Cytoplasm map
  6. Cytoskeleton:​E-Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*:​p120*@Cytoplasm map
  7. Cytoskeleton:​E-Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*|​Y142_pho:​p120*@Cytoplasm map
  8. E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho:​ITGA3:​TGFB1:​TGFBR*:​_beta_-Catenin*|​pho:​p120*@Cytoplasm map
  9. E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​WNT*@Cytoplasm map
  10. Cytoskeleton:​E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho:​ECM or cell-cell contact:​ITGA3:​_alpha_-Catenin*:​_beta_-Catenin*|​pho:​p120*@Cytoplasm map
  11. E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*:​WNT*@Cytoplasm map
  12. CRIPTO-1*:​E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*:​WNT*@Cytoplasm map
  13. CK1_epsilon_*:​E-Cadherin*:​FZD*:​GTP:​G_alpha_*:​G_beta_*:​G_gamma_*:​LRP5_6*:​WNT*:​p120*@Cytoplasm map
  14. CK1_epsilon_*:​E-Cadherin*:​FZD*:​GTP:​G_alpha_*:​G_beta_*:​G_gamma_*:​LGR5:​LRP5_6*:​RSPO1-4*:​WNT*:​p120*@Cytoplasm map
In compartment: Cytosol
  1. E-Cadherin*|​hm2:​ITGAE:​ITGB7@Cytosol map
In compartment: Endosome
  1. E-Cadherin*:​ITGA3:​TGFB1:​TGFBR*:​p120*@Endosome map
  2. E-Cadherin*:​ITGA3:​TGFB1:​TGFBR*:​_beta_-Catenin*|​pho:​p120*@Endosome map
  3. E-Cadherin*:​ITGA3:​TGFB1:​TGFBR*:​_beta_-Catenin*|​Y654_pho|​pho:​p120*@Endosome map
  4. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  5. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  6. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  7. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  8. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*|​S268_pho|​S269_pho@Endosome map
  9. AMER1*:​APC:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. E-Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*@INNATE_IMMUNE_CELL_Cytosol map
In compartment: Nucleus
  1. APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​E-Cadherin*@Nucleus map
  2. APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​E-Cadherin*|​pho@Nucleus map
In compartment: Vaceolae
  1. CK1_epsilon_*:​E-Cadherin*:​LRP5_6*:​p120*@Vaceolae map
  2. CK1_epsilon_*:​E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​p120*@Vaceolae map
  3. AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae map
  4. AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae map
Participates in reactions:
As Reactant or Product:
  1. E-Cadherin*@Nucleus map + APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*@Nucleus map → map APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​E-Cadherin*@Nucleus map
  2. APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​E-Cadherin*@Nucleus map → map APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​E-Cadherin*|​pho@Nucleus map
  3. APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​E-Cadherin*|​pho@Nucleus map → map APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​E-Cadherin*@Nucleus map
  4. APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​E-Cadherin*@Nucleus map → map E-Cadherin*@Nucleus map + APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*@Nucleus map
  5. APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​E-Cadherin*@Nucleus map → map M phase exit@Nucleus map
  6. E-Cadherin*@Cytosol map → map E-Cadherin*|​S_pho@Cytosol map
  7. E-Cadherin*@Cytosol map → map E-Cadherin*|​S_pho@Cytosol map
  8. E-Cadherin*@Neighbouring Cell map + E-Cadherin*@Cytosol map → map em_s2519
  9. Plakoglobin binding partners*@Cytosol map → map E-Cadherin*@Cytosol map
  10. Cadherin*@Cytosol map → map E-Cadherin*@Cytosol map
  11. E-Cadherin*|​Y_pho@Lysosome map → map degraded
  12. Cadherin*@Cytosol map → map E-Cadherin*|​S_pho@Cytosol map
  13. Cadherin*@Cytosol map → map E-Cadherin*|​S_pho@Cytosol map
  14. Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*:​p120*@Cytosol map → map E-Cadherin*|​Y_pho@Cytosol map
  15. rE-Cadherin*@Nucleus map → map E-Cadherin*@Cytosol map
  16. E-Cadherin*|​hm2@Cytosol map + ITGAE:​ITGB7@Cytosol map → map E-Cadherin*|​hm2:​ITGAE:​ITGB7@Cytosol map
  17. E-Cadherin*|​hm2:​ITGAE:​ITGB7@Cytosol map → map Exocytosis@Neighbouring Cell map
  18. E-Cadherin*@Cytosol map → map E-Cadherin*|​hm2@Cytosol map
  19. E-Cadherin*@Neighbouring Cell map → map E-Cadherin*|​hm2@Neighbouring Cell map
  20. Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*:​p120*@Cytosol map → map E-Cadherin*@Clathrin coated vesicle map
  21. E-Cadherin*|​Y_pho@Clathrin coated vesicle map → map E-Cadherin*|​Y_pho@Endosome map
  22. E-Cadherin*|​Y_pho@Cytosol map → map E-Cadherin*|​Y_pho@Clathrin coated vesicle map
  23. E-Cadherin*@Clathrin coated vesicle map → map E-Cadherin*@Endosome map
  24. E-Cadherin*|​Y_pho@Endosome map → map E-Cadherin*|​Y_pho@Lysosome map
  25. E-Cadherin*@Endosome map → map E-Cadherin*@Lysosome map
  26. E-Cadherin*@Lysosome map → map degraded
  27. E-Cadherin*|​Y_pho@Cytosol map → map E-Cadherin*|​Y_pho@Caveolin vesicle map
  28. E-Cadherin*|​Y_pho@Cytosol map → map E-Cadherin*|​Y_pho@Macropinosome map
  29. Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*:​p120*@Cytosol map → map E-Cadherin*@Caveolin vesicle map
  30. Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*:​p120*@Cytosol map → map E-Cadherin*@Macropinosome map
  31. E-Cadherin*@Caveolin vesicle map → map E-Cadherin*@Endosome map
  32. E-Cadherin*@Macropinosome map → map E-Cadherin*@Endosome map
  33. E-Cadherin*|​Y_pho@Caveolin vesicle map → map E-Cadherin*|​Y_pho@Endosome map
  34. E-Cadherin*|​Y_pho@Macropinosome map → map E-Cadherin*|​Y_pho@Endosome map
  35. E-Cadherin*@Endosome map → map Cadherin*@Cytosol map
  36. E-Cadherin*|​S_pho@Cytosol map → map Adherens junctions@Cytosol map
  37. E-Cadherin*|​S_pho@Cytosol map → map Adherens junctions@Cytosol map
  38. E-Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*@INNATE_IMMUNE_CELL_Cytosol map → map _beta_-Catenin*@INNATE_IMMUNE_CELL_Cytosol map + E-Cadherin*@INNATE_IMMUNE_CELL_Cytosol map + _alpha_-Catenin*@INNATE_IMMUNE_CELL_Cytosol map
  39. WNT*@default map + CK1_epsilon_*:​E-Cadherin*:​LRP5_6*:​p120*@Vaceolae map + FZD*:​GDP:​G_alpha_o*:​G_beta_*:​G_gamma_*@Cytoplasm map + GTP@Vaceolae map + PRR*@Cytoplasm map → map CK1_epsilon_*:​E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​p120*@Vaceolae map + GDP@Vaceolae map
  40. DVL*|​pho|​emp|​emp:​G_beta_*:​G_gamma_*:​_beta_-Arrestin2*@Cytoplasm map + CK1_epsilon_*:​E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​p120*@Vaceolae map + AMER1*:​CK1_gamma_*:​PtdIns(4,5)-P2@Cytoplasm map → map AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae map + GTP:​G_alpha_o*@Cytoplasm map + G_beta_*:​G_gamma_*@Cytoplasm map
  41. AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae map → map AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae map
  42. AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae map + AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Cytoplasm map → map AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  43. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map → map AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  44. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map + AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Cytoplasm map → map AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  45. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map → map AMER1*:​APC:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  46. AMER1*:​APC:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map → map AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  47. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map → map AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*|​S268_pho|​S269_pho@Endosome map
  48. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*|​S268_pho|​S269_pho@Endosome map → map CK1_epsilon_*:​p120*|​S268_pho|​S269_pho@Endosome map + E-Cadherin*|​pho@Endosome map + AMER1*:​AXIN*:​CK1_alpha_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome map
  49. E-Cadherin*|​pho@Endosome map → map Recycling @Cytoplasm map
  50. E-Cadherin*|​pho@Endosome map → map Degradation@Cytoplasm map
  51. E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*:​WNT*@Cytoplasm map → map LRP5_6*@Cytoplasm map + E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​WNT*@Cytoplasm map
  52. LRP5_6*@Cytoplasm map → map E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*:​WNT*@Cytoplasm map
  53. Cytoskeleton:​E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho:​ECM or cell-cell contact:​ITGA3:​_alpha_-Catenin*:​_beta_-Catenin*|​pho:​p120*@Cytoplasm map + TGFB1:​TGFBR*@Cytoplasm map → map E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho:​ITGA3:​TGFB1:​TGFBR*:​_beta_-Catenin*|​pho:​p120*@Cytoplasm map + ECM or cell-cell contact@default map
  54. E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho:​ITGA3:​TGFB1:​TGFBR*:​_beta_-Catenin*|​pho:​p120*@Cytoplasm map → map E-Cadherin*:​ITGA3:​TGFB1:​TGFBR*:​_beta_-Catenin*|​pho:​p120*@Endosome map
  55. E-Cadherin*:​ITGA3:​TGFB1:​TGFBR*:​_beta_-Catenin*|​pho:​p120*@Endosome map → map E-Cadherin*:​ITGA3:​TGFB1:​TGFBR*:​_beta_-Catenin*|​Y654_pho|​pho:​p120*@Endosome map
  56. E-Cadherin*:​ITGA3:​TGFB1:​TGFBR*:​_beta_-Catenin*|​Y654_pho|​pho:​p120*@Endosome map → map E-Cadherin*:​ITGA3:​TGFB1:​TGFBR*:​p120*@Endosome map + _beta_-Catenin*|​Y654_pho@Cytoplasm map
  57. E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*:​WNT*@Cytoplasm map → map WNT canonical pathway@Cytoplasm map
  58. ECM or cell-cell contact@default map + E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho@Cytoplasm map + p120*@Cytoplasm map + ITGA3@Cytoplasm map + Cytoskeleton@Cytoplasm map + _alpha_-Catenin*@Cytoplasm map + _beta_-Catenin*|​pho@Cytoplasm map → map Cytoskeleton:​E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho:​ECM or cell-cell contact:​ITGA3:​_alpha_-Catenin*:​_beta_-Catenin*|​pho:​p120*@Cytoplasm map
  59. E-Cadherin*@Cytoplasm map → map E-Cadherin*|​S840_pho|​S853_pho|​S855_pho@Cytoplasm map
  60. E-Cadherin*|​S840_pho|​S853_pho|​S855_pho@Cytoplasm map → map E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho@Cytoplasm map
  61. ITGA9@Cytoplasm map + _beta_-Catenin*|​pho@Cytoplasm map + E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho@Cytoplasm map → map E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho:​ITGA9:​_beta_-Catenin*|​pho@Cytoplasm map
  62. E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho:​ITGA9:​_beta_-Catenin*|​pho@Cytoplasm map → map E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho:​ITGA9:​_beta_-Catenin*|​Y654_pho|​pho@Cytoplasm map
  63. E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho:​ITGA9:​_beta_-Catenin*|​Y654_pho|​pho@Cytoplasm map → map E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho:​ITGA9@Cytoplasm map + _beta_-Catenin*|​Y654_pho@Cytoplasm map
  64. CRIPTO-1*:​E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*:​WNT*@Cytoplasm map → map WNT canonical pathway@Cytoplasm map
  65. E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​WNT*@Cytoplasm map + CRIPTO-1*:​LRP5_6*@Cytoplasm map → map CRIPTO-1*:​E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*:​WNT*@Cytoplasm map
  66. LGR5:​RSPO1-4*@Cytoplasm map + CK1_epsilon_*:​E-Cadherin*:​FZD*:​GTP:​G_alpha_*:​G_beta_*:​G_gamma_*:​LRP5_6*:​WNT*:​p120*@Cytoplasm map → map CK1_epsilon_*:​E-Cadherin*:​FZD*:​GTP:​G_alpha_*:​G_beta_*:​G_gamma_*:​LGR5:​LRP5_6*:​RSPO1-4*:​WNT*:​p120*@Cytoplasm map
  67. CK1_epsilon_*:​E-Cadherin*:​FZD*:​GTP:​G_alpha_*:​G_beta_*:​G_gamma_*:​LGR5:​LRP5_6*:​RSPO1-4*:​WNT*:​p120*@Cytoplasm map → map WNT canonical pathway@Cytoplasm map
  68. E-Cadherin*@Cytoplasm map + p120*@Cytoplasm map + _alpha_-Catenin*@Cytoplasm map + _beta_-Catenin*@Cytoplasm map + Cytoskeleton@Cytoplasm map → map Cytoskeleton:​E-Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*:​p120*@Cytoplasm map
  69. E-Cadherin*@Cytoplasm map + G_alpha__sub_12_endsub_*@Cytoplasm map → map E-Cadherin*:​G_alpha__sub_12_endsub_*@Cytoplasm map
  70. Cytoskeleton:​E-Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*:​p120*@Cytoplasm map → map _beta_-Catenin*@Cytoplasm map + p120*@Cytoplasm map + E-Cadherin*@Cytoplasm map + _alpha_-Catenin*@Cytoplasm map
  71. Cytoskeleton:​E-Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*:​p120*@Cytoplasm map → map Cytoskeleton:​E-Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*|​Y142_pho:​p120*@Cytoplasm map
  72. Cytoskeleton:​E-Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*|​Y142_pho:​p120*@Cytoplasm map → map _beta_-Catenin*|​Y142_pho@Cytoplasm map + E-Cadherin*:​_alpha_-Catenin*:​cytoskeleton:​p120*@Cytoplasm map
As Catalyser:
  1. M phase@Nucleus map → map G1 phase@Nucleus map
  2. CyclinA1*@Nucleus map → map degraded
  3. CyclinB1*@Nucleus map → map degraded
  4. CDC25A@Nucleus map → map degraded
  5. AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae map → map AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae map
  6. AMER1*:​APC:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map → map AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  7. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map → map AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*|​S268_pho|​S269_pho@Endosome map
  8. DVL*@Cytoplasm map + CUL3:​KLHL*:​RBX1@Cytoplasm map → map CUL3:​DVL*:​KLHL*:​RBX1@Cytoplasm map
  9. JBN*:​_beta_-Catenin*@Cytoplasm map → map JBN*:​_beta_-Catenin*@Cilium map
  10. JBN*:​_beta_-Catenin*@Cilium map → map su_wca1_s_wca1_s764
  11. ATP6V0C_D*@Vaceolae map → map ATP6V0C_D*@Vaceolae map
  12. SRC@Cytoplasm map → map SRC@Cytoplasm map
  13. Cytoskeleton:​E-Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*:​p120*@Cytoplasm map → map _beta_-Catenin*@Cytoplasm map + p120*@Cytoplasm map + E-Cadherin*@Cytoplasm map + _alpha_-Catenin*@Cytoplasm map