Protein NICD* map

Identifiers
Notch homolog 1
NOTCH intracellular domains NICD
HUGO:NOTCH1, HGNC:7881, ENTREZ:4851, UNIPROT:P46531, GENECARDS:GC09M139388
notch 1
HUGO:NOTCH1 HGNC:7881 ENTREZ:4851 UNIPROT:P46531 GENECARDS:NOTCH1 REACTOME:60520 KEGG:4851 ATLASONC:NOTCH1ID30ch9q34 WIKI:NOTCH1
notch 2
HUGO:NOTCH2 HGNC:7882 ENTREZ:4853 UNIPROT:Q04721 GENECARDS:NOTCH2 REACTOME:60522 KEGG:4853 ATLASONC:NOTCH2ID41556ch1p12 WIKI:NOTCH2
notch 3
HUGO:NOTCH3 HGNC:7883 ENTREZ:4854 UNIPROT:Q9UM47 GENECARDS:NOTCH3 REACTOME:60524 KEGG:4854 ATLASONC:NOTCH3ID41557ch19p13 WIKI:NOTCH3
notch 4
HUGO:NOTCH4 HGNC:7884 ENTREZ:4855 UNIPROT:Q99466 GENECARDS:NOTCH4 REACTOME:60526 KEGG:4855 ATLASONC:GC_NOTCH4 WIKI:NOTCH4

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / LYSOSOME_ENDOSOME  map
 EMT Senescence  map  / SENESCENCE  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / WNT_CANONICAL  map

References
PMID:21828089
Phosphorylation of NICD by GSK3B inhibits Ntch1/ICD-mediated induction of genes such as Hes1 but stabilizes Notch1/ICD.

NICD*@Cytosol

References
em_emtc_emtc_re1322( EMT Senescence  map ):
TGFbeta activates Notch
PMID:22363130
PMID:22330899

NICD*@Nucleus

References
em_emtc_emtc_re1330:( EMT Senescence  map ) PMID:18049480
em_emtc_emtc_re1347( EMT Senescence  map ):
PMID:21828089
Phosphorylation of NICD by GSK3B inhibits Ntch1/ICD-mediated induction of genes such as Hes1 but stabilizes Notch1/ICD.

NICD*|​pho@Nucleus

References
em_emtc_emtc_re1347( EMT Senescence  map ):
PMID:21828089
Phosphorylation of NICD by GSK3B inhibits Ntch1/ICD-mediated induction of genes such as Hes1 but stabilizes Notch1/ICD.

Modifications:
In compartment: Cytosol
  1. NICD*@Cytosol map
  2. NICD*|​ubi@Cytosol map
In compartment: Nucleus
  1. NICD*@Nucleus map
  2. NICD*|​pho@Nucleus map
  3. NICD*|​ubi@Nucleus map
Participates in complexes:
In compartment: Nucleus
  1. NICD*:​p53*@Nucleus map
  2. CBF1*:​NICD*@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. JAG1|​ubi:​NOTCH1@Neighbouring Cell map → map NICD*@Cytosol map
  2. NICD*@Cytosol map → map NICD*|​ubi@Cytosol map
  3. DLL1:​NOTCH1@Neighbouring Cell map → map NICD*@Cytosol map
  4. p53*@Nucleus map + NICD*@Nucleus map → map NICD*:​p53*@Nucleus map
  5. NICD*@Cytosol map → map NICD*@Nucleus map
  6. NICD*@Nucleus map → map NICD*|​pho@Nucleus map
  7. NICD*@Nucleus map → map NICD*|​ubi@Nucleus map
  8. NICD*|​ubi@Nucleus map → map degraded
  9. NICD*@Nucleus map + CBF1*@Nucleus map → map CBF1*:​NICD*@Nucleus map
  10. NICD*@Nucleus map → map Notch pathway@Nucleus map
  11. _beta_-Catenin*@Nucleus map + NICD*@Nucleus map → map su_wca1_s_wca3_s263
As Catalyser:
  1. gHEY1@Nucleus map → map rHEY1@Nucleus map
  2. gHEY2@Nucleus map → map rHEY2@Nucleus map