Gene Claudin1* map

Identifiers
claudin 1
HUGO:CLDN1, HGNC:2032, ENTREZ:9076, GENECARDS:GC03M190023

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CELL_CELL_ADHESIONS  map
 EMT Senescence  map  / TIGHT_JUNCTIONS  map

gClaudin1*@Nucleus

References
em_emtc_emtc_re523( EMT Senescence  map ):
PMID:12668723
Snail binds directly to the E-boxes of the promoters of claudin et occludin genes, resulting in complete repression of their promoter activity
PMID:16232121
Snail and Slug bind to the E-box motifs present in the human Claudin-1 promoter.
High levels of Snail and Slug correlatedwith lowlevels of Claudin-1 expression.
It is proposed that Claudin-1 is a direct downstream target gene of Snail family factors in epithelial cells
PMID:15151915
The transcription factors B-catenin/Tcf complex has been shown to bind directly to the claudin-1 and claudin-2 promoters.
PMID:17550342
SNAI2 represses Claudin-1 expression
SNAI1 represses Claudin-1 expression

Modifications:
In compartment: Nucleus
  1. gClaudin1*@Nucleus map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gClaudin1*@Nucleus map → map rClaudin1*@Nucleus map
    As Catalyser: