Identifiers
HGNC:4566
HUGO:GRB2
growth factor receptor bound protein 2
HUGO:GRB2 hgnc_id:HGNC:4566 HGNC:4566 ENTREZ:2885 UNIPROT:P62993
HUGO:GRB2, HGNC:4566, ENTREZ:2885, UNIPROT:P62993, GENECARDS:GC17M073313
HUGO:GRB2 HGNC:4566 ENTREZ:2885 UNIPROT:P62993
HUGO:GRB2 HGNC:4566 ENTREZ:2885 UNIPROT:P62993 GENECARDS:GRB2 REACTOME:404631 KEGG:2885 ATLASONC:GRB2ID386ch17q25 WIKI:GRB2

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response   / TCR_SIGNALING 
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts   / CORE 
 EMT Senescence   / EMT_REGULATORS 
 Innate Immunity   / IMMUNOSTIMULATORY_CORE_PATHWAYS 
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival   / MAPK 
 Survival   / PI3K_AKT_MTOR 

References
PMID:19449109
PMID:10811803 PMID:12640133 PMID:26552706
CASCADE:FGF
CASCADE:EGFR
GASCADE:IGF1R
PMID:15567848
Canonicaly growth factor pathways activates ERK sigvaling via GRB2/SOS/RAS/RAF/MAPK pathway, probably in fibroblast too.
PMID:11447289
Grb2 forms a complex with tyrosine-phosphorylated Shc in FGF-stimulated fibroblasts in an FRS2??-independent manner
PMID:10567412; PMID:15567848
EGFR activates ERK via GRB2/SOS/RAS/RAF pathway
EGFR induces SHC phosphorylation, directly interacts with GRB2 and induces formation of SHC:GRB2:SOS activated complex.
PMID:12175651; PMID:10086337
Upon IGF-IR autophosphorylation the protein Shc is recruited to the receptor and becomes phosphorylated on tyrosine residues.36 Activated Shc then binds the adaptor Grb2 in an IRS-1-independent manner, leading to activation of the Ras-ERK pathway.36 This pathway of IGF-IR signaling has been most closely associated with cell differentiation and migration, but in some cases also can regulate the machinery of apoptosis, for example, in detachment-induced death, or anoikis, in fibroblasts.
PMID:17673906
SHC1 gene has 3 corresponding protein isoforms: p66, p52 and p46
Upon TGFB stimulation, the activated TGFBR1 recruits and directly phosphorylates SHC1 (p66 or p52) on tyrosine and serine.
TGFB-induced SHC1 phosphorylation induces SHC1 (p66 or p52) association with Grb2 and Sos
GRB2 is an adaptator for Ras
 MACROPHAGE 
 NATURAL_KILLER 
CASCADE:NKG2D
CASCADE:IL4
CASCADE:Fc_gamma_RIII
CASCADE:INTEGRIN_A4B1
CASCADE:INTEGRIN_A5B1
PMID:16887996, PMID:16582911??
Vav1 interacts with DAP10 YxNM motifs through the adaptor protein Grb2 and is required for activation of PI3K-dependent Akt signaling.
binding of DAP10??? ???to either p85??? ???or Grb2??? ???alone is not sufficient to trigger DAP10-mediated cytotoxicity and that both binding sites are necessary for NKG2D-initiated killing.
PMID:10982827
Shc and GRB2 mediate Gab2 tyrosyl phosphorylation. Mutation of the three tyrosyl phosphorylation sites of Shc, which bind Grb2, blocks the ability of the Shc chimera to evoke Gab2 tyrosyl phosphorylation in B cells
PMID:8551221
SHC1 protein is phosphorylated upon CD16 and IL-2R Stimulation in Human NK Cells and interacts with GRB2
Grb2 is an adaptor protein normally present in cytosol. It is recruited to the plasma membrane by activated RTK.
PMID:17496910
PMID:15574420
PMID:11777939

References
su_mpk1_mpk1_re286( Survival  ):
Sos is recruited from the cytosol to the plasma membrane as a result of its constitutive interaction with Grb2. It is in an autoinhibited state.
PMID:17496910
su_mpk1_mpk1_re287( Survival  ):
Grb2 recruits the docking protein Gab1 which is tyrosine phosphorylated by EGFR or FGFR leading to recruitment and activation of the PI3K-Akt cell survival pathway.
PMID:15567848

1. GRB2@Cytoplasm

1. GRB2@Cytosol

1. GRB2@Extracellular Matrix

1. GRB2@INNATE_IMMUNE_CELL_Cytosol

1. GRB2@T_cell

1. GAB1:​GRB2@Cytoplasm
2. GRB2:​SOS*@Cytoplasm
3. GRB2:​SOS*@Cytoplasm
4. GAB1|​pho:​GRB2@Cytoplasm
5. GRB2:​MAP3K1|​pho:​RAS*|​pho:​RTK*:​SOS*@Cytoplasm
6. GRB2:​MAP3K2_3*|​pho:​RAS*|​pho:​RTK*:​SOS*@Cytoplasm
7. GRB2:​MAP3K10_11*|​pho:​RAC1|​pho:​RTK*:​SOS*@Cytoplasm

1. GRB2:​SHC1:​SOS*@Cytosol
2. GRB2:​KDR|​Y1175_pho|​1054_pho:​NCK1:​NRP1:​SHC1:​SHP1*:​SHP2*:​VEGFA:​VEGFB@Cytosol
3. ANGPT1:​ANGPT2:​Dok-R*:​GRB2:​GRB7:​SHC1:​SHP2*:​TEK:​TEK|​pho|​pho|​pho@Cytosol
4. CRK:​CRKL:​FIGF:​FLT4:​FLT4|​Y1063_pho|​Y1337_pho|​Y1230_pho:​GRB2:​NRP2:​SHC1:​VEGFC@Cytosol

1. GAB1:​GF:​GRB2:​PI3,4,5-P3:​RAS*:​RTK*|​pho|​pho|​hm2:​SOS*:​p110*:​p85*@Endosome

1. GRB2:​LAT|​pho@INNATE_IMMUNE_CELL_Cytosol
2. GRB2:​SHC1|​pho@INNATE_IMMUNE_CELL_Cytosol

1. DAP10|​pho:​GRB2:​NKG2D*@INNATE_IMMUNE_CELL_Membrane

1. GRB2:​LAMTOR2:​MEK*:​MP1*:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes
2. GRB2:​LAMTOR2:​MEK*|​pho|​pho:​MP1*:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes
3. ERK*|​pho|​pho:​GRB2:​LAMTOR2:​MEK*|​pho|​pho:​MP1*:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes

1. GAB1|​Y977_pho|​Y989_pho:​GF:​GRB2:​PI3,4,5-P3:​RAS*:​RTK*|​pho|​pho|​hm2:​SOS*:​p110*:​p85*@Lipid Raft

1. GRB2:​RTK*:​SOS*@Plasma Membrane
2. GRB2:​RAC1|​pho:​RTK*:​SOS*@Plasma Membrane
3. GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane
4. BRAF|​pho:​GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane
5. GRB2:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane
6. BRAF|​pho:​GRB2:​KSR1-NTER*:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane
7. BRAF|​pho:​GRB2:​KSR1:​MEK*|​pho|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane
8. BRAF|​pho:​ERK*|​pho|​pho:​GRB2:​KSR1:​MEK*|​pho|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane

1. CD28|​pho:​GRAP2:​GRB2@T_cell
2. GRAP:​GRAP2:​GRB2:​LAT|​pho:​PLCG1@T_cell
3. GRAP:​GRAP2:​GRB2:​LAT|​pho:​PLCG1|​pho@T_cell

1. CD28|​pho|​active@cSMAC + GRB2@T_cell + GRAP2@T_cell → CD28|​pho:​GRAP2:​GRB2@T_cell
2. LAT@T_cell + PLCG1@T_cell + GRB2@T_cell + GRAP2@T_cell + GRAP@T_cell → GRAP:​GRAP2:​GRB2:​LAT|​pho:​PLCG1@T_cell
3. GRAP:​GRAP2:​GRB2:​LAT|​pho:​PLCG1@T_cell → GRAP:​GRAP2:​GRB2:​LAT|​pho:​PLCG1|​pho@T_cell
4. GRB2@T_cell → GRB2@T_cell
5. KDR|​Y1175_emp|​1054_pho:​NRP1:​VEGFA:​VEGFB@Cytosol + GRB2@Extracellular Matrix + SHP1*@Extracellular Matrix + NCK1@Extracellular Matrix + SHC1@Extracellular Matrix + SHP2*@Extracellular Matrix → GRB2:​KDR|​Y1175_pho|​1054_pho:​NCK1:​NRP1:​SHC1:​SHP1*:​SHP2*:​VEGFA:​VEGFB@Cytosol
6. GRB2:​KDR|​Y1175_pho|​1054_pho:​NCK1:​NRP1:​SHC1:​SHP1*:​SHP2*:​VEGFA:​VEGFB@Cytosol → FAK*@Cytosol
7. GRB2:​KDR|​Y1175_pho|​1054_pho:​NCK1:​NRP1:​SHC1:​SHP1*:​SHP2*:​VEGFA:​VEGFB@Cytosol → GRB2:​SHC1:​SOS*@Cytosol
8. GRB2:​KDR|​Y1175_pho|​1054_pho:​NCK1:​NRP1:​SHC1:​SHP1*:​SHP2*:​VEGFA:​VEGFB@Cytosol → PKC activation@Cytosol
9. GRB2:​KDR|​Y1175_pho|​1054_pho:​NCK1:​NRP1:​SHC1:​SHP1*:​SHP2*:​VEGFA:​VEGFB@Cytosol → p38*@Cytosol
10. GRB2@Cytosol + SOS*@Cytosol + SHC1@Cytosol → GRB2:​SHC1:​SOS*@Cytosol
11. ANGPT1:​ANGPT2:​TEK@Cytosol + GRB2@Extracellular Matrix + SHC1@Extracellular Matrix + GRB7@Extracellular Matrix + SHP2*@Extracellular Matrix → ANGPT1:​ANGPT2:​Dok-R*:​GRB2:​GRB7:​SHC1:​SHP2*:​TEK:​TEK|​pho|​pho|​pho@Cytosol
12. GRB2:​KDR|​Y1175_pho|​1054_pho:​NCK1:​NRP1:​SHC1:​SHP1*:​SHP2*:​VEGFA:​VEGFB@Cytosol → PKC activation@Cytosol
13. FIGF:​FLT4:​NRP2:​VEGFC@Cytosol → CRK:​CRKL:​FIGF:​FLT4:​FLT4|​Y1063_pho|​Y1337_pho|​Y1230_pho:​GRB2:​NRP2:​SHC1:​VEGFC@Cytosol
14. CRK:​CRKL:​FIGF:​FLT4:​FLT4|​Y1063_pho|​Y1337_pho|​Y1230_pho:​GRB2:​NRP2:​SHC1:​VEGFC@Cytosol → PKC activation@Cytosol
15. ANGPT1:​ANGPT2:​Dok-R*:​GRB2:​GRB7:​SHC1:​SHP2*:​TEK:​TEK|​pho|​pho|​pho@Cytosol → FAK*@Cytosol
16. GRB2@Cytosol → GRB2@Cytosol
17. SHC1_p66_p52*|​Y_pho|​S_pho|​active@Cytosol + em_s2285 + SOS*@Cytosol + GRB2@Cytosol → EGFR family*|​pho|​hm2:​SHC1_p66_p52*|​Y_pho|​S_pho@Cytosol
18. FRS2|​pho|​active@Cytosol + FGFR2|​hm2|​active@Cytosol + GRB2@Cytosol + SOS*@Cytosol → FGFR family*:​FRS2|​pho@Cytosol
19. GRB2@INNATE_IMMUNE_CELL_Cytosol → GRB2@INNATE_IMMUNE_CELL_Cytosol
20. GRB2@INNATE_IMMUNE_CELL_Cytosol + DAP10:​NKG2D*@INNATE_IMMUNE_CELL_Membrane → DAP10|​pho:​GRB2:​NKG2D*@INNATE_IMMUNE_CELL_Membrane
21. LAT|​pho@INNATE_IMMUNE_CELL_Cytosol + GRB2@INNATE_IMMUNE_CELL_Cytosol → GRB2:​LAT|​pho@INNATE_IMMUNE_CELL_Cytosol
22. GRB2@INNATE_IMMUNE_CELL_Cytosol + SHC1|​pho@INNATE_IMMUNE_CELL_Cytosol → GRB2:​SHC1|​pho@INNATE_IMMUNE_CELL_Cytosol
23. GRB2:​SOS*@Cytoplasm → RAS activation@Cytoplasm
24. p110*:​p85*@Cytoplasm + GRB2:​SOS*@Cytoplasm + PI3,4,5-P3@Lipid Raft + RTK*@Cytoplasm + GF@default + RAS*@Cytoplasm + GAB1|​Y977_pho|​Y989_pho@Cytoplasm → GAB1|​Y977_pho|​Y989_pho:​GF:​GRB2:​PI3,4,5-P3:​RAS*:​RTK*|​pho|​pho|​hm2:​SOS*:​p110*:​p85*@Lipid Raft
25. GAB1:​GF:​GRB2:​PI3,4,5-P3:​RAS*:​RTK*|​pho|​pho|​hm2:​SOS*:​p110*:​p85*@Endosome → Ubiquitination@Cytoplasm
26. GAB1|​Y977_pho|​Y989_pho:​GF:​GRB2:​PI3,4,5-P3:​RAS*:​RTK*|​pho|​pho|​hm2:​SOS*:​p110*:​p85*@Lipid Raft → GAB1:​GF:​GRB2:​PI3,4,5-P3:​RAS*:​RTK*|​pho|​pho|​hm2:​SOS*:​p110*:​p85*@Endosome
27. RAF1@Cytoplasm + GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane → GRB2:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane
28. GRB2:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane → GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane + RAF1|​pho@Mitochondria
29. GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane + BRAF@Cytoplasm → BRAF|​pho:​GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane
30. GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane + MAP3K1@Cytoplasm → GRB2:​MAP3K1|​pho:​RAS*|​pho:​RTK*:​SOS*@Cytoplasm
31. GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane + MAP3K2_3*@Cytoplasm → GRB2:​MAP3K2_3*|​pho:​RAS*|​pho:​RTK*:​SOS*@Cytoplasm
32. GRB2:​RTK*:​SOS*@Plasma Membrane + RAC1@Plasma Membrane → GRB2:​RAC1|​pho:​RTK*:​SOS*@Plasma Membrane
33. BRAF|​pho:​GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane + KSR1:​MEK*@Cytoplasm → BRAF|​pho:​GRB2:​KSR1:​MEK*|​pho|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane
34. GRB2:​RAC1|​pho:​RTK*:​SOS*@Plasma Membrane → RAC1@Plasma Membrane + GRB2:​RTK*:​SOS*@Plasma Membrane
35. GRB2:​RAC1|​pho:​RTK*:​SOS*@Plasma Membrane + MAP3K10_11*@Cytoplasm → GRB2:​MAP3K10_11*|​pho:​RAC1|​pho:​RTK*:​SOS*@Cytoplasm
36. BRAF|​pho:​GRB2:​KSR1:​MEK*|​pho|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane + ERK*@Cytoplasm → BRAF|​pho:​ERK*|​pho|​pho:​GRB2:​KSR1:​MEK*|​pho|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane
37. GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane + LAMTOR2:​MEK*:​MP1*@Late Endosomes → GRB2:​LAMTOR2:​MEK*:​MP1*:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes
38. ERK*|​pho|​pho:​GRB2:​LAMTOR2:​MEK*|​pho|​pho:​MP1*:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes → GRB2:​LAMTOR2:​MEK*:​MP1*:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes + ERK*@Cytoplasm + RAF1@Cytoplasm
39. RAF1@Cytoplasm + GRB2:​LAMTOR2:​MEK*:​MP1*:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes → GRB2:​LAMTOR2:​MEK*|​pho|​pho:​MP1*:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes
40. ERK*@Cytoplasm + GRB2:​LAMTOR2:​MEK*|​pho|​pho:​MP1*:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes → ERK*|​pho|​pho:​GRB2:​LAMTOR2:​MEK*|​pho|​pho:​MP1*:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes
41. GRB2:​SOS*@Cytoplasm + RTK*@Plasma Membrane → GRB2:​RTK*:​SOS*@Plasma Membrane
42. GAB1:​GRB2@Cytoplasm → GAB1|​pho:​GRB2@Cytoplasm
43. GRB2@Cytoplasm + SOS*@Cytoplasm → GRB2:​SOS*@Cytoplasm
44. GRB2@Cytoplasm + GAB1@Cytoplasm → GAB1:​GRB2@Cytoplasm
45. BRAF|​pho:​ERK*|​pho|​pho:​GRB2:​KSR1:​MEK*|​pho|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane → KSR1:​MEK*@Cytoplasm + BRAF|​pho:​GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane + ERK*|​pho|​pho@Cytoplasm
46. BRAF|​pho:​GRB2:​KSR1:​MEK*|​pho|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane → BRAF|​pho:​GRB2:​KSR1-NTER*:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane + KSR1-CTER*:​MEK*@Cytoplasm
47. ERK*|​pho|​pho:​GRB2:​LAMTOR2:​MEK*|​pho|​pho:​MP1*:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes → GRB2:​LAMTOR2:​MEK*|​pho|​pho:​MP1*:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes + ERK*|​pho|​pho@Cytoplasm
48. GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane → RAS*@Plasma Membrane + GRB2:​RTK*:​SOS*@Plasma Membrane
49. BRAF|​pho:​ERK*|​pho|​pho:​GRB2:​KSR1:​MEK*|​pho|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane → ERK*|​pho|​pho:​KSR1:​MEK*|​pho|​pho@Cytoplasm + BRAF|​pho:​GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane
50. RAS*@Plasma Membrane + GRB2:​RTK*:​SOS*@Plasma Membrane → GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane

1. PIP2*@T_cell → IP3@T_cell + DAG@T_cell
2. SOS*@T_cell → SOS*@T_cell
3. LCP2@T_cell → LCP2|​pho@T_cell
4. SYK@Cytosol → SYK|​pho@Cytosol
5. PIK3R1|​pho:​PIK3R2@Cytosol + PIK3CD@Cytosol + GRB7@Cytosol → GRB7:​PIK3CD:​PIK3R1|​pho:​PIK3R2@Cytosol
6. PIK3R1:​PIK3R2@Cytosol → PIK3R1|​pho:​PIK3R2@Cytosol
7. MAP2K4@Cytosol → MAP2K4|​pho@Cytosol
8. PIK3R1:​PIK3R2@Cytosol → PIK3R1|​pho:​PIK3R2@Cytosol
9. CREB*@Cytosol → CREB*|​S133_pho@Cytosol
10. PLCG1@Cytosol → PLCG1|​pho@Cytosol
11. FAK*@Cytosol → FAK*|​pho@Cytosol
12. GDP:​RAS*@Cytosol → GTP:​RAS*@Cytosol
13. GRB2@Cytosol + SOS*@Cytosol + SHC1@Cytosol → GRB2:​SHC1:​SOS*@Cytosol
14. CXCL8@Cytosol → CXCL8@Extracellular Matrix
15. FYN@Cytosol → FYN|​pho@Cytosol
16. GAB1@Cytosol → GAB1|​pho@Cytosol
17. SOS*@Cytosol → SOS*@Cytosol
18. PI3KR(p85)*@INNATE_IMMUNE_CELL_Cytosol → PI3KR(p85)*@INNATE_IMMUNE_CELL_Cytosol
19. VAV1@INNATE_IMMUNE_CELL_Cytosol → VAV1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol
20. LCP2@INNATE_IMMUNE_CELL_Cytosol → LCP2|​pho@INNATE_IMMUNE_CELL_Cytosol
21. PLCG2@INNATE_IMMUNE_CELL_Cytosol → PLCG2|​pho@INNATE_IMMUNE_CELL_Cytosol
22. PLCG1@INNATE_IMMUNE_CELL_Cytosol → PLCG1|​pho@INNATE_IMMUNE_CELL_Cytosol
23. CBL@INNATE_IMMUNE_CELL_Cytosol → CBL|​pho|​active@INNATE_IMMUNE_CELL_Cytosol
24. GAB2@INNATE_IMMUNE_CELL_Cytosol → GAB2|​pho@INNATE_IMMUNE_CELL_Cytosol
25. CD18*@INNATE_IMMUNE_CELL_Membrane + CD11a*@INNATE_IMMUNE_CELL_Membrane → CD11a*:​CD18*@INNATE_IMMUNE_CELL_Membrane
26. ITGB1@INNATE_IMMUNE_CELL_Membrane + ITGA4@INNATE_IMMUNE_CELL_Membrane → (ITGA4:​ITGB1)|​active@INNATE_IMMUNE_CELL_Membrane
27. SOS*@INNATE_IMMUNE_CELL_Cytosol → SOS*@INNATE_IMMUNE_CELL_Cytosol
28. PtdIns(4,5)-P2@Lipid Raft → PI3,4,5-P3@Lipid Raft
29. MAP2K4@Cytoplasm → MAP2K4|​pho|​pho@Cytoplasm
30. MAP2K7@Cytoplasm → MAP2K7|​pho|​pho@Cytoplasm
31. MAP2K6@Cytoplasm → MAP2K6|​pho|​pho@Cytoplasm
32. MEK*@Cytoplasm → MEK*|​pho|​pho@Cytoplasm
33. p110*@Cytoplasm → p110*|​pho@Cytoplasm
34. FRS2@Plasma Membrane → FRS2|​pho@Plasma Membrane
35. IMP*:​KSR1:​MEK*@Cytoplasm → IMP*@Cytoplasm + KSR1:​MEK*@Cytoplasm