Reaction transcription su_wca1_s_wca3_re65 map

gMYC@Nucleus map → rMYC@Nucleus map

Reaction regulators:
Catalysis
  1. BCL9:​PYGO*:​SMAD1|​pho:​TCF4:​_beta_-Catenin*|​K345_ace|​ace@Nucleus map
  2. BCL9:​KLF8|​K67_ace|​K93_ace|​K95_ace:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace@Nucleus map
  3. BCL9:​DVL*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace@Nucleus map
Inhibition
  1. SMAD1|​pho@Nucleus map
  2. CHD3_4*:​GATAD2A_B*:​HDAC1_2*:​MBD2_3*:​MTA1_2_3*:​RBBP4_7*@Nucleus map


Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / WNT_CANONICAL  map

References
PMID:22761862
Smad1 alone inhibits myc expression while b-catenin/TCF4 activates gene expression. Highest gene expression obtained when SMAD1/b-catenin/TCF4 complex is formed
PMID:15576399
Mi-2/NuRD
PMID:22290435