Complex NFKB1_p50*:RELA map
Complex composition:

  1. NFKB1_p50* map
  2. RELA map

NFKB1_p50*:​RELA@Nucleus

Identifiers
NAME:NFKB1_p50*:RELA

References
rc_re1379:( Regulated Cell Death  map ) reactionType:is.a

NFKB1_p50*:​RELA@Cytosol

Identifiers
NAME:NFKB1_p50*:RELA

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / CORE  map

References
PMID:20138012
NF-??B heterodimer (RelA-p50) translocates to the nucleus, where it activates the transcription of its target genes ( Karin and Ben-Neriah, 2000 and Pereira and Oakley, 2008). Nuclear p65 staining was detected in the stroma of HPV skin sections but not in the skin of nontransgenic control mice
PMID:23831470
we performed immunostaining for the NF-??B subunit p65 (RelA). When active, the NF-??B heterodimer (RelA-p50) translocates to the nucleus, where it activates the transcription of its target genes [31]. Indeed, we found that in addition to its accumulation in the tumor cells, NF-??B was upregulated in CAFs in the stroma of breast and ovarian tumors
ca_re233( Cancer Associated Fibroblasts  map ):
PMID:15145317
The activated IKK complex
catalyzes the phosphorylation of IkBs (at sites
equivalent to Ser32 and Ser36 of IkBa), polyubiquitination
(at sites equivalent to Lys21 and Lys22 of IkBa) and
subsequent degradation by the 26S proteasome. The
released NF-kB dimers (in this pathway, most commonly
the p50??? RelA dimer) translocate to the nucleus, bind DNA
and activate gene transcription.

NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol

Identifiers
NAME:NFKB1_p50*:RELA

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CORE_PATHWAYS  map

References
PMID:12133954
IL2R signaling induces IkBa degradation and formation of heterodimeric p50/p65 NFkB complexes
NF-??B binds to the upstream enhancer of the perforin gene and that this pathway is involved in the activation of perforin expression downstream of NFkB
PMID:12759422, PMID:10679398
IL-18 induces NF-??B binding to the IFN-?? gene promoter and induction of gene expression. Probably via NIK pathway.
PMID:21224476, PMID:12759422
NFKBIZ binds to the IFNG promoter in response to IL-12 and IL-18 and encreases promoter activity.
NFKBIZ regulates IFNG expression by bindingof NF-??B p65/p50 on IFNG promoter .
in_re878( Innate Immunity  map ):
PMID:15145317
The activated IKK complex
catalyzes the phosphorylation of IkBs (at sites
equivalent to Ser32 and Ser36 of IkBa), polyubiquitination
(at sites equivalent to Lys21 and Lys22 of IkBa) and
subsequent degradation by the 26S proteasome. The
released NF-kB dimers (in this pathway, most commonly
the p50??? RelA dimer) translocate to the nucleus, bind DNA
and activate gene transcription.

NFKB1_p50*:​RELA@T_cell

Identifiers
NAME:NFKB1_p50*:RELA

References
PMID:12133954
IL2R signaling induces IkBa degradation and formation of heterodimeric p50/p65 NFkB complexes
NF-??B binds to the upstream enhancer of the perforin gene and that this pathway is involved in the activation of perforin expression downstream of NFkB
PMID:12759422, PMID:10679398
IL-18 induces NF-??B binding to the IFN-?? gene promoter and induction of gene expression. Probably via NIK pathway.
PMID:21224476, PMID:12759422
NFKBIZ binds to the IFNG promoter in response to IL-12 and IL-18 and encreases promoter activity.
NFKBIZ regulates IFNG expression by bindingof NF-??B p65/p50 on IFNG promoter .

Modifications:
Participates in complexes:
In compartment: Cytosol
  1. NFKB1_p50*:​RELA@Cytosol map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map
In compartment: Nucleus
  1. NFKB1_p50*:​RELA@Nucleus map
In compartment: T_cell
  1. NFKB1_p50*:​RELA@T_cell map
Participates in reactions:
As Reactant or Product:
  1. NFKB1_p50*:​RELA@T_cell map → map NFkB*@T_cell map
  2. IkB*|​pho:​NFKB1_p50*:​RELA@T_cell map → map NFKB1_p50*:​RELA@T_cell map + IkB*|​pho@T_cell map
  3. IkB*|​pho:​NFKB1_p50*:​RELA@Cytosol map → map NFKB1_p50*:​RELA@Cytosol map + IkB*|​pho@Cytosol map
  4. NFKB1_p50*:​RELA@Cytosol map → map NFkB*@Cytosol map
  5. NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map → map NFkB*@INNATE_IMMUNE_CELL_Cytosol map
  6. IkB*|​pho:​NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map → map NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map + IkB*|​pho@INNATE_IMMUNE_CELL_Cytosol map
  7. NFKB1_p50*:​RELA:​p100@INNATE_IMMUNE_CELL_Cytosol map → map NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map + p100@INNATE_IMMUNE_CELL_Cytosol map
  8. NFKB1_p50*@Cytosol map + RELA@Cytosol map → map NFKB1_p50*:​RELA@Cytosol map
  9. NFKBIA@Cytosol map + NFKB1_p50*:​RELA@Cytosol map → map rc_s5553
  10. NFKB1_p50*:​RELA@Cytosol map → map NFKB1_p50*:​RELA@Nucleus map
  11. NFKB1_p50*:​RELA@Nucleus map → map NFKB1@Nucleus map
  12. NFKB1_p50*:​RELA@Cytosol map → map Survival@Cytosol map
  13. NFKB1_p50*:​RELA@Cytosol map → map Autophagy survival@Cytosol map
  14. NFKB1_p50*:​RELA@Cytosol map → map Apoptotic death@Cytosol map
  15. NF-_kappa_B pathway@Cytoplasm map → map NFKB1_p50*:​RELA@Nucleus map
  16. _beta_-Catenin*@Nucleus map + NFKB1_p50*:​RELA@Nucleus map → map su_wca1_s_wca3_s281
As Catalyser:
  1. gIL2@T_cell map → map rIL2@T_cell map
  2. gIFNG@T_cell map → map rIFNG@T_cell map
  3. gNOS2@Nucleus map → map rNOS2@Nucleus map