Reaction transcription em_emtc_emtc_re67 map

gMMP14@Nucleus map → rMMP14@Nucleus map

Reaction regulators:
Boolean_logic_gate_and
  1. em_emtc_emtc_s1611 and SP1|​pho|​active@Nucleus map
Physical_stimulation
  1. em_emtc_emtc_s1611
  2. LEF1_TCF3_4*:​_beta_-Catenin*@Nucleus map
  3. NF-_kappa_B pathway@Cytosol map
  4. SP1|​pho|​active@Nucleus map


References
PMID:15592504
PMID:16716598
SP1 and HIF1 complex (HIF2_alpha_ and HIF1_beta_) cooperatively induce MMP1 transcriptional expression
PMID:20589835
Our results indicate that MT1-MMP is a direct down-stream target in the Wnt signaling pathway, and that one of the ways accumulated beta-catenin contributes to colorectal carcinogenesis is by transactivating this gene.
MT1-MMP is one target gene of Lef-1/Tcf-4 (Takahashi et al, 2002)
PMID:16556862
NF-??B is an important transcriptional factor of MT1-MMP expression