Reaction state_transition em_re1454 map

Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*:​p120*@Cytosol map → E-Cadherin*@Clathrin coated vesicle map

Reaction regulators:
Boolean_logic_gate_and
  1. em_s2322 and em_s2321
Catalysis
  1. FGFR family*@Cytosol map
  2. Clathrin dependent endosomal pathway@Clathrin coated vesicle map
  3. em_s2321
  4. em_s2322


References
PMID??:10402472
We conclude that a pool of surface E-cadherin is constantly trafficked through an endocytic, recycling pathway and that this may provide a mechanism for regulating the availability of E-cadherin for junction formation in development, tissue remodeling, and tumorigenesis.
PMID:22674073
Clathrin-mediated endocytosis appears to be responsible for two types of growth factor-induced cadherin internalization, FGF-mediated internalization of E-cadherin () and VEGF-mediated internalization of VE-cadherin.