Protein _beta_-Catenin*_p120*1_Plakoglobin*_Plakophilin4* map

Identifiers
_beta_-Catenin*_p120*_JUP_PKP4*
catenin (cadherin-associated protein), beta 1, 88kDa
HUGO:CTNNB1, HGNC:2514, ENTREZ:1499, UNIPROT:P35222, GENECARDS:GC03P041236
catenin (cadherin-associated protein), delta 1
HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716
junction plakoglobin
"catenin (cadherin-associated protein), gamma 80kDa", CTNNG
HUGO:JUP HGNC:6207 ENTREZ:3728 UNIPROT:P14923
plakophilin 4
HUGO:PKP4 HGNC:9026 ENTREZ:8502 UNIPROT:Q99569

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CELL_CELL_ADHESIONS  map
 EMT Senescence  map  / DESMOSOMES  map

References
PMID:10685062
Adherens junctions are ubiquitously expressed in endothelia of all vascular beds?
Adherens junction in endothelila cells are formed by homofilic binding of VE-cahderin (cadherin-5)
Cadherins are cell adhesion molecules anchored by their cytoplasmic tails to a network of intracellular cytoplasmic proteins connected to the actin-based microfilament system.
Association with catenins is nessesary for cadherin-mediated cell adhesion.
PMID:12426320
VE-cadhein interacts with catenin delta 1 (p120-catenin, CTNND1)
VE-cadhein interacts with Plakophilin 4 (PKP4)
PMID:7962210
VE-cadhein interacts with catenin beta 1 (CTNNB1)
PKP4 and CTNND1 bind to the same region on the cytoplasmic tail of VE-cadherin.
Overexpression of PKP4 can displace CTNND1 from intercellular junctions.
PMID:9739078
VE-cadhein interacts with Plakoglobin (JUP)

_beta_-Catenin*_p120*1_Plakoglobin*_Plakophilin4*@Cytosol

References
em_emtc_emtc_re1006( EMT Senescence  map ):
PMID:10685062
Adherens junctions are ubiquitously expressed in endothelia of all vascular beds?
Adherens junction in endothelila cells are formed by homofilic binding of VE-cahderin (cadherin-5)
Cadherins are cell adhesion molecules anchored by their cytoplasmic tails to a network of intracellular cytoplasmic proteins connected to the actin-based microfilament system.
Association with catenins is nessesary for cadherin-mediated cell adhesion.
PMID:12426320
VE-cadhein interacts with catenin delta 1 (p120-catenin, CTNND1)
VE-cadhein interacts with Plakophilin 4 (PKP4)
PMID:7962210
VE-cadhein interacts with catenin beta 1 (CTNNB1)
PKP4 and CTNND1 bind to the same region on the cytoplasmic tail of VE-cadherin.
Overexpression of PKP4 can displace CTNND1 from intercellular junctions.
PMID:9739078
VE-cadhein interacts with Plakoglobin (JUP)

Modifications:
In compartment: Cytosol
  1. _beta_-Catenin*_p120*1_Plakoglobin*_Plakophilin4*@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. VE-Cadherin*:​_beta_-Catenin*_p120*1_Plakoglobin*_Plakophilin4*@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. VE-Cadherin*@Cytosol map + _beta_-Catenin*_p120*1_Plakoglobin*_Plakophilin4*@Cytosol map → map VE-Cadherin*:​_beta_-Catenin*_p120*1_Plakoglobin*_Plakophilin4*@Cytosol map
  2. VE-Cadherin*:​_beta_-Catenin*_p120*1_Plakoglobin*_Plakophilin4*@Cytosol map → map Desmosomes@Cytosol map
  3. _beta_-Catenin*_p120*1_Plakoglobin*_Plakophilin4*@Cytosol map → map Plakophilin4*@Cytosol map
  4. _beta_-Catenin*_p120*1_Plakoglobin*_Plakophilin4*@Cytosol map → map Plakoglobin*@Cytosol map
  5. _beta_-Catenin*_p120*1_Plakoglobin*_Plakophilin4*@Cytosol map → map p120*@Cytosol map
  6. _beta_-Catenin*_p120*1_Plakoglobin*_Plakophilin4*@Cytosol map → map _beta_-Catenin*@Cytosol map
As Catalyser: