ERK*:KSR1:MEK*

Complex ERK*:KSR1:MEK*

Complex composition:

ERK*|pho|pho:KSR1:MEK*|pho|pho@Cytoplasm

Identifiers
NAME:ERK*:KSR1:MEK*

References
su_mpk1_mpk1_re81( Survival ):
Docking of activated ERK to the KSR1 scaffold negatively regulates the interaction between KSR1 and B-Raf.
PMID:19541618
su_mpk1_mpk1_re83( Survival ):
Upon activation scaffold proteins serve as platforms in which ERK dimers are assembled forming complexes capable of interacting with and activating cognate cytoplasmic substrates.
PMID:18775330
su_mpk1_mpk1_re189( Survival ):
MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. A direct interaction between P38 and ERK has been proposed as a mechanism to inhibit ERK phosphorylation. AP-1 mediated gene expression inhibits ERK phosphorylation.
PMID:18039929

ERK*|pho|pho|hm2:KSR1:MEK*|pho|pho@Cytoplasm

Identifiers
NAME:ERK*:KSR1:MEK*

References
su_mpk1_mpk1_re83( Survival ):
Upon activation scaffold proteins serve as platforms in which ERK dimers are assembled forming complexes capable of interacting with and activating cognate cytoplasmic substrates.
PMID:18775330
su_mpk1_mpk1_re82( Survival ):
Results supported the notion that KSR1 coupled activated ERK1/2 selectively to its substrate cPLA2 (PLA2G4A) in response to signals generated at lipid rafts.
MAPKs activate cPLA2 (PLA2G4A) by phosphorylation.
PMID:19114553 PMID:8381049

Modifications:
Participates in complexes:
In compartment: Cytoplasm

Participates in reactions:
As Reactant or Product:

As Catalyser:

PLA2G4A@Cytoplasm → PLA2G4A|pho@Cytoplasm