Protein HIPK2 map

Identifiers
homeodomain interacting protein kinase 2
HUGO:HIPK2, HGNC:14402, ENTREZ:28996, UNIPROT:Q9H2X6
"homeodomain-interacting protein kinase 2"
HUGO:HIPK2 HGNC:14402 ENTREZ:28996 UNIPROT:Q9H2X6 GENECARDS:HIPK2 KEGG:28996 ATLASONC:HIPK2ID40824ch7q34 WIKI:HIPK2

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / SENESCENCE  map
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
 Cell Cycle DNA Repair  map  / G2_M_CHECKPOINT  map
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / DNA_DAMAGE_RESPONSE  map
 Regulated Cell Death  map  / MOMP_REGULATION  map
 Regulated Cell Death  map  / RCD_GENES  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / WNT_CANONICAL  map
 Survival  map  / WNT_NON_CANONICAL  map

References
PMID:15082531
The activation of MP3K7(TAK1) by TAB1 activates NLK. the TAK1???NLK MAPK pathway regulates Wnt signaling by phosphorylating TCF in mammalian cells.
The TAB1 protein is a specific partner of TAK1 and promotes TAK1 autophosphorylation.
Coexpression of TAK1 and TAB1 in mammalian cells activate HIPK2, that activate NLK. THe coexpression of NLK and HIPK2 induces the degradation of the c-Myb protein.
Degradation of c-Myb protein by Wnt-1 signal via the pathway involving TAK1, HIPK2, and NLK leads to G1 arrest.
PMID:10391247
TAK1 activation stimulates NLK activity and downregulates transcriptional activation mediated by beta-catenin and TCF.
PMID:12851404, PMID:11925430, PMID:19828042, PMID:17349959
HIPK2 is pre-dominantly present in the nucleus
PMID:18974774

HIPK2|​pho|​active@Nucleus

References
ce_re34:( Cell Cycle DNA Repair  map ) PMID:19788416

Modifications:
In compartment: Nucleus
  1. HIPK2@Nucleus map
  2. HIPK2|​pho|​active@Nucleus map
Participates in complexes:
In compartment: Nucleus
  1. AXIN*:​HIPK2@Nucleus map
  2. CTBP*:​HIPK2:​LEF_TCF*@Nucleus map
  3. AXIN*:​HIPK2:​p53*|​S46_pho@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. HIPK2@Nucleus map → map HIPK2|​pho|​active@Nucleus map
  2. HIPK2@Nucleus map → map degraded
  3. HIPK2@Nucleus map → map HIPK2@Nucleus map
  4. HIPK2@Nucleus map → map p53 pathway@Nucleus map
  5. _beta_-Catenin*@Nucleus map + HIPK2@Nucleus map + CTBP*@Nucleus map + LEF_TCF*@Nucleus map → map CTBP*:​HIPK2:​LEF_TCF*@Nucleus map
  6. HIPK2@Nucleus map → map Apoptosis@Nucleus map
  7. HIPK2@Nucleus map → map Metastasis@Nucleus map
  8. AXIN*:​HIPK2:​p53*|​S46_pho@Nucleus map → map Apoptosis@Nucleus map
  9. AXIN*:​HIPK2:​p53*|​S46_pho@Nucleus map → map p53-target genes@Nucleus map
  10. AXIN*@Nucleus map + p53*@Nucleus map + HIPK2@Nucleus map → map AXIN*:​HIPK2@Nucleus map
  11. AXIN*:​HIPK2@Nucleus map → map AXIN*:​HIPK2:​p53*|​S46_pho@Nucleus map
As Catalyser:
  1. p53*@Nucleus map → map p53*|​pho|​ace|​active@Nucleus map
  2. CTBP*@Nucleus map → map CTBP*|​S422_pho@Nucleus map
  3. JNK*@Nucleus map → map JNK*|​pho|​active@Nucleus map
  4. TCF4@Nucleus map → map TCF4|​pho@Nucleus map
  5. NLK@Nucleus map → map NLK@Nucleus map
  6. MYB@Cytosol map → map degraded
  7. p53*@Nucleus map → map p53*|​S15_pho|​active@Nucleus map
  8. CTBP*@Nucleus map → map CTBP*|​S422_pho@Nucleus map
  9. gCyclinD*@Nucleus map → map rCyclinD*@Nucleus map
  10. CTBP*@Nucleus map → map CTBP*|​S422_pho@Nucleus map
  11. HDAC1_2*:​LEF_TCF*:​TLE*:​WRE*@Nucleus map → map HDAC1_2*:​LEF_TCF*|​pho:​TLE*:​WRE*@Nucleus map
  12. _beta_-Catenin*@Nucleus map → map _beta_-Catenin*|​pho|​pho@Nucleus map
  13. NLK|​hm2@Cytoplasm map → map NLK|​T286_pho|​hm2|​active@Cytoplasm map