Reaction transcription em_emtc_emtc_re523 map

gClaudin1*@Nucleus map → rClaudin1*@Nucleus map

Reaction regulators:
Inhibition
  1. CTBP1_2*:​HDAC1:​HDAC3:​SNAI2@Nucleus map
Physical_stimulation
  1. LEF1_TCF3_4*:​_beta_-Catenin*@Nucleus map
Unknown_inhibition
  1. SNAI1@Nucleus map
  2. SNAI2@Nucleus map


References
PMID:12668723
Snail binds directly to the E-boxes of the promoters of claudin et occludin genes, resulting in complete repression of their promoter activity
PMID:16232121
Snail and Slug bind to the E-box motifs present in the human Claudin-1 promoter.
High levels of Snail and Slug correlatedwith lowlevels of Claudin-1 expression.
It is proposed that Claudin-1 is a direct downstream target gene of Snail family factors in epithelial cells
PMID:15151915
The transcription factors B-catenin/Tcf complex has been shown to bind directly to the claudin-1 and claudin-2 promoters.
PMID:17550342
SNAI2 represses Claudin-1 expression
SNAI1 represses Claudin-1 expression