Cadherin*

Protein Cadherin*

Identifiers
cadherin 1, type 1, E-cadherin (epithelial)
HUGO:CDH1, HGNC:1748, ENTREZ:999, GENECARDS:GC16P068771, UNIPROT:P12830
cadherin 2, type 1, N-cadherin (neuronal)
HUGO:CDH2, HGNC:1759, ENTREZ:1000, UNIPROT:P19022, GENECARDS:GC18M025465????
cadherin 3, type 1, P-cadherin (placental)
HUGO:CDH3, HGNC:1762, ENTREZ:1001, UNIPROT:P22223, GENECARDS:GC16P068679??????
cadherin 4, type 1, R-cadherin (retinal)
HUGO:CDH4, HGNC:1763, ENTREZ:1002, UNIPROT:P55283, GENECARDS:GC20P059827??
cadherin 5, type 2 (vascular endothelium)
HUGO:CDH5, HGNC:1764, ENTREZ:1003, UNIPROT:P33151, GENECARDS:GC16P066400????

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / CELL_CELL_ADHESIONS
EMT Senescence / ADHERENS_JUNCTIONS

Cadherin*@Cytosol

References
em_re1497( EMT Senescence ):
PMID:22674073
E-cadherin does not travel directly from the Golgi complex to the cell surface, but transits first through Rab11-positive recycling endosomes. Rab11 is involved in E-cadherin localization to the surface of the cell .
In addition to acting as way stations for newly synthesized cadherin on its way to the plasma membrane, Rab11-positive recycling endosomes can also sort internalized cadherin for recycling back to the cell surface.
Desclozeaux and colleagues also found that cadherin recycling is necessary for maintaining adherens junctions.
em_emtc_emtc_re1022( EMT Senescence ):
PMID:15609097
CTNNB1 (beta-catenin) binds with high affinity to the distal Cadherin cytoplasmic tail.
Cadherin recruits CTNNA1 (alpha-catenin) to the complex.
CTNNA1 (alpha-catenin) binds to Actin filaments directly
CTNNA1 (alpha-catenin) and can also associate with other actin-binding proteins (MLLT4 or Formin)
CTNND1 (delta-catenin or p120) binds directly to Cadherin independently of the other catenins.
Catenins/Cadherin complex can further interact with a range of singaling molecules which participate in either cellular signaling or control of cytoskeletal dynamics.
Stability of Cadherin/Catenins complex and thereby the integrity of adherens junctions is controlled by phosphorylation/dephosphorylation.

Modifications:
In compartment: Cytosol

Cadherin*@Cytosol

Participates in complexes:
In compartment: Cytosol

Participates in reactions:
As Reactant or Product:

As Catalyser: