Complex E-Cadherin*:ITGA3:TGFB1:TGFBR*:_beta_-Catenin*:p120*
Complex composition:
- ITGA3
- p120*
- TGFB1
- TGFBR*
- _beta_-Catenin*
- E-Cadherin*
E-Cadherin*:ITGA3:TGFB1:TGFBR*:_beta_-Catenin*|Y654_pho|pho:p120*@Endosome
Identifiers
NAME:E-Cadherin*:ITGA3:TGFB1:TGFBR*:_beta_-Catenin*:p120*
Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
Survival
/ WNT_CANONICAL
References
s_wca2_re45( Survival
):
Src phosphorylates Y654 residue on b-catenin
PMID:16099633
s_wca2_re46:( Survival
) PMID:22203675
E-Cadherin*|S840_pho|S853_pho|S855_pho|S849_pho:ITGA3:TGFB1:TGFBR*:_beta_-Catenin*|pho:p120*@Cytoplasm
Identifiers
NAME:E-Cadherin*:ITGA3:TGFB1:TGFBR*:_beta_-Catenin*:p120*
Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
Survival
/ WNT_CANONICAL
References
s_wca2_re37:( Survival
) PMID:19171760
E-Cadherin*:ITGA3:TGFB1:TGFBR*:_beta_-Catenin*|pho:p120*@Endosome
Identifiers
NAME:E-Cadherin*:ITGA3:TGFB1:TGFBR*:_beta_-Catenin*:p120*
Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
Survival
/ WNT_CANONICAL
References
s_wca2_re38:( Survival
) PMID:19171760
s_wca2_re39( Survival
):
Integrin alphaIII beta1 can activate Src
PMID:22203675
Other integrin family member activates as well Src
PMID:19734908
s_wca2_re45( Survival
):
Src phosphorylates Y654 residue on b-catenin
PMID:16099633
Modifications:
Participates in complexes:
In compartment: Cytoplasm
- E-Cadherin*|S840_pho|S853_pho|S855_pho|S849_pho:ITGA3:TGFB1:TGFBR*:_beta_-Catenin*|pho:p120*@Cytoplasm
In compartment: Endosome
- E-Cadherin*:ITGA3:TGFB1:TGFBR*:_beta_-Catenin*|pho:p120*@Endosome
- E-Cadherin*:ITGA3:TGFB1:TGFBR*:_beta_-Catenin*|Y654_pho|pho:p120*@Endosome
Participates in reactions:
As Reactant or Product:- Cytoskeleton:E-Cadherin*|S840_pho|S853_pho|S855_pho|S849_pho:ECM or cell-cell contact:ITGA3:_alpha_-Catenin*:_beta_-Catenin*|pho:p120*@Cytoplasm
+ TGFB1:TGFBR*@Cytoplasm
→
E-Cadherin*|S840_pho|S853_pho|S855_pho|S849_pho:ITGA3:TGFB1:TGFBR*:_beta_-Catenin*|pho:p120*@Cytoplasm
+ ECM or cell-cell contact@default
- E-Cadherin*|S840_pho|S853_pho|S855_pho|S849_pho:ITGA3:TGFB1:TGFBR*:_beta_-Catenin*|pho:p120*@Cytoplasm
→
E-Cadherin*:ITGA3:TGFB1:TGFBR*:_beta_-Catenin*|pho:p120*@Endosome
- E-Cadherin*:ITGA3:TGFB1:TGFBR*:_beta_-Catenin*|pho:p120*@Endosome
→
E-Cadherin*:ITGA3:TGFB1:TGFBR*:_beta_-Catenin*|Y654_pho|pho:p120*@Endosome
- E-Cadherin*:ITGA3:TGFB1:TGFBR*:_beta_-Catenin*|Y654_pho|pho:p120*@Endosome
→
E-Cadherin*:ITGA3:TGFB1:TGFBR*:p120*@Endosome
+ _beta_-Catenin*|Y654_pho@Cytoplasm
As Catalyser:- SRC@Cytoplasm
→
SRC@Cytoplasm