Antisense RNA MIR183 map

Identifiers
microRNA 183
HUGO:MIR183, HGNC:31554, ENTREZ:406959, GENECARDS:GC07M129416
HUGO:MIR183

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
HMC:TUMOR_PROMOTING_INFLAMMATION
 Innate Immunity  map  / MIRNA_TF_IMMUNOSUPPRESSIVE  map

References
 NATURAL_KILLER  map
CASCADE:TGFB
PMID:24586048
Suppression of NK cells is a result of TGF-?? induction of microRNA (miR)-183, which binds and represses DNAX activating protein 12 kDa (DAP12), a signal adaptor for lytic function in NK cells.

arMIR183@Nucleus

References
em_emtc_emtc_re1136( EMT Senescence  map ):
PMID:20706219
Feedback loop: ZEB1 inhibits expression of MIR203 and MIR183
PMID:19935649
ZEB1 directly controls transcription of the miR-203 and miR-183 and miR-200 family genes
PMID:24335145
??-Catenin/TCF/LEF-1 binds to the promoter of miR-183-96-182 cluster gene and thereby activates the transcription of the cluster.
em_emtc_emtc_re1140( EMT Senescence  map ):
BMI1, KLF4 and SOX2 are targets of MIR183

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. arMIR183@INNATE_IMMUNE_CELL_Cytosol map
In compartment: Nucleus
  1. arMIR183@Nucleus map
Participates in complexes:
In compartment: Cytosol
  1. BIM1_KLF4_SOX2*:​MIR183@Cytosol map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. DAP12*:​MIR183@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. gMIR183@Nucleus map → map arMIR183@Nucleus map
  2. arMIR183@Nucleus map + rBIM1_KLF4_SOX2*@Nucleus map → map BIM1_KLF4_SOX2*:​MIR183@Cytosol map
  3. gMIR183@INNATE_IMMUNE_CELL_Cytosol map → map arMIR183@INNATE_IMMUNE_CELL_Cytosol map
  4. DAP12*:​MIR183@INNATE_IMMUNE_CELL_Cytosol map → map degraded
  5. rDAP12*@INNATE_IMMUNE_CELL_Cytosol map + arMIR183@INNATE_IMMUNE_CELL_Cytosol map → map DAP12*:​MIR183@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser: