Protein ITGA3 map

Identifiers
integrin subunit alpha 3
HUGO:ITGA3 hgnc_id:HGNC:6139 HGNC:6139 ENTREZ:3675 UNIPROT:P26006
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
"antigen identified by monoclonal antibody J143", MSK18
HUGO:ITGA3 HGNC:6139 ENTREZ:3675 UNIPROT:P26006
HUGO:ITGA3 HGNC:6139 ENTREZ:3675 UNIPROT:P26006 GENECARDS:ITGA3 REACTOME:57565 KEGG:3675 ATLASONC:GC_ITGA3 WIKI:ITGA3

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CELL_MATRIX_ADHESIONS  map
 EMT Senescence  map  / ECM  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / WNT_CANONICAL  map

References
CASCADE:INTEGRIN
PMID:21666923
Integrin ??3 blockade enhances microtopographical down-regulation of ??-smooth muscle actin: role of microtopography in ECM regulation.
PMID:18037882
Integrin a3 and a5 are important in leading fibroblasts in SCC.
siRNA against integrin 3 or integrin 5 in stromal fibroblasts would prevent the invasion of SCC cells and Figure 4C shows that siRNA-mediated depletion of either integrin 3 or integrin 5 in stromal fibroblasts, but not in SCC cells, reduced the collective invasion of SCC cells.

ITGA3@Cytoplasm

Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / WNT_CANONICAL  map

References
s_wca2_re50:( Survival  map ) PMID:22659456 PMID:22007144 PMID:19171760 PMID:10931041

Modifications:
In compartment: Cytoplasm
  1. ITGA3@Cytoplasm map
In compartment: Cytosol
  1. ITGA3@Cytosol map
Participates in complexes:
In compartment: Cytoplasm
  1. E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho:​ITGA3:​TGFB1:​TGFBR*:​_beta_-Catenin*|​pho:​p120*@Cytoplasm map
  2. Cytoskeleton:​E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho:​ECM or cell-cell contact:​ITGA3:​_alpha_-Catenin*:​_beta_-Catenin*|​pho:​p120*@Cytoplasm map
In compartment: Endosome
  1. E-Cadherin*:​ITGA3:​TGFB1:​TGFBR*:​p120*@Endosome map
  2. E-Cadherin*:​ITGA3:​TGFB1:​TGFBR*:​_beta_-Catenin*|​pho:​p120*@Endosome map
  3. E-Cadherin*:​ITGA3:​TGFB1:​TGFBR*:​_beta_-Catenin*|​Y654_pho|​pho:​p120*@Endosome map
Participates in reactions:
As Reactant or Product:
  1. ITGA3@Cytosol map + ITGB1@Cytosol map → map ca_s4784
  2. rITGA3@Nucleus map → map ITGA3@Cytosol map
  3. ITGA3@Cytosol map + ITGB1@Cytosol map → map em_emtc_emtc_s3086
  4. Cytoskeleton:​E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho:​ECM or cell-cell contact:​ITGA3:​_alpha_-Catenin*:​_beta_-Catenin*|​pho:​p120*@Cytoplasm map + TGFB1:​TGFBR*@Cytoplasm map → map E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho:​ITGA3:​TGFB1:​TGFBR*:​_beta_-Catenin*|​pho:​p120*@Cytoplasm map + ECM or cell-cell contact@default map
  5. E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho:​ITGA3:​TGFB1:​TGFBR*:​_beta_-Catenin*|​pho:​p120*@Cytoplasm map → map E-Cadherin*:​ITGA3:​TGFB1:​TGFBR*:​_beta_-Catenin*|​pho:​p120*@Endosome map
  6. E-Cadherin*:​ITGA3:​TGFB1:​TGFBR*:​_beta_-Catenin*|​pho:​p120*@Endosome map → map E-Cadherin*:​ITGA3:​TGFB1:​TGFBR*:​_beta_-Catenin*|​Y654_pho|​pho:​p120*@Endosome map
  7. E-Cadherin*:​ITGA3:​TGFB1:​TGFBR*:​_beta_-Catenin*|​Y654_pho|​pho:​p120*@Endosome map → map E-Cadherin*:​ITGA3:​TGFB1:​TGFBR*:​p120*@Endosome map + _beta_-Catenin*|​Y654_pho@Cytoplasm map
  8. ECM or cell-cell contact@default map + E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho@Cytoplasm map + p120*@Cytoplasm map + ITGA3@Cytoplasm map + Cytoskeleton@Cytoplasm map + _alpha_-Catenin*@Cytoplasm map + _beta_-Catenin*|​pho@Cytoplasm map → map Cytoskeleton:​E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho:​ECM or cell-cell contact:​ITGA3:​_alpha_-Catenin*:​_beta_-Catenin*|​pho:​p120*@Cytoplasm map
As Catalyser:
  1. SRC@Cytoplasm map → map SRC@Cytoplasm map