Simple molecule PtdIns(4,5)-P2 
PtdIns(4,5)-P2@Lipid Raft
Identifiers
1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
CAS:N/A PUBCHEM:7726, CHEBI:18348, KEGGCOMPOUND:C04637
Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / PI3K_AKT_MTOR
References
s_akt1_re4( Survival ):
PMID:12040186
PMID:16288286
s_akt1_re3( Survival ):
PMID:15534002
PMID:9779982
PMID:14585353
PtdIns(4,5)-P2@Cytoplasm
References
s_wca1_re31( Survival ):
PMID:19561074
PI4KIIalpha and PIP5KIbeta are in complex together with DVL. To keep complex clear the enzymes are left outside of this complex
s_wca1_re59:( Survival ) PMID:21304492
Modifications:
In compartment: Cytoplasm
- PtdIns(4,5)-P2@Cytoplasm
In compartment: Lipid Raft
- PtdIns(4,5)-P2@Lipid Raft
Participates in complexes:
In compartment: Cytoplasm
- AMER1*:PtdIns(4,5)-P2@Cytoplasm
- AMER1*:CK1_gamma_*:PtdIns(4,5)-P2@Cytoplasm
- AMER1*:APC:AXIN*:CK1_alpha_*:GSK3*:PtdIns(4,5)-P2@Cytoplasm
- AMER1*:APC:AXIN*|S80_pho|S82_pho|S222_pho|S473_pho:CK1_alpha_*:GSK3*:PtdIns(4,5)-P2@Cytoplasm
- AMER1*:APC:AXIN*|S80_pho|S82_pho|S222_pho|S473_pho|S614_emp|S621_pho:CK1_alpha_*:GSK3*:PtdIns(4,5)-P2@Cytoplasm
- AMER1*:APC:AXIN*|S80_pho|S82_pho|S222_pho|S473_pho|S614_pho|S621_pho:CK1_alpha_*:GSK3*:PtdIns(4,5)-P2@Cytoplasm
- AMER1*:APC:AXIN*|S80_pho|S82_pho|S222_pho|S473_pho|S614_pho|S621_pho:CK1_alpha_*:GSK3*:PtdIns(4,5)-P2:_beta_-Catenin*@Cytoplasm
- AMER1*:APC:AXIN*|S80_pho|S82_pho|S222_pho|S473_pho|S614_pho|S621_pho:CK1_alpha_*:GSK3*:PtdIns(4,5)-P2:_beta_-Catenin*|S45_pho@Cytoplasm
- AMER1*:APC:AXIN*|S80_pho|S82_pho|S222_pho|S473_pho|S614_pho|S621_pho:CK1_alpha_*:GSK3*:PtdIns(4,5)-P2:_beta_-Catenin*|S45_pho|T41_pho@Cytoplasm
- AMER1*:APC:AXIN*|S80_pho|S82_pho|S222_pho|S473_pho|S614_pho|S621_pho:CK1_alpha_*:GSK3*:PtdIns(4,5)-P2:_beta_-Catenin*|S45_pho|T41_pho|S37_pho@Cytoplasm
- AMER1*:APC:AXIN*|S80_pho|S82_pho|S222_pho|S473_pho|S614_pho|S621_pho:CK1_alpha_*:GSK3*:PtdIns(4,5)-P2:_beta_-Catenin*|S45_pho|T41_pho|S37_pho|S33_pho@Cytoplasm
- AMER1*:APC|S1505_pho:AXIN*|S80_pho|S82_pho|S222_pho|S473_pho|S614_pho|S621_pho:CK1_alpha_*:GSK3*:PtdIns(4,5)-P2:_beta_-Catenin*|S45_pho|T41_pho|S37_pho|S33_pho@Cytoplasm
- AMER1*:APC|S1505_pho|S1501_pho:AXIN*|S80_pho|S82_pho|S222_pho|S473_pho|S614_pho|S621_pho:CK1_alpha_*:GSK3*:PtdIns(4,5)-P2:_beta_-Catenin*|S45_pho|T41_pho|S37_pho|S33_pho@Cytoplasm
- AMER1*:APC|S1505_pho|S1501_pho|S1504_pho:AXIN*|S80_pho|S82_pho|S222_pho|S473_pho|S614_pho|S621_pho:CK1_alpha_*:GSK3*:PtdIns(4,5)-P2:_beta_-Catenin*|S45_pho|T41_pho|S37_pho|S33_pho@Cytoplasm
- AMER1*:APC|S1505_pho|S1501_pho|S1504_pho|S1507_pho:AXIN*|S80_pho|S82_pho|S222_pho|S473_pho|S614_pho|S621_pho:CK1_alpha_*:GSK3*:PtdIns(4,5)-P2:_beta_-Catenin*|S45_pho|T41_pho|S37_pho|S33_pho@Cytoplasm
- AMER1*:APC|S1505_pho|S1501_pho|S1504_pho|S1507_pho|S1503_pho|S1510_pho:AXIN*|S80_pho|S82_pho|S222_pho|S473_pho|S614_pho|S621_pho:CK1_alpha_*:GSK3*:PtdIns(4,5)-P2:_beta_-Catenin*|S45_pho|T41_pho|S37_pho|S33_pho@Cytoplasm
- AMER1*:APC|S1505_pho|S1501_pho|S1504_pho|S1507_pho|S1503_pho|S1510_pho:AXIN*|S80_pho|S82_pho|S222_pho|S473_pho|S614_pho|S621_pho:CK1_alpha_*:CK2_alpha_'*:CK2_alpha_*:CK2_beta_*:CSN1*:CSN2*:CSN3*:CSN4*:CSN5*:CSN6*:CSN7*:CSN8*:CUL1:E1*:FAF*:GSK3*:NEDD8:PKD*:PtdIns(4,5)-P2:RAD6*:RBX1:SKP*:USP15:_beta_-Catenin*|S45_pho|T41_pho|S37_pho|S33_pho|K19_ubi|K49_ubi:_beta_TRCP*@Cytoplasm
Participates in reactions:
As Reactant or Product:- PtdIns(4,5)-P2@Lipid Raft → PI3,4,5-P3@Lipid Raft
- PI3,4,5-P3@Lipid Raft → PtdIns(4,5)-P2@Lipid Raft
- AMER1*:APC:AXIN*|S80_pho|S82_pho|S222_pho|S473_pho|S614_pho|S621_pho:CK1_alpha_*:GSK3*:PtdIns(4,5)-P2@Cytoplasm + _beta_-Catenin*@Cytoplasm → AMER1*:APC:AXIN*|S80_pho|S82_pho|S222_pho|S473_pho|S614_pho|S621_pho:CK1_alpha_*:GSK3*:PtdIns(4,5)-P2:_beta_-Catenin*@Cytoplasm
- AMER1*:APC|S1505_pho|S1501_pho|S1504_pho|S1507_pho:AXIN*|S80_pho|S82_pho|S222_pho|S473_pho|S614_pho|S621_pho:CK1_alpha_*:GSK3*:PtdIns(4,5)-P2:_beta_-Catenin*|S45_pho|T41_pho|S37_pho|S33_pho@Cytoplasm → AMER1*:APC|S1505_pho|S1501_pho|S1504_pho|S1507_pho|S1503_pho|S1510_pho:AXIN*|S80_pho|S82_pho|S222_pho|S473_pho|S614_pho|S621_pho:CK1_alpha_*:GSK3*:PtdIns(4,5)-P2:_beta_-Catenin*|S45_pho|T41_pho|S37_pho|S33_pho@Cytoplasm
- AMER1*:APC:AXIN*|S80_pho|S82_pho|S222_pho|S473_pho:CK1_alpha_*:GSK3*:PtdIns(4,5)-P2@Cytoplasm → AMER1*:APC:AXIN*|S80_pho|S82_pho|S222_pho|S473_pho|S614_emp|S621_pho:CK1_alpha_*:GSK3*:PtdIns(4,5)-P2@Cytoplasm
- AMER1*:APC:AXIN*|S80_pho|S82_pho|S222_pho|S473_pho|S614_emp|S621_pho:CK1_alpha_*:GSK3*:PtdIns(4,5)-P2@Cytoplasm → AMER1*:APC:AXIN*|S80_pho|S82_pho|S222_pho|S473_pho|S614_pho|S621_pho:CK1_alpha_*:GSK3*:PtdIns(4,5)-P2@Cytoplasm
- AMER1*:APC:AXIN*|S80_pho|S82_pho|S222_pho|S473_pho:CK1_alpha_*:GSK3*:PtdIns(4,5)-P2@Cytoplasm + PPP1C*:PPP1R*@Cytoplasm → AMER1*:APC:AXIN*|S80_pho|S82_pho|S222_pho|S473_pho:CK1_alpha_*:GSK3*:PPP1C*:PPP1R*@Cytoplasm
- APC:AXIN*|S80_emp|S82_emp|S222_emp|S473_emp:CK1_alpha_*:GSK3*:PPP1C*:PPP1R*@Cytoplasm → GSK3*@Cytoplasm + AMER1*:APC:AXIN*:CK1_alpha_*:GSK3*:PtdIns(4,5)-P2@Cytoplasm + PPP1C*:PPP1R*@Cytoplasm
- AMER1*:APC:AXIN*|S80_pho|S82_pho|S222_pho|S473_pho|S614_pho|S621_pho:CK1_alpha_*:GSK3*:PtdIns(4,5)-P2:_beta_-Catenin*@Cytoplasm → AMER1*:APC:AXIN*|S80_pho|S82_pho|S222_pho|S473_pho|S614_pho|S621_pho:CK1_alpha_*:GSK3*:PtdIns(4,5)-P2:_beta_-Catenin*|S45_pho@Cytoplasm
- AMER1*:APC:AXIN*|S80_pho|S82_pho|S222_pho|S473_pho|S614_pho|S621_pho:CK1_alpha_*:GSK3*:PtdIns(4,5)-P2:_beta_-Catenin*|S45_pho|T41_pho|S37_pho|S33_pho@Cytoplasm + PP2A_C*:PR55_alpha_*:PR65_A*@Cytoplasm → AMER1*:APC:AXIN*|S80_pho|S82_pho|S222_pho|S473_pho|S614_pho|S621_pho:CK1_alpha_*:GSK3*:PP2A_C*:PR55_alpha_*:PR65_A*:_beta_-Catenin*|S45_pho|T41_pho|S37_pho|S33_pho@Cytoplasm
- APC:AXIN*|S80_pho|S82_pho|S222_pho|S473_pho|S614_pho|S621_pho:CK1_alpha_*:GSK3*:PP2A_C*:PR55_alpha_*:PR65_A*:_beta_-Catenin*|S45_emp|T41_emp|S37_emp|S33_emp@Cytoplasm → PP2A_C*:PR55_alpha_*:PR65_A*@Cytoplasm + _beta_-Catenin*@Cytoplasm + AMER1*:APC:AXIN*|S80_pho|S82_pho|S222_pho|S473_pho|S614_pho|S621_pho:CK1_alpha_*:GSK3*:PtdIns(4,5)-P2@Cytoplasm
- DVL*|pho|emp|emp:G_beta_*:G_gamma_*:_beta_-Arrestin2*@Cytoplasm + CK1_epsilon_*:E-Cadherin*:FZD*:GTP:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:PRR*:WNT*:p120*@Vaceolae + AMER1*:CK1_gamma_*:PtdIns(4,5)-P2@Cytoplasm → AMER1*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*:FZD*:G_beta_*:G_gamma_*:LRP5_6*:PRR*:WNT*:_beta_-Arrestin2*:p120*@Vaceolae + GTP:G_alpha_o*@Cytoplasm + G_beta_*:G_gamma_*@Cytoplasm
- AMER1*:APC:AXIN*|S80_pho|S82_pho|S222_pho|S473_pho|S614_pho|S621_pho:CK1_alpha_*:GSK3*:PtdIns(4,5)-P2:_beta_-Catenin*|S45_pho@Cytoplasm → AMER1*:APC:AXIN*|S80_pho|S82_pho|S222_pho|S473_pho|S614_pho|S621_pho:CK1_alpha_*:GSK3*:PtdIns(4,5)-P2:_beta_-Catenin*|S45_pho|T41_pho@Cytoplasm
- PtdIns(4)-P@Cytoplasm → PtdIns(4,5)-P2@Cytoplasm
- AXIN*:CK1_alpha_*:GSK3*@Cytoplasm + APC@Cytoplasm + AMER1*@Cytoplasm → AMER1*:APC:AXIN*:CK1_alpha_*:GSK3*:PtdIns(4,5)-P2@Cytoplasm
- AMER1*:APC:AXIN*|S80_pho|S82_pho|S222_pho|S473_pho|S614_pho|S621_pho:CK1_alpha_*:GSK3*:PtdIns(4,5)-P2:_beta_-Catenin*|S45_pho|T41_pho@Cytoplasm → AMER1*:APC:AXIN*|S80_pho|S82_pho|S222_pho|S473_pho|S614_pho|S621_pho:CK1_alpha_*:GSK3*:PtdIns(4,5)-P2:_beta_-Catenin*|S45_pho|T41_pho|S37_pho@Cytoplasm
- AMER1*:APC:AXIN*:CK1_alpha_*:GSK3*:PtdIns(4,5)-P2@Cytoplasm → AMER1*:APC:AXIN*|S80_pho|S82_pho|S222_pho|S473_pho:CK1_alpha_*:GSK3*:PtdIns(4,5)-P2@Cytoplasm
- AMER1*:APC|S1505_pho|S1501_pho|S1504_pho|S1507_pho|S1503_pho|S1510_pho:AXIN*|S80_pho|S82_pho|S222_pho|S473_pho|S614_pho|S621_pho:CK1_alpha_*:GSK3*:PtdIns(4,5)-P2:_beta_-Catenin*|S45_pho|T41_pho|S37_pho|S33_pho@Cytoplasm + CUL1:E1*:FAF*:NEDD8:RAD6*:RBX1:SKP*:_beta_TRCP*@Cytoplasm + CK2_alpha_'*:CK2_alpha_*:CK2_beta_*:CSN1*:CSN2*:CSN3*:CSN4*:CSN5*:CSN6*:CSN7*:CSN8*:PKD*:USP15@Cytoplasm → AMER1*:APC|S1505_pho|S1501_pho|S1504_pho|S1507_pho|S1503_pho|S1510_pho:AXIN*|S80_pho|S82_pho|S222_pho|S473_pho|S614_pho|S621_pho:CK1_alpha_*:CK2_alpha_'*:CK2_alpha_*:CK2_beta_*:CSN1*:CSN2*:CSN3*:CSN4*:CSN5*:CSN6*:CSN7*:CSN8*:CUL1:E1*:FAF*:GSK3*:NEDD8:PKD*:PtdIns(4,5)-P2:RAD6*:RBX1:SKP*:USP15:_beta_-Catenin*|S45_pho|T41_pho|S37_pho|S33_pho|K19_ubi|K49_ubi:_beta_TRCP*@Cytoplasm
- AMER1*:APC|S1505_pho|S1501_pho|S1504_pho|S1507_pho|S1503_pho|S1510_pho:AXIN*|S80_pho|S82_pho|S222_pho|S473_pho|S614_pho|S621_pho:CK1_alpha_*:CK2_alpha_'*:CK2_alpha_*:CK2_beta_*:CSN1*:CSN2*:CSN3*:CSN4*:CSN5*:CSN6*:CSN7*:CSN8*:CUL1:E1*:FAF*:GSK3*:NEDD8:PKD*:PtdIns(4,5)-P2:RAD6*:RBX1:SKP*:USP15:_beta_-Catenin*|S45_pho|T41_pho|S37_pho|S33_pho|K19_ubi|K49_ubi:_beta_TRCP*@Cytoplasm → CK2_alpha_'*:CK2_alpha_*:CK2_beta_*:CSN1*:CSN2*:CSN3*:CSN4*:CSN5*:CSN6*:CSN7*:CSN8*:CUL1:NEDD8:PKD*:RAD6*:RBX1:SKP*:USP15:_beta_TRCP*@Cytoplasm + APC|S1505_pho|S1501_ubi|S1504_pho|S1507_pho|S1503_pho|S1510_ubi:AXIN*|S80_pho|S82_pho|S222_pho|S473_pho|S614_pho|S621_pho@Cytoplasm + _beta_-Catenin*|S45_pho|T41_pho|S37_pho|S33_pho|K19_ubi|K49_ubi@Cytoplasm
- AMER1*:APC:AXIN*|S80_pho|S82_pho|S222_pho|S473_pho|S614_pho|S621_pho:CK1_alpha_*:GSK3*:PtdIns(4,5)-P2:_beta_-Catenin*|S45_pho|T41_pho|S37_pho@Cytoplasm → AMER1*:APC:AXIN*|S80_pho|S82_pho|S222_pho|S473_pho|S614_pho|S621_pho:CK1_alpha_*:GSK3*:PtdIns(4,5)-P2:_beta_-Catenin*|S45_pho|T41_pho|S37_pho|S33_pho@Cytoplasm
- PtdIns(4,5)-P2@Cytoplasm + AMER1*@Cytoplasm → AMER1*:PtdIns(4,5)-P2@Cytoplasm
- AMER1*:APC:AXIN*|S80_pho|S82_pho|S222_pho|S473_pho|S614_pho|S621_pho:CK1_alpha_*:GSK3*:PtdIns(4,5)-P2:_beta_-Catenin*|S45_pho|T41_pho|S37_pho|S33_pho@Cytoplasm → AMER1*:APC|S1505_pho:AXIN*|S80_pho|S82_pho|S222_pho|S473_pho|S614_pho|S621_pho:CK1_alpha_*:GSK3*:PtdIns(4,5)-P2:_beta_-Catenin*|S45_pho|T41_pho|S37_pho|S33_pho@Cytoplasm
- CK1_gamma_*@Cytoplasm + AMER1*:PtdIns(4,5)-P2@Cytoplasm → AMER1*:CK1_gamma_*:PtdIns(4,5)-P2@Cytoplasm
- AMER1*:APC|S1505_pho:AXIN*|S80_pho|S82_pho|S222_pho|S473_pho|S614_pho|S621_pho:CK1_alpha_*:GSK3*:PtdIns(4,5)-P2:_beta_-Catenin*|S45_pho|T41_pho|S37_pho|S33_pho@Cytoplasm → AMER1*:APC|S1505_pho|S1501_pho:AXIN*|S80_pho|S82_pho|S222_pho|S473_pho|S614_pho|S621_pho:CK1_alpha_*:GSK3*:PtdIns(4,5)-P2:_beta_-Catenin*|S45_pho|T41_pho|S37_pho|S33_pho@Cytoplasm
- Cell-cell adhesions@Extracellular space → AMER1*:PtdIns(4,5)-P2@Cytoplasm
- AMER1*:APC|S1505_pho|S1501_pho:AXIN*|S80_pho|S82_pho|S222_pho|S473_pho|S614_pho|S621_pho:CK1_alpha_*:GSK3*:PtdIns(4,5)-P2:_beta_-Catenin*|S45_pho|T41_pho|S37_pho|S33_pho@Cytoplasm → AMER1*:APC|S1505_pho|S1501_pho|S1504_pho:AXIN*|S80_pho|S82_pho|S222_pho|S473_pho|S614_pho|S621_pho:CK1_alpha_*:GSK3*:PtdIns(4,5)-P2:_beta_-Catenin*|S45_pho|T41_pho|S37_pho|S33_pho@Cytoplasm
- AMER1*:APC|S1505_pho|S1501_pho|S1504_pho:AXIN*|S80_pho|S82_pho|S222_pho|S473_pho|S614_pho|S621_pho:CK1_alpha_*:GSK3*:PtdIns(4,5)-P2:_beta_-Catenin*|S45_pho|T41_pho|S37_pho|S33_pho@Cytoplasm → AMER1*:APC|S1505_pho|S1501_pho|S1504_pho|S1507_pho:AXIN*|S80_pho|S82_pho|S222_pho|S473_pho|S614_pho|S621_pho:CK1_alpha_*:GSK3*:PtdIns(4,5)-P2:_beta_-Catenin*|S45_pho|T41_pho|S37_pho|S33_pho@Cytoplasm
As Catalyser:- AMER1*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*:FZD*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho:PRR*:WNT*:_beta_-Arrestin2*:p120*@Vaceolae + AXIN*:CK1_alpha_*:GSK3*:G_alpha_o*:_beta_-Arrestin2*@Cytoplasm → AMER1*:AXIN*:CK1_alpha_*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho:PRR*:WNT*:_beta_-Arrestin2*:p120*@Endosome
- AMER1*:AXIN*:CK1_alpha_*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho:PRR*:WNT*:_beta_-Arrestin2*:p120*@Endosome + AXIN*:CK1_alpha_*:GSK3*:G_alpha_o*:_beta_-Arrestin2*@Cytoplasm → AMER1*:AXIN*:CK1_alpha_*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho:PRR*:WNT*:_beta_-Arrestin2*:p120*@Endosome
- APC:Microtubules@Cytoplasm → APC@Cytoplasm + Microtubules@Cytoplasm