Gene MIR183 map

Identifiers
microRNA 183
HUGO:MIR183, HGNC:31554, ENTREZ:406959, GENECARDS:GC07M129416
HUGO:MIR183

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
HMC:TUMOR_PROMOTING_INFLAMMATION
 Innate Immunity  map  / MIRNA_TF_IMMUNOSUPPRESSIVE  map

References
 NATURAL_KILLER  map
CASCADE:TGFB
PMID:24586048
Suppression of NK cells is a result of TGF-?? induction of microRNA (miR)-183, which binds and represses DNAX activating protein 12 kDa (DAP12), a signal adaptor for lytic function in NK cells.

gMIR183@Nucleus

References
em_emtc_emtc_re1136( EMT Senescence  map ):
PMID:20706219
Feedback loop: ZEB1 inhibits expression of MIR203 and MIR183
PMID:19935649
ZEB1 directly controls transcription of the miR-203 and miR-183 and miR-200 family genes
PMID:24335145
??-Catenin/TCF/LEF-1 binds to the promoter of miR-183-96-182 cluster gene and thereby activates the transcription of the cluster.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. gMIR183@INNATE_IMMUNE_CELL_Cytosol map
In compartment: Nucleus
  1. gMIR183@Nucleus map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gMIR183@Nucleus map → map arMIR183@Nucleus map
    2. gMIR183@INNATE_IMMUNE_CELL_Cytosol map → map arMIR183@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser: