Phenotype EMT map
EMT@Cytosol

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CYTOSKELETON_POLARITY  map
 EMT Senescence  map  / CELL_CELL_ADHESIONS  map
 EMT Senescence  map  / CELL_MATRIX_ADHESIONS  map
 EMT Senescence  map  / ECM  map
 EMT Senescence  map  / TIGHT_JUNCTIONS  map
 EMT Senescence  map  / GAP_JUNCTIONS  map
 EMT Senescence  map  / ADHERENS_JUNCTIONS  map
 EMT Senescence  map  / DESMOSOMES  map

References
em_emtc_emtc_re675( EMT Senescence  map ):
GJB5 is so-called Connexin 31.1
PMID:21777377
Expression of Cx31.1 reduced mesenchymal marker vimentin level and increased epithelial marker cytokeratin 18 level, indicating that Cx31.1 may regulate molecular pathways leading to a reverse of the EMT process.
Cx31.1overexpression slightly up-regulated E-cadherin expression, indicating that Cx31.1 overexpression mediate only a partial reversion to an epithelial phenotype of NSCLC cells.

EMT@Nucleus

Identifiers
Link to EMTmap

References
PARP1 poly(ADP)ribosylates SNAI1 and activates it and EMT program
PMID:21577210

EMT@Cytoplasm

References
su_wnc1_s_wnc1_re75:( Survival  map ) PMID:19577357
su_wnc1_s_wnc2_re23( Survival  map ):
Calpain might be involved in EMT as it can proteolyse many proteins that are involved in cell adhesion.
PMID:16129881

Modifications:
In compartment: Cytoplasm
  1. EMT@Cytoplasm map
  2. EMT@Cytoplasm map
In compartment: Cytosol
  1. EMT@Cytosol map
In compartment: Nucleus
  1. EMT@Nucleus map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. SNAI1|​unk@Nucleus map → map EMT@Nucleus map
    2. EMT@Cytosol map → map Gap junctions@Cytosol map
    3. GJB5@Cytosol map → map EMT@Cytosol map
    4. EMT@Cytosol map → map Self-renewal@Cytosol map
    5. EMT@Cytosol map → map Invasiveness@Cytosol map
    6. EMT@Cytosol map → map Apoptosis@Cytosol map
    7. Cytoskeleton remodeling@Nucleus map → map EMT@Cytosol map
    8. Migratory polarity@Nucleus map → map EMT@Cytosol map
    9. Cell-cell adhesions@Neighbouring Cell map → map EMT@Cytosol map
    10. rMMP11@Nucleus map → map EMT@Nucleus map
    11. rFOXF1@Nucleus map → map EMT@Nucleus map
    12. rFOXC2@Nucleus map → map EMT@Nucleus map
    13. rFOXQ1@Nucleus map → map EMT@Nucleus map
    14. rSNAI1@Nucleus map → map EMT@Nucleus map
    15. GTP:​RAC1@Cytosol map → map EMT@Cytosol map
    16. SMAD2|​pho:​_beta_-Catenin*|​Y654_pho@Nucleus map → map EMT@Nucleus map
    17. RACK1*:​VANGL*@Cytoplasm map → map EMT@Cytoplasm map
    18. DACT1:​VANGL*@Cytoplasm map → map EMT@Cytoplasm map
    19. Calpain*@Cytoplasm map → map EMT@Cytoplasm map
    20. SNAI1|​pho@Nucleus map → map EMT@Nucleus map
    As Catalyser: