Protein CBP* map

Identifiers
CREB binding protein, CBP
HUGO:CREBBP, HGNC:2348, ENTREZ:1387, UNIPROT:Q92793
HUGO:CREBBP
CREB binding protein
HUGO:CREBBP HGNC:2348 ENTREZ:1387 UNIPROT:Q92793 GENECARDS:CREBBP REACTOME:51510 KEGG:1387 ATLASONC:CBPID42 WIKI:CREBBP
cAMP responsive element binding protein 3
HUGO:CREB3 HGNC:2347 ENTREZ:10488 UNIPROT:O43889 GENECARDS:CREB3 KEGG:10488 ATLASONC:GC_CREB3 WIKI:CREB3
cAMP responsive element binding protein 5
HUGO:CREB5 HGNC:16844 ENTREZ:9586 UNIPROT:Q02930 GENECARDS:CREB5 KEGG:9586 WIKI:CREB5
CBP KAT3A RTS

Maps_Modules
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
 Cell Cycle DNA Repair  map  / G2_M_CHECKPOINT  map
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS  map
 Innate Immunity  map  / IMMUNOSTIMULATORY_CORE_PATHWAYS  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / HEDGEHOG  map
 Survival  map  / PI3K_AKT_MTOR  map
 Survival  map  / WNT_CANONICAL  map

References
PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786, PMID:20144767
PMID:19879327
STAT1 is acetylated by CBP at the lysine residues K410 and K413.
PMID:16007092
GSK3B induces RELA (p65) interaction with CBP and activates downstream NF-kB signaling end expression of proinflammatory cytokines.
PMID:12417340
IRF-8/ICSBP and IRF-1 cooperatively stimulate mouse IL-12 p40 promoter activity in macrophages.
IRF-1 can be acetylated by p300. p300 is recruited to the IL-12p40 promoter depending on both ICSBP and IRF-1
and acts as coactivator in macrophages.
PMID:17565603
PMID:15337521
CREB binding protein

CBP*@Nucleus

References
ce_re34:( Cell Cycle DNA Repair  map ) PMID:19788416
ce_re404( Cell Cycle DNA Repair  map ):
Acetylation of c-Myc keeps it inactive and prevents G1/S propagation
PMID:15522869

CBP*@INNATE_IMMUNE_CELL_Cytosol

References
in_re708( Innate Immunity  map ):
PMID:17689680
STAT1 acetilation inhibits its activity in macrophages.
PMID:19879327
Probably STAT1 is acetylated by CBP at the lysine residues K410 and K413.

CBP*|​S92_pho@Nucleus

References
s_wca3_re8( Survival  map ):
MEK/ERK cascade activation is the upstream signal required for phosphorylation.
PMID:21751375
s_wca3_re11( Survival  map ):
CBP acetylates beta-catenin
PMID:11973335

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. CBP*@INNATE_IMMUNE_CELL_Cytosol map
In compartment: Nucleus
  1. CBP*@Nucleus map
  2. CBP*|​S92_pho@Nucleus map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. CBP*:​RELA@INNATE_IMMUNE_CELL_Cytosol map
  2. CBP*:​CREB1|​pho@INNATE_IMMUNE_CELL_Cytosol map
In compartment: Nucleus
  1. CBP*:​promoter_region@Nucleus map
  2. BCL9:​CBP*|​S92_pho:​PYGO*:​_beta_-Catenin*|​ace|​ace@Nucleus map
  3. BCL9:​CBP*|​S92_pho:​DVL*:​JUN|​pho|​pho:​PYGO*:​_beta_-Catenin*|​ace|​ace@Nucleus map
  4. BCL9:​CBP*|​S92_pho:​DVL*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_emp|​ace|​ace@Nucleus map
  5. CBP*:​CDK8:​Core_promoter*:​CyclinC*:​GLI3-190*:​MED12:​MED13:​Mediator*:​promoter_region@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. CBP*@INNATE_IMMUNE_CELL_Cytosol map + RELA@INNATE_IMMUNE_CELL_Cytosol map → map CBP*:​RELA@INNATE_IMMUNE_CELL_Cytosol map
  2. CREB1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map + CBP*@INNATE_IMMUNE_CELL_Cytosol map → map CBP*:​CREB1|​pho@INNATE_IMMUNE_CELL_Cytosol map
  3. CREB*|​pho@Nucleus map + gpromoter_region@Nucleus map + CBP*@Nucleus map → map CBP*:​promoter_region@Nucleus map
  4. CDK8:​Core_promoter*:​CyclinC*:​MED12:​MED13:​Mediator*@Nucleus map + CBP*@Nucleus map + gpromoter_region@Nucleus map + GLI3-190*|​unk|​active@Nucleus map → map CBP*:​CDK8:​Core_promoter*:​CyclinC*:​GLI3-190*:​MED12:​MED13:​Mediator*:​promoter_region@Nucleus map
  5. BCL9:​PYGO*:​_beta_-Catenin*|​ace@Nucleus map + CBP*|​S92_pho@Nucleus map → map BCL9:​CBP*|​S92_pho:​PYGO*:​_beta_-Catenin*|​ace|​ace@Nucleus map
  6. HDAC1_2*:​LEF_TCF*:​TLE*|​ubi:​WRE*@Nucleus map + BCL9:​CBP*|​S92_pho:​DVL*:​JUN|​pho|​pho:​PYGO*:​_beta_-Catenin*|​ace|​ace@Nucleus map → map BCL9:​CBP*|​S92_pho:​DVL*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_emp|​ace|​ace@Nucleus map + HDAC1_2*:​TLE*|​ubi@Nucleus map
  7. DVL*:​JUN|​pho|​pho@Nucleus map + BCL9:​CBP*|​S92_pho:​PYGO*:​_beta_-Catenin*|​ace|​ace@Nucleus map → map BCL9:​CBP*|​S92_pho:​DVL*:​JUN|​pho|​pho:​PYGO*:​_beta_-Catenin*|​ace|​ace@Nucleus map
  8. CBP*@Nucleus map → map CBP*|​S92_pho@Nucleus map
As Catalyser:
  1. p53*@Nucleus map → map p53*|​pho|​ace|​active@Nucleus map
  2. MYC@Nucleus map → map MYC|​ace@Nucleus map
  3. NFkB*@INNATE_IMMUNE_CELL_Cytosol map → map NFkB*@INNATE_IMMUNE_CELL_Cytosol map
  4. CBP*@INNATE_IMMUNE_CELL_Cytosol map + RELA@INNATE_IMMUNE_CELL_Cytosol map → map CBP*:​RELA@INNATE_IMMUNE_CELL_Cytosol map
  5. STAT1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map → map STAT1|​pho|​ace@INNATE_IMMUNE_CELL_Cytosol map
  6. IRF1@INNATE_IMMUNE_CELL_Cytosol map → map IRF1|​ace@INNATE_IMMUNE_CELL_Cytosol map
  7. gBCL2@Nucleus map → map rBCL2@Nucleus map
  8. gMCL1@Nucleus map → map rMCL1@Nucleus map
  9. gGenes under control of _br_CBP-mediated transcription*@Nucleus map → map rRNA@Nucleus map
  10. gMIR372@Nucleus map → map arMIR372@Nucleus map
  11. gMIR373@Nucleus map → map arMIR373@Nucleus map
  12. gIRS2@Nucleus map → map rIRS2@Nucleus map