Protein LEF1_TCF3_4* map

Identifiers
LEF/TCF3*
transcription factor 4
HUGO:TCF4, HGNC:11634, ENTREZ:6925, UNIPROT:P15884, GENECARDS:GC18M052889
lymphoid enhancer-binding factor 1
HUGO:LEF1, HGNC:6551, ENTREZ:51176, UNIPROT:Q9UJU2, GENECARDS:GC04M108968
transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
HUGO:TCF3, HGNC:11633, ENTREZ:6929, UNIPROT:P15923, GENECARDS:GC19M001609??

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CELL_CELL_ADHESIONS  map
 EMT Senescence  map  / ADHERENS_JUNCTIONS  map

LEF1_TCF3_4*@Nucleus

References
em_emtc_emtc_re527( EMT Senescence  map ):
PMID:19751508
PMID:22270359
PMID:16940750
-In the absence of Wnt ligands, b-catenin is phosphorylated by CK1 and GSK-3 in the context of a destruction complex with APC and Axin.
Phosphorylated b-catenin is consequently targeted for ubiquitination and degraded.
-In the presence of Wnt lignads, upon ligand binding, DVL1 (dishevelled) recruits the Axin-GSK-3 complex, resulting in the sequential phosphorylation of LRP6 by CK1 and GSK-3.
Phoshorylated LRP6 serves as a docking site for additional Axin-GSK-3 complex, resulting in the disassembly of the destruction complex.
Non phosphorylated and thus stabilized b-catenin translocates to the nucleus where it activates transcription of target genes together with LEF/TCFs
PMID:19020303
When Wnt binds its receptor, Frizzled, beta-catenin is released to translocate from the cytoplasm to the nucleus, where it forms a complex with TCF and/or LEF transcription factors and stimulates cyclin D1 gene transcription
(Beta-catenin/TCF)- mediated cyclin D1 gene transcription is further regulated by active Rac signaling, phosphorylation by protein kinase A (PKA)
PMID:15377999
Rac1-GTP augments nuclear accumulation of b-catenin and physical association of Rac1 with b-catenin and/or TCF-4 may facilitate this process.
This culminates in the amplification of b-catenin signaling activity, resulting in enhanced transcriptional activation of perhaps a specific subset of Wnt target genes important in cancer progression.
PMID:15082531
The activation of MP3K7(TAK1) by TAB1 activates NLK. the TAK1???NLK MAPK pathway regulates Wnt signaling by phosphorylating TCF in mammalian cells.
NLK phosphorylates TCF/LEF factors and inhibits the interaction of the beta-catenin???TCF complex with DNA.
em_emtc_emtc_re620( EMT Senescence  map ):
PMID:17143293
The size of the LEF/TCF family is small: approximately 4 members in vertebrates.
The LEF/TCF family exhibits extensive patterns of alternative splicing, alternative promoter usage and activities of both repression and activation.
All LEF/TCFs bind b-catenin.
PMID:17143294

Modifications:
In compartment: Nucleus
  1. LEF1_TCF3_4*@Nucleus map
Participates in complexes:
In compartment: Nucleus
  1. LEF1_TCF3_4*:​_beta_-Catenin*@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. LEF1_TCF3_4*@Nucleus map → map TCF3@Nucleus map
  2. LEF1_TCF3_4*@Nucleus map + _beta_-Catenin*@Cytosol map → map LEF1_TCF3_4*:​_beta_-Catenin*@Nucleus map
  3. LEF1_TCF3_4*@Nucleus map → map LEF1@Nucleus map
  4. LEF1_TCF3_4*@Nucleus map → map TCF4@Nucleus map
As Catalyser:
  1. gMYC@Nucleus map → map rMYC@Nucleus map
  2. gMIR183@Nucleus map → map arMIR183@Nucleus map
  3. gID2@Nucleus map → map rID2@Nucleus map
  4. gAXIN2@Nucleus map → map rAXIN2@Nucleus map
  5. gSNAI2@Nucleus map → map rSNAI2@Nucleus map
  6. gCyclinD1*@Nucleus map → map rCyclinD1*@Nucleus map
  7. gClaudin1*@Nucleus map → map rClaudin1*@Nucleus map
  8. gClaudin2*@Nucleus map → map rClaudin2*@Nucleus map
  9. gMMP14@Nucleus map → map rMMP14@Nucleus map
  10. gFibronectin*@Nucleus map → map rFibronectin*@Nucleus map
  11. gmiR96@Nucleus map → map armiR96@Nucleus map
  12. gmiR182@Nucleus map → map armiR182@Nucleus map