Protein p110* map

Identifiers
HUGO:PIK3CA HGNC:8975 ENTREZ:5290 UNIPROT:P42336 GENECARDS:PIK3CA HUGO:PIK3CB HGNC:8976 ENTREZ:5291 UNIPROT:P42338 GENECARDS:PIK3CB HUGO:PIK3CD HGNC:8977 ENTREZ:5293 UNIPROT:O00329 GENECARDS:PIK3CD HUGO:PIK3CG HGNC:8978 ENTREZ:5294 UNIPROT:P48736 GENECARDS:PIK3CG
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
HUGO:PIK3CA hgnc_id:HGNC:8975 HGNC:8975 ENTREZ:5290 UNIPROT:P42336
DSN1 homolog, MIS12 kinetochore complex component
HUGO:DSN1 hgnc_id:HGNC:16165 HGNC:16165 ENTREZ:79980 UNIPROT:Q9H410
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
HUGO:PIK3CB hgnc_id:HGNC:8976 HGNC:8976 ENTREZ:5291 UNIPROT:P42338
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
HUGO:PIK3CD hgnc_id:HGNC:8977 HGNC:8977 ENTREZ:5293 UNIPROT:O00329
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
HUGO:PIK3CG hgnc_id:HGNC:8978 HGNC:8978 ENTREZ:5294 UNIPROT:P48736
"phosphoinositide-3-kinase catalytic alpha polypeptide"
HUGO:PIK3CA HGNC:8975 ENTREZ:5290 UNIPROT:P42336
phosphoinositide-3-kinase, catalytic, alpha polypeptide
HUGO:PIK3CA HGNC:8975 ENTREZ:5290 UNIPROT:P42336 GENECARDS:PIK3CA REACTOME:61074 KEGG:5290 ATLASONC:PIK3CAID415ch3q26 WIKI:PIK3CA
phosphoinositide-3-kinase, catalytic, beta polypeptide
HUGO:PIK3CB HGNC:8976 ENTREZ:5291 UNIPROT:P42338 GENECARDS:PIK3CB REACTOME:61076 KEGG:5291 ATLASONC:GC_PIK3CB WIKI:PIK3CB
phosphoinositide-3-kinase, catalytic, delta polypeptide
HUGO:PIK3CD HGNC:8977 ENTREZ:5293 UNIPROT:O00329 GENECARDS:PIK3CD REACTOME:61078 KEGG:5293 ATLASONC:PIK3CDID46261ch1p36 WIKI:PIK3CD
phosphoinositide-3-kinase, catalytic, gamma polypeptide
HUGO:PIK3CG HGNC:8978 ENTREZ:5294 UNIPROT:P48736 GENECARDS:PIK3CG REACTOME:61080 KEGG:5294 ATLASONC:GC_PIK3CG WIKI:PIK3CG

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / TCR_SIGNALING  map
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / CORE  map
 Innate Immunity  map  / IMMUNOSTIMULATORY_CORE_PATHWAYS  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / MAPK  map
 Survival  map  / HEDGEHOG  map
 Survival  map  / PI3K_AKT_MTOR  map
 RECON2  map

References
PMID:12670391 PMID:26552706
REACTOME:61074 KEGG:5290 ATLASONC:PIK3CAID415ch3q26 WIKI:PIK3CA
phosphoinositide-3-kinase, catalytic, beta polypeptide
REACTOME:61076 KEGG:5291 ATLASONC:GC_PIK3CB WIKI:PIK3CB
phosphoinositide-3-kinase, catalytic, delta polypeptide
REACTOME:61078 KEGG:5293 ATLASONC:PIK3CDID46261ch1p36 WIKI:PIK3CD
phosphoinositide-3-kinase, catalytic, gamma polypeptide
REACTOME:61080 KEGG:5294 ATLASONC:GC_PIK3CG WIKI:PIK3CG
CASCADE:PDGF
CASCADE:FGF
CASCADE:GAST
PMID:23523669
Progastrin-induced secretion of insulin-like growth factor 2 from colonic myofibroblasts stimulates colonic epithelial proliferation in mice.
Incubation of CCD18Co myofibroblasts with 0.1 nmol/L rhPG(1-80) increased their proliferation, which required activation of protein kinase C and phosphatidylinositol-3 kinase.
PMID:11447289
PMID:27111285
ILK???PI3K/AKT pathway participates in cutaneous wound contraction by regulating fibroblast migration and differentiation to myofibroblast
 NATURAL_KILLER  map
 MACROPHAGE  map
 DENDRITIC_CELL  map
CASCADE:IL4
CASCADE:NKP80
CASCADE:NKG2D
CASCADE:NKP46
CASCADE:IL15
CASCADE:IL21
CASCADE:CSF2
CASCADE:IFNAB
CASCADE:IFNG
PMID:11062502, PMID:11385609, PMID:11907067, PMID:15536084
Nkp46 controls NK cytolitic activity via PI3K /RAC1/PAK1/MEK??/ERK pathway, probably throught SYK
PMID:12040186
The regulatory subunit maintains the p110 catalytic subunit in a low-activity state in quiescent cells and mediates its activation by direct interaction with phosphotyrosine residues of activated growth factor receptors or adaptor proteins. Direct binding of p110 to activated Ras protein (also induced by growth factor stimulation) further stimulates PI3K activity. The activated PI3K converts the plasma membrane lipid phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] to phosphatidylinositol-3,4,5-trisphosphate [PI(3,4,5)P3].
PMID:11062502, PMID:11385609
PI3K /RAC1/PAK1/MEK??/ERK pathway controls NK cytolitic activity downstream of NKp30 and NKp46.
PMID:18287025
NKG2D-mediated cytotoxicity is PI3K-dependent.
PMID:8294866
Phosphatidylinositol-3 kinase activation induced upon Fc gamma RIIIA-ligand interaction
in NK cells
PMID:20805416
In differentiating moDCs, the PI3K/Akt-dependent mTOR pathway was constitutively activated by GM-CSF
And this signaling is needful for DC differentiation.
PMID:16847462

p110*@Cytoplasm

References
su_mpk1_mpk1_re265( Survival  map ):
Grb2 recruits the docking protein Gab1 which is tyrosine phosphorylated by FGFR leading to recruitment and activation of the PI3K-Akt cell survival pathway.
PMID:15567848

p110*|​pho@Cytoplasm

References
su_mpk1_mpk1_re265( Survival  map ):
Grb2 recruits the docking protein Gab1 which is tyrosine phosphorylated by FGFR leading to recruitment and activation of the PI3K-Akt cell survival pathway.
PMID:15567848
su_mpk1_mpk1_re266( Survival  map ):
PDK1 is a PI3K target leading to activation of P70 and subsequent cell growth. Signaling proteins with pleckstrin-homology (PH) domains accumulate at sites of PI3K activation by directly binding to PI(345)P3. Of particular interest are the protein serine-threonine kinases Akt and phosphoinositide-dependent kinase 1 (PDK1). Association with PI(345)P3 at the membrane brings these proteins into proximity and facilitates phosphorylation of Akt by PDK1. This phosphorylation stimulates the catalytic activity of Akt resulting in the phosphorylation of a host of other proteins that affect cell growth cell cycle entry and cell survival.
PMID:12040186
su_mpk1_mpk1_re284( Survival  map ):
Grb2 recruits the docking protein Gab1 which is tyrosine phosphorylated by EGFR or FGFR leading to recruitment and activation of the PI3K-Akt cell survival pathway.
Recruitment of PI 3-kinase by Gab1 results in a positive-feedback loop mediated by binding of the PH domain of Gab1 to the product of PI3-kinase activation phosphatidylinositol-345-triphosphate.
PMID:15567848 PMID:15199124

Modifications:
In compartment: Cytoplasm
  1. p110*@Cytoplasm map
  2. p110*|​pho@Cytoplasm map
In compartment: Cytosol
  1. p110*@Cytosol map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. p110*@INNATE_IMMUNE_CELL_Cytosol map
In compartment: T_cell
  1. p110*@T_cell map
Participates in complexes:
In compartment: Cytoplasm
  1. p110*:​p85*@Cytoplasm map
In compartment: Cytosol
  1. p110*:​p85*@Cytosol map
  2. C-FES*|​Y713_pho|​Y811_pho|​hm2:​p110*:​p85*@Cytosol map
In compartment: Endosome
  1. GAB1:​GF:​GRB2:​PI3,4,5-P3:​RAS*:​RTK*|​pho|​pho|​hm2:​SOS*:​p110*:​p85*@Endosome map
In compartment: Lipid Raft
  1. RAS*:​p110*:​p85*@Lipid Raft map
  2. GF:​RTK*|​pho|​pho|​hm2:​p110*:​p85*@Lipid Raft map
  3. GAB1|​Y977_pho|​Y989_pho:​GF:​GRB2:​PI3,4,5-P3:​RAS*:​RTK*|​pho|​pho|​hm2:​SOS*:​p110*:​p85*@Lipid Raft map
Participates in reactions:
As Reactant or Product:
  1. p110*@T_cell map → map p110*@T_cell map
  2. p110*@Cytosol map → map p110*@Cytosol map
  3. p110*@INNATE_IMMUNE_CELL_Cytosol map → map p110*@INNATE_IMMUNE_CELL_Cytosol map
  4. p110*:​p85*@Cytoplasm map + GRB2:​SOS*@Cytoplasm map + PI3,4,5-P3@Lipid Raft map + RTK*@Cytoplasm map + GF@default map + RAS*@Cytoplasm map + GAB1|​Y977_pho|​Y989_pho@Cytoplasm map → map GAB1|​Y977_pho|​Y989_pho:​GF:​GRB2:​PI3,4,5-P3:​RAS*:​RTK*|​pho|​pho|​hm2:​SOS*:​p110*:​p85*@Lipid Raft map
  5. GAB1:​GF:​GRB2:​PI3,4,5-P3:​RAS*:​RTK*|​pho|​pho|​hm2:​SOS*:​p110*:​p85*@Endosome map → map Ubiquitination@Cytoplasm map
  6. GAB1|​Y977_pho|​Y989_pho:​GF:​GRB2:​PI3,4,5-P3:​RAS*:​RTK*|​pho|​pho|​hm2:​SOS*:​p110*:​p85*@Lipid Raft map → map GAB1:​GF:​GRB2:​PI3,4,5-P3:​RAS*:​RTK*|​pho|​pho|​hm2:​SOS*:​p110*:​p85*@Endosome map
  7. GF:​RTK*|​pho|​pho|​hm2@Lipid Raft map + p110*:​p85*@Cytoplasm map → map GF:​RTK*|​pho|​pho|​hm2:​p110*:​p85*@Lipid Raft map
  8. p110*:​p85*@Cytoplasm map + RAS*@Cytoplasm map → map RAS*:​p110*:​p85*@Lipid Raft map
  9. p110*@Cytoplasm map → map p110*|​pho@Cytoplasm map
  10. C-FES*|​Y713_pho|​Y811_pho|​hm2|​active@Cytosol map + p110*:​p85*@Cytosol map → map C-FES*|​Y713_pho|​Y811_pho|​hm2:​p110*:​p85*@Cytosol map
  11. C-FES*|​Y713_pho|​Y811_pho|​hm2:​p110*:​p85*@Cytosol map → map PI3K AKT MTOR pathway@Cytosol map
As Catalyser:
  1. PIP2*@T_cell map → map PIP3*@T_cell map
  2. gBCL2L1@T_cell map → map rBCL2L1@T_cell map
  3. PIP2*@Cytosol map → map PIP3*@Cytosol map
  4. PIP2*@INNATE_IMMUNE_CELL_Cytosol map → map PIP3*@INNATE_IMMUNE_CELL_Cytosol map
  5. DAG:​PRKCQ@INNATE_IMMUNE_CELL_Cytosol map → map DAG:​PRKCQ|​pho@INNATE_IMMUNE_CELL_Cytosol map
  6. PtdIns(4,5)-P2@Lipid Raft map → map PI3,4,5-P3@Lipid Raft map
  7. PKD1@Cytoplasm map → map PKD1|​unk@Cytoplasm map
  8. GAB1:​GRB2@Cytoplasm map → map GAB1|​pho:​GRB2@Cytoplasm map