Complex Cadherin*:_alpha_-Catenin*:_beta_-Catenin* map
Complex composition:

  1. _alpha_-Catenin* map
  2. _beta_-Catenin* map
  3. Cadherin* map

Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*@Cytosol

Identifiers
NAME:Cadherin*:_alpha_-Catenin*:_beta_-Catenin*

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CELL_CELL_ADHESIONS  map
 EMT Senescence  map  / ADHERENS_JUNCTIONS  map

References
PMID:15609097
CTNNB1 (beta-catenin) binds with high affinity to the distal Cadherin cytoplasmic tail.
Cadherin recruits CTNNA1 (alpha-catenin) to the complex.
CTNNA1 (alpha-catenin) binds to Actin filaments directly
CTNNA1 (alpha-catenin) and can also associate with other actin-binding proteins (MLLT4 or Formin)
CTNND1 (delta-catenin or p120) binds directly to Cadherin independently of the other catenins.
Catenins/Cadherin complex can further interact with a range of singaling molecules which participate in either cellular signaling or control of cytoskeletal dynamics.
Stability of Cadherin/Catenins complex and thereby the integrity of adherens junctions is controlled by phosphorylation/dephosphorylation.

Modifications:
Participates in complexes:
In compartment: Cytosol
  1. Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. _beta_-Catenin*@Cytosol map + Cadherin*@Cytosol map + _alpha_-Catenin*@Cytosol map → map Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*@Cytosol map
  2. Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*@Cytosol map + Cadherin*:​p120*@Cytosol map + Actin cytoskeletal*@Cytosol map → map Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*:​p120*@Cytosol map
As Catalyser: