Identifiers
lymphoid enhancer-binding factor 1
HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2
transcription factor 7 (T-cell specific HMG-box)
HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402
transcription factor 7-like 1 (T-cell specific HMG-box)
TCF3
HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4
transcription factor 7-like 2 (T-cell specific HMG-box)
TCF4
HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0
pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1)
HUGO:PCBD2 HGNC:24474 ENTREZ:84105 UNIPROT:Q9H0N5 GENECARDS:PCBD2 KEGG:84105 WIKI:PCBD2
HNF1 homeobox A
MODY3 TCF1 "transcription factor 1 hepatic; LF-B1 hepatic nuclear factor (HNF1) albumin proximal factor"
HUGO:HNF1A HGNC:11621 ENTREZ:6927 UNIPROT:P20823 GENECARDS:HNF1A REACTOME:403244 KEGG:6927 ATLASONC:GC_HNF1A WIKI:HNF1A
HNF1 homeobox B
TCF2 "transcription factor 2 hepatic; LF-B3; variant hepatic nuclear factor"
HUGO:HNF1B HGNC:11630 ENTREZ:6928 UNIPROT:P35680 GENECARDS:HNF1B REACTOME:403844 KEGG:6928 ATLASONC:GC_HNF1B WIKI:HNF1B
transcription factor 3
HUGO:TCF3 HGNC:11633 ENTREZ:6929 UNIPROT:P15923 GENECARDS:TCF3 REACTOME:65901 KEGG:6929 ATLASONC:E2A WIKI:TCF3
transcription factor 4
HUGO:TCF4 HGNC:11634 ENTREZ:6925 UNIPROT:P15884 GENECARDS:TCF4 REACTOME:57613 KEGG:6925 ATLASONC:GC_TCF4 WIKI:TCF4
CCAAT/enhancer binding protein (C/EBP) beta
TCF5
HUGO:CEBPB HGNC:1834 ENTREZ:1051 UNIPROT:P17676 GENECARDS:CEBPB REACTOME:51866 KEGG:1051 ATLASONC:GC_CEBPB WIKI:CEBPB
transcription factor-like 5 (basic helix-loop-helix)
HUGO:TCFL5 HGNC:11646 ENTREZ:10732 UNIPROT:Q9UL49 GENECARDS:TCFL5 KEGG:10732 WIKI:TCFL5
info transcription factor A mitochondrial
HUGO:TFAM HGNC:11741 ENTREZ:7019 UNIPROT:Q00059 GENECARDS:TFAM REACTOME:65899 KEGG:7019 ATLASONC:GC_TFAM WIKI:TFAM
HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 GENECARDS:TCF7 KEGG:6932 ATLASONC:GC_TCF7 WIKI:TCF7
HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 GENECARDS:TCF7L1 KEGG:83439 ATLASONC:GC_TCF7L1 WIKI:TCF7L1
HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 GENECARDS:TCF7L2 REACTOME:65596 KEGG:6934 ATLASONC:GC_TCF7L2 WIKI:TCF7L2
zinc finger E-box binding homeobox 1
TCF8
HUGO:ZEB1 HGNC:11642 ENTREZ:6935 UNIPROT:P37275 GENECARDS:ZEB1 KEGG:6935 ATLASONC:GC_ZEB1 WIKI:ZEB1
GC-rich sequence DNA-binding factor 2
PREVIOUS SYMBOLS/ C2orf3 "chromosome 2 open reading frame 3" TCF9 "transcription factor 9 (binds GC-rich sequences)"
HUGO:GCFC2 HGNC:1317 ENTREZ:6936 UNIPROT:P16383 GENECARDS:GCFC2 KEGG:6936 WIKI:GCFC2
HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 GENECARDS:LEF1 KEGG:51176 ATLASONC:GC_LEF1 WIKI:LEF1
nuclear factor (erythroid-derived 2)-like 1
TCF11
HUGO:NFE2L1 HGNC:7781 ENTREZ:4779 UNIPROT:Q14494 GENECARDS:NFE2L1 KEGG:4779 ATLASONC:GC_NFE2L1 WIKI:NFE2L1
transcription factor 12
HUGO:TCF12 HGNC:11623 ENTREZ:6938 UNIPROT:Q99081 GENECARDS:TCF12 REACTOME:56728 KEGG:6938 ATLASONC:TCF12ID406 WIKI:TCF12
TEA domain family member 1 (SV40 transcriptional enhancer factor)
AA "atrophia areata peripapillary chorioretinal degeneration" TCF13
HUGO:TEAD1 HGNC:11714 ENTREZ:7003 UNIPROT:P28347 GENECARDS:TEAD1 REACTOME:65831 KEGG:7003 ATLASONC:GC_TEAD1 WIKI:TEAD1
TEA domain family member 4
TCF13L1
HUGO:TEAD4 HGNC:11717 ENTREZ:7004 UNIPROT:Q15561 GENECARDS:TEAD4 REACTOME:65837 KEGG:7004 WIKI:TEAD4
hepatocyte nuclear factor 4 alpha
MODY MODY1 TCF14
HUGO:HNF4A HGNC:5024 ENTREZ:3172 UNIPROT:P41235 GENECARDS:HNF4A REACTOME:211473 KEGG:3172 ATLASONC:GC_HNF4A WIKI:HNF4A
transcription factor 15 (basic helix-loop-helix)
HUGO:TCF15 HGNC:11627 ENTREZ:6939 UNIPROT:Q12870 GENECARDS:TCF15 KEGG:6939 ATLASONC:GC_TCF15 WIKI:TCF15
conserved helix-loop-helix ubiquitous kinase
TCF16
HUGO:CHUK HGNC:1974 ENTREZ:1147 UNIPROT:O15111 GENECARDS:CHUK REACTOME:57214 KEGG:1147 ATLASONC:GC_CHUK WIKI:CHUK
zinc finger protein 354A
TCF17
HUGO:ZNF354A HGNC:11628 ENTREZ:6940 UNIPROT:O60765 GENECARDS:ZNF354A REACTOME:65741 KEGG:6940 WIKI:ZNF354A
transcription factor 19
HUGO:TCF19 HGNC:11629 ENTREZ:6941 UNIPROT:Q9Y242 GENECARDS:TCF19 KEGG:6941 WIKI:TCF19
transcription factor 20
HUGO:TCF20 HGNC:11631 ENTREZ:6942 UNIPROT:Q9UGU0 GENECARDS:TCF20 KEGG:6942 WIKI:TCF20
transcription factor 21
HUGO:TCF21 HGNC:11632 ENTREZ:6943 UNIPROT:O43680 GENECARDS:TCF21 KEGG:6943 ATLASONC:GC_TCF21 WIKI:TCF21
transcription factor 23
HUGO:TCF23 HGNC:18602 ENTREZ:150921 UNIPROT:Q7RTU1 GENECARDS:TCF23 KEGG:150921 WIKI:TCF23
transcription factor 24
HUGO:TCF24 HGNC:32275 ENTREZ:100129654 UNIPROT:Q7RTU0 GENECARDS:TCF24 KEGG:100129654 WIKI:TCF24
transcription factor 25
HUGO:TCF25 HGNC:29181 ENTREZ:22980 UNIPROT:Q9BQ70 GENECARDS:TCF25 KEGG:22980 ATLASONC:GC_TCF25 WIKI:TCF25
Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / MAPK
Survival / HEDGEHOG
Survival / WNT_CANONICAL
References
PMID:19623618
PMID:19619488
HNF1 homeobox
Phosphorylation sites specific for HIPK2 not known
PMID:21285352
References
su_mpk1_mpk1_re107( Survival ):
In the presence of wnt signals (+wnt) the cytosolic amount of b-catenin increases and thus translocates to the nucleus where it associates with transcription factors of the TCF/ LEF family. Due to its transactivating ability the b-catenin-transcription-factor-co mplex binds to DNA and activates wnt target genes.
http://www.gene-regulation.com/info/b-catenin.html
Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / WNT_CANONICAL
References
TCF family: tcf-1 lef-1 tcf-3 tcf-4
PMID:11266540
TCF3 is repressor while others are activators of transcription
PMID:21285352
su_wca1_s_wca3_re26:( Survival ) PMID:14960582
su_wca1_s_wca3_re103:( Survival ) PMID:15747065
su_wca1_s_wca3_re127:( Survival ) PMID:19901072 PMID:19751731
su_wca1_s_wca3_re144( Survival ):
This complex does not contain HDAC but do contain LEF1
PMID:17666529
su_wca1_s_wca3_re147( Survival ):
Phosphorylated TCF/LEF transcription factor dissociates and is replaced by another unphosphorylated one. For example TCF3 (repressor) is phosphorylated by HIPK2 and will dissociate from the complex and is replaced by TCF1.
References
NLK also phosphorylates TCF4@T178 and T189
PMID:12556497
s_wca3_re26:( Survival ) PMID:14960582
s_wca3_re32:( Survival ) PMID:16714285
References
s_wca3_re32:( Survival ) PMID:16714285
References
s_wca3_re103:( Survival ) PMID:15747065
References
s_wca3_re147( Survival ):
Phosphorylated TCF/LEF transcription factor dissociates and is replaced by another unphosphorylated one. For example TCF3 (repressor) is phosphorylated by HIPK2 and will dissociate from the complex and is replaced by TCF1.
PMID:21285352
+ LEF_TCF*@Nucleus → su_mpk1_mpk1_s1019
+ _beta_-Catenin*@Nucleus + gpromoter_region@Nucleus → LEF_TCF*:promoter_region@Nucleus
→ LEF_TCF*|S40_pho@Nucleus
+ BCL9:DVL*:JUN|pho|pho:LEF_TCF*:PYGO*:WRE*:_beta_-Catenin*|K345_ace|ace@Nucleus → APC|T1487_pho:BCL9:CTBP*|hm2:DVL*:HDAC1_2*:JUN|pho|pho:LEF_TCF*:PYGO*:WRE*:_beta_-Catenin*|K345_ace|ace@Nucleus
→ APC|T1487_pho:_beta_-Catenin*|K345_ace|ace@Nucleus + su_wca1_s_wca3_s405 + CTBP*:HDAC1_2*:LEF_TCF*:WRE*@Nucleus + DVL*:JUN|pho|pho@Nucleus
+ TLE*@Nucleus → CTBP*@Nucleus + HDAC1_2*:LEF_TCF*:TLE*:WRE*@Nucleus
+ BCL9:CBP*|S92_pho:DVL*:JUN|pho|pho:PYGO*:_beta_-Catenin*|ace|ace@Nucleus → BCL9:CBP*|S92_pho:DVL*:JUN|pho|pho:LEF_TCF*:PYGO*:WRE*:_beta_-Catenin*|K345_emp|ace|ace@Nucleus + HDAC1_2*:TLE*|ubi@Nucleus
+ HDAC1_2*:LEF_TCF*:TLE*|ubi:WRE*@Nucleus → BCL9:KLF8|K67_ace|K93_ace|K95_ace:LEF_TCF*:PYGO*:WRE*:_beta_-Catenin*|K345_ace|ace@Nucleus + HDAC1_2*:TLE*|ubi@Nucleus
+ BCL9:PYGO*:_beta_-Catenin*|ace@Nucleus + LEF_TCF*@Nucleus + CTBP*@Nucleus + gWRE*@Nucleus → BCL9:CTBP*:LEF_TCF*:PYGO*:WRE*:_beta_-Catenin*|ace@Nucleus
+ HIPK2@Nucleus + CTBP*@Nucleus + LEF_TCF*@Nucleus → CTBP*:HIPK2:LEF_TCF*@Nucleus
→ HDAC1_2*:LEF_TCF*|pho:TLE*:WRE*@Nucleus
+ LEF_TCF*@Nucleus → HDAC1_2*:LEF_TCF*:TLE*:WRE*@Nucleus + LEF_TCF*|pho@Nucleus
→ LEF_TCF*|S166_pho|T155_pho@Nucleus
→ LEF_TCF*|S166_pho|T155_pho|ubi@Nucleus
→ degraded
+ HDAC1_2*@Nucleus + TLE*@Nucleus + gWRE*@Nucleus → HDAC1_2*:LEF_TCF*:TLE*:WRE*@Nucleus
→ HDAC1_2*:LEF_TCF*:TLE*|ubi:WRE*@Nucleus
+ BCL9:DVL*:JUN|pho|pho:PYGO*:_beta_-Catenin*|K345_ace|ace@Nucleus → BCL9:DVL*:JUN|pho|pho:LEF_TCF*:PYGO*:WRE*:_beta_-Catenin*|K345_ace|ace@Nucleus + HDAC1_2*:TLE*|ubi@Nucleus
→ rGLI3@Nucleus
→ rCyclinD*@Nucleus
→ rAXIN1@Nucleus
→ rMMP9@Nucleus
→ rRNA@Nucleus
→ rTCF4@Nucleus
→ rRAD6B*@Nucleus
→ rBCL9@Nucleus
→ arMIR372@Nucleus
→ arMIR373@Nucleus
→ rIRS2@Nucleus
→ rCRIPTO-1*@Nucleus
→ rMYC@Nucleus
→ rRNA@Nucleus