Simple molecule DAG map
DAG@T_cell

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / TCR_SIGNALING  map

References
PMID:18784374 PMID:23077238 PMID:25456276

DAG@INNATE_IMMUNE_CELL_Cytosol

References
CASCADE:IFNAB
PMID:18784374, PMID:23077238
PKC-theta requires DAG for activation. DAG is generated by PLCG through enzymatic cleavage of PIP2

DAG@Plasma Membrane

Identifiers
Diacylglycerol
CAS:N/A PUBCHEM:3914 CHEBI:17815 KEGGCOMPOUND:C00165

References
su_mpk1_mpk1_re45( Survival  map ):
PLCG acts on PIP2 in the PM to produce DAG and IP3.
PMID:16488589
IP3 diffuses through the cytosol and binds to receptors on the endoplasmic reticulum causing the release of calcium ions (Ca2+) into the cytosol.
http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Second_messengers.html
su_mpk1_mpk1_re46( Survival  map ):
RasGRP1 is a C1-domain containing protein that is activated by DAG and Ca2+ in a manner analogous to members of the PKC family.
PMID:17496910
DAG remains in the inner layer of the plasma membrane. It recruits Protein Kinase C (PKC) ??? a calcium-dependent kinase that phosphorylates many other proteins that bring about the changes in the cell.
su_mpk1_mpk1_re263( Survival  map ):
Recruitment to the membrane and tyrosine phosphorylation enhance the enzymatic activity of PLC-g leading to the formation of two second messengers diacylglycerol (DAG) and inositol 145-trisphosphate (IP3). IP3 releases Ca2+ from internal stores which in turn acts in concert with DAG to translocate protein kinase C (PKC) to the cell membrane and stimulate its enzymatic activity.
PMID:15567848

DAG@Cytoplasm

References
Ca2+/Wnt MODULE
s_wnc1_re26:( Survival  map ) PMID:16054198

Modifications:
In compartment: Cytoplasm
  1. DAG@Cytoplasm map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. DAG@INNATE_IMMUNE_CELL_Cytosol map
In compartment: Plasma Membrane
  1. DAG@Plasma Membrane map
In compartment: T_cell
  1. DAG@T_cell map
Participates in complexes:
In compartment: Cytosol
  1. (DAG:​PKC*)|​active@Cytosol map
In compartment: Golgi Apparatus
  1. Ca2+:​DAG:​RASGRP1@Golgi Apparatus map
  2. Ca2+:​DAG:​RAS*|​pho:​RASGRP1@Golgi Apparatus map
  3. Ca2+:​DAG:​RAF1|​pho:​RAS*|​pho:​RASGRP1@Golgi Apparatus map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. DAG:​PRKCQ@INNATE_IMMUNE_CELL_Cytosol map
  2. DAG:​PRKCQ|​pho@INNATE_IMMUNE_CELL_Cytosol map
In compartment: Plasma Membrane
  1. DAG:​RASGRP1@Plasma Membrane map
  2. Ca2+:​DAG:​PKC*@Plasma Membrane map
  3. Ca2+:​DAG:​RASGRP1@Plasma Membrane map
In compartment: T_cell
  1. DAG:​PRKCQ@T_cell map
  2. DAG:​RASGRP1@T_cell map
In compartment: cSMAC
  1. DAG:​PRKCQ@cSMAC map
  2. (DAG:​PRKCQ|​pho)|​active@cSMAC map
Participates in reactions:
As Reactant or Product:
  1. PRKCQ@T_cell map + DAG@T_cell map → map DAG:​PRKCQ@T_cell map
  2. PIP2*@T_cell map → map IP3@T_cell map + DAG@T_cell map
  3. DAG:​PRKCQ@cSMAC map → map (DAG:​PRKCQ|​pho)|​active@cSMAC map
  4. DAG:​PRKCQ@T_cell map → map DAG:​PRKCQ@cSMAC map
  5. RASGRP1@T_cell map + DAG@T_cell map → map DAG:​RASGRP1@T_cell map
  6. PKC*@Cytosol map + DAG@Cytosol map → map (DAG:​PKC*)|​active@Cytosol map
  7. (DAG:​PKC*)|​active@Cytosol map → map Fibroblast_proliferation@Cytosol map
  8. PI4,5-P2@INNATE_IMMUNE_CELL_Cytosol map → map DAG@INNATE_IMMUNE_CELL_Cytosol map + IP3@INNATE_IMMUNE_CELL_Cytosol map
  9. DAG@INNATE_IMMUNE_CELL_Cytosol map + PRKCQ@INNATE_IMMUNE_CELL_Cytosol map → map DAG:​PRKCQ@INNATE_IMMUNE_CELL_Cytosol map
  10. DAG:​PRKCQ@INNATE_IMMUNE_CELL_Cytosol map → map DAG:​PRKCQ|​pho@INNATE_IMMUNE_CELL_Cytosol map
  11. PKC*@Cytoplasm map + DAG@Plasma Membrane map + Ca2+@Cytoplasm map → map Ca2+:​DAG:​PKC*@Plasma Membrane map
  12. RAS*@Plasma Membrane map + Ca2+:​DAG:​RASGRP1@Golgi Apparatus map → map Ca2+:​DAG:​RAS*|​pho:​RASGRP1@Golgi Apparatus map
  13. PIP2@Plasma Membrane map → map IP3@Endoplasmic Reticulum map + DAG@Plasma Membrane map
  14. DAG@Plasma Membrane map + RASGRP1@Cytoplasm map → map DAG:​RASGRP1@Plasma Membrane map
  15. DAG:​RASGRP1@Plasma Membrane map + Ca2+@Cytoplasm map → map Ca2+:​DAG:​RASGRP1@Plasma Membrane map
  16. Ca2+:​DAG:​RASGRP1@Plasma Membrane map → map Ca2+:​DAG:​RASGRP1@Golgi Apparatus map
  17. RAF1@Cytoplasm map + Ca2+:​DAG:​RAS*|​pho:​RASGRP1@Golgi Apparatus map → map Ca2+:​DAG:​RAF1|​pho:​RAS*|​pho:​RASGRP1@Golgi Apparatus map
  18. PI4,5-P2@Cytoplasm map → map DAG@Cytoplasm map + IP3@Cytoplasm map
As Catalyser:
  1. CARD11@T_cell map → map CARD11|​pho|​active@T_cell map
  2. GDP:​HRAS@T_cell map + GTP@T_cell map → map (GTP:​HRAS)|​active@T_cell map + GDP@T_cell map
  3. STK39@T_cell map → map STK39|​pho|​active@T_cell map
  4. PIP3*:​TEC@T_cell map → map (PIP3*:​TEC|​pho)|​active@T_cell map
  5. TAB*@T_cell map + MAP3K7@T_cell map → map MAP3K7:​TAB*|​pho@T_cell map
  6. BAD@T_cell map → map BAD|​pho@T_cell map
  7. gIRF9@INNATE_IMMUNE_CELL_Cytosol map → map rIRF9@INNATE_IMMUNE_CELL_Cytosol map
  8. NFAT*|​pho@INNATE_IMMUNE_CELL_Cytosol map → map NFAT*@INNATE_IMMUNE_CELL_Cytosol map
  9. STAT1@INNATE_IMMUNE_CELL_Cytosol map → map STAT1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  10. WASP*|​pho:​WIPF1@INNATE_IMMUNE_CELL_Cytosol map → map WASP*|​pho:​WIPF1|​pho@INNATE_IMMUNE_CELL_Cytosol map
  11. rGZMB@INNATE_IMMUNE_CELL_Cytosol map → map GZMB@SECRETORY_GRANULE map
  12. rGZMA@INNATE_IMMUNE_CELL_Cytosol map → map GZMA@SECRETORY_GRANULE map
  13. GRB2:​SOS*@Cytoplasm map + RTK*@Plasma Membrane map → map GRB2:​RTK*:​SOS*@Plasma Membrane map
  14. RAF1@Cytoplasm map → map RAF1|​pho@Cytoplasm map
  15. RTK*@Plasma Membrane map + SRC@Cytoplasm map → map RTK*:​SRC@Plasma Membrane map
  16. ERK*:​MEK*:​SEF*@Golgi Apparatus map → map ERK*|​pho|​pho:​MEK*|​pho|​pho:​SEF*@Cytoplasm map
  17. PKC*@Cytoplasm map → map PKC*@Cytoplasm map