Identifiers
NAME:BCL9:DVL*:JUN:LEF_TCF*:PYGO*:WRE*:_beta_-Catenin*
References
s_wca3_re6( Survival ):
PMID:16169192
B-catenin competes with TLE for Lef-1
PMID:15768032
CBP-and P300-mediated transcription different cell fates
PMID:20530697
(phosphorylated) C-JUN can bind to TCF4
PMID:18347071 PMID:16007074
s_wca3_re7( Survival ):
The transcription complex containing P300 initiates transcription of genes that are involved in differentiation.
PMID:20920541
The repressor complex is is by default present on the enhancers of wnt-target genes
PMID:16510874
s_wca3_re65( Survival ):
PMID:22761862
Smad1 alone inhibits myc expression while b-catenin/TCF4 activates gene expression. Highest gene expression obtained when SMAD1/b-catenin/TCF4 complex is formed
PMID:15576399
Mi-2/NuRD
PMID:22290435
s_wca3_re154( Survival ):
SOX9
PMID:23306204
p300 transcription complex
PMID:15806138
WNT-target gene:
PMID:20122174
s_wca3_re155( Survival ):
Transcription complex containing b-catenin and P300
PMID:17050667 PMID:21767405
RAD6B is overexpressed in breast cancer
PMID:11929833
RAD6B upregulated in invasive breast cancer
PMID:22705350
s_wca3_re157( Survival ):
BCL9 is a target gene of the wnt pathway.
PMID:18627596
However not known which transcription complex is involved either with CBP or P300. I have chosen this complex randomly
s_wca3_re166( Survival ):
Not known if P300 transcription complex mediates this trancription either it is CBP transcription complex
PMID:17291450
+ BCL9:DVL*:JUN|pho|pho:LEF_TCF*:PYGO*:WRE*:_beta_-Catenin*|K345_ace|ace@Nucleus → APC|T1487_pho:BCL9:CTBP*|hm2:DVL*:HDAC1_2*:JUN|pho|pho:LEF_TCF*:PYGO*:WRE*:_beta_-Catenin*|K345_ace|ace@Nucleus
+ BCL9:DVL*:JUN|pho|pho:PYGO*:_beta_-Catenin*|K345_ace|ace@Nucleus → BCL9:DVL*:JUN|pho|pho:LEF_TCF*:PYGO*:WRE*:_beta_-Catenin*|K345_ace|ace@Nucleus + HDAC1_2*:TLE*|ubi@Nucleus