KLF8

Protein KLF8

Identifiers
Kruppel-like factor 8
HUGO:KLF8, HGNC:6351, ENTREZ:11279, UNIPROT:O95600
HUGO:KLF8 HGNC:6351 ENTREZ:11279 UNIPROT:O95600 GENECARDS:KLF8 KEGG:11279 ATLASONC:GC_KLF8 WIKI:KLF8

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / RCD_GENES
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / WNT_CANONICAL

References
PMID:17671186
KLF8 directly bound to the promotor of Snail and repressed Snail expression

KLF8@Nucleus

References
em_emtc_emtc_re1( EMT Senescence ):
PMID:20731704
PMID:21317430
In NMuMG cells treated with TGFB1 Snail1 RNA and protein are induced 1 h after addition of the cytokine preceding Zeb1 up-regulation that requires 6???8 h.
Zeb1 gene expression is caused by increased RNA levels but also by enhanced protein stability and is markedly dependent on Snail1 because depletion of this protein prevents Zeb1 protein and RNA up-regulation
PMID:22406545
TGFB can activate both SNAI1 and SNAI2 and thus promote EMT via both SMAD-dependent and -independent pathways
PMID:16617148
Negative feedback by SNAI1 itself
PMID:17671186
KLF8 directly bound to the promotor of Snail and repressed Snail expression
PMID:17563753
Snail promoter is regulated positively by NFkB_p65
PMID:16831886
PMID:18832382
HMGA2 directly binds to the SNAIL1 promoter and acts as a transcriptional regulator of SNAIL1 expression.
HMGA2 cooperates with SMAD3 and SMAD4 to execute a dramatic super-induction of the SNAIL1 promoter.
Same results were obtained with SNAI2, ZEB1, ZEB2 and TWIST1
HMGA2 cooperates with TGFB1 signaling to represse ID2 transcriptomal expression

Modifications:
In compartment: Nucleus

KLF8@Nucleus

Participates in complexes:
In compartment: Nucleus

Participates in reactions:
As Reactant or Product:

As Catalyser: