Protein NUMB map

Identifiers
protein numb homolog
HUGO:NUMB, HGNC:8060, ENTREZ:8650, UNIPROT:P49757, GENECARDS:GC14M073741
NUMB
HUGO:NUMB HGNC:8060 ENTREZ:8650 UNIPROT:P49757 GENECARDS:NUMB REACTOME:60616 KEGG:8650 ATLASONC:NUMBID43702ch14q24 WIKI:NUMB

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / LYSOSOME_ENDOSOME  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / HEDGEHOG  map

References
PMID:20940030

NUMB@Cytosol

References
em_emtc_emtc_re1322( EMT Senescence  map ):
TGFbeta activates Notch
PMID:22363130
PMID:22330899
em_emtc_emtc_re1328:( EMT Senescence  map ) PMID:21841793
em_emtc_emtc_re1346:( EMT Senescence  map ) PMID:19567869

Modifications:
In compartment: Cytosol
  1. NUMB@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. ITCH:​NUMB@Cytosol map
In compartment: Lysosome
  1. NOTCH1:​NUMB@Lysosome map
  2. JAG1|​ubi:​NOTCH1:​NUMB:​_beta_-Catenin*@Lysosome map
Participates in reactions:
As Reactant or Product:
  1. JAG1|​ubi:​NOTCH1@Neighbouring Cell map + _beta_-Catenin*@Cytosol map + NUMB@Cytosol map → map JAG1|​ubi:​NOTCH1:​NUMB:​_beta_-Catenin*@Lysosome map
  2. NOTCH1@Endosome map + NUMB@Cytosol map → map NOTCH1:​NUMB@Lysosome map
  3. ITCH@Cytosol map + NUMB@Cytosol map → map ITCH:​NUMB@Cytosol map
As Catalyser:
  1. JAG1|​ubi:​NOTCH1@Neighbouring Cell map → map NICD*@Cytosol map
  2. DLL1:​NOTCH1@Neighbouring Cell map → map NICD*@Cytosol map
  3. GLI1@Cytosol map → map GLI1|​ubi|​ubi@Cytosol map