Reaction transcription em_emtc_emtc_re1123 map

gMYC@Nucleus map → rMYC@Nucleus map

Reaction regulators:
Physical_stimulation
  1. LEF1_TCF3_4*:​_beta_-Catenin*@Nucleus map
  2. STAT3|​pho|​active@Nucleus map


References
PMID:15810077
Beta-catenin up-regulates the expression of cyclinD1, c-myc and MMP-7 in human pancreatic cancer: relationships with carcinogenesis and metastasis.
PMID:22943793
Role of TGFB in regulation of cell cycle:
Physiologically, TGFB is a potent inhibitor of cell cycle.
It induces expression of p15INK4B and represses expression of c-Myc
Low levels of c-Myc allows TGFB to induce p15INK4B and p21CIP1 transcription