Simple molecule IP3 map
IP3@T_cell

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / TCR_SIGNALING  map

References
PMID:25456276

IP3@Cytosol

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / CORE  map

References
PMID:18287025
PLCG is upstream of JNK in the pathway of NKG2D-mediated cytotoxicity
PMID:20189481
PLCG inhibitor completely abrogated synergistic Erk phosphorylation downstream of NKG2D and 2B4.
These data suggest that PLCG, rather than PI3K, is a critical upstream regulator of Erk activation in this pathway.

IP3@INNATE_IMMUNE_CELL_Cytosol

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CORE_PATHWAYS  map

References
PMID:18287025
PLCG is upstream of JNK in the pathway of NKG2D-mediated cytotoxicity
PMID:20189481
PLCG inhibitor completely abrogated synergistic Erk phosphorylation downstream of NKG2D and 2B4.
These data suggest that PLCG, rather than PI3K, is a critical upstream regulator of Erk activation in this pathway.

IP3@Endoplasmic Reticulum

Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / MAPK  map

References
Inositol trisphosphate
su_mpk1_mpk1_re45( Survival  map ):
PLCG acts on PIP2 in the PM to produce DAG and IP3.
PMID:16488589
IP3 diffuses through the cytosol and binds to receptors on the endoplasmic reticulum causing the release of calcium ions (Ca2+) into the cytosol.
http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Second_messengers.html

IP3@Cytoplasm

References
Ca2+/Wnt MODULE
s_wnc1_re26:( Survival  map ) PMID:16054198

Modifications:
In compartment: Cytoplasm
  1. IP3@Cytoplasm map
In compartment: Cytosol
  1. IP3@Cytosol map
In compartment: Endoplasmic Reticulum
  1. IP3@Endoplasmic Reticulum map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. IP3@INNATE_IMMUNE_CELL_Cytosol map
In compartment: T_cell
  1. IP3@T_cell map
Participates in complexes:
In compartment: Endoplasmic Reticulum
  1. IP3:​IP3R*@Endoplasmic Reticulum map
Participates in reactions:
As Reactant or Product:
  1. IP3@T_cell map + IP3R*@T_cell map → map IP3:​IP3R*@Endoplasmic Reticulum map
  2. PIP2*@T_cell map → map IP3@T_cell map + DAG@T_cell map
  3. PI4,5-P2@Cytosol map → map DAG@Cytosol map + IP3@Cytosol map
  4. IP3@INNATE_IMMUNE_CELL_Cytosol map + IP3R*@Endoplasmic Reticulum map → map IP3:​IP3R*@Endoplasmic Reticulum map
  5. PI4,5-P2@INNATE_IMMUNE_CELL_Cytosol map → map DAG@INNATE_IMMUNE_CELL_Cytosol map + IP3@INNATE_IMMUNE_CELL_Cytosol map
  6. IP3@Endoplasmic Reticulum map → map Ca2+@Cytoplasm map
  7. PIP2@Plasma Membrane map → map IP3@Endoplasmic Reticulum map + DAG@Plasma Membrane map
  8. PI4,5-P2@Cytoplasm map → map DAG@Cytoplasm map + IP3@Cytoplasm map
  9. IP3R*@Endoplasmic Reticulum map + IP3@Cytoplasm map → map IP3:​IP3R*@Endoplasmic Reticulum map
As Catalyser:
  1. Ca2+@Endoplasmic Reticulum map → map Ca2+@T_cell map
  2. ERK1/2*@INNATE_IMMUNE_CELL_Cytosol map → map ERK1/2*|​pho@INNATE_IMMUNE_CELL_Cytosol map
  3. Ca2+@Endoplasmic Reticulum map → map Ca2+@INNATE_IMMUNE_CELL_Cytosol map
  4. Ca2+@Endoplasmic Reticulum map → map Ca2+@Cytoplasm map