Identifiers
HUGO:SOS1 HUGO:SOS2
HUGO:SOS1 HGNC:11187 ENTREZ:6654 UNIPROT:Q07889 GENECARDS:SOS1 HUGO:SOS2 HGNC:11188 ENTREZ:6655 UNIPROT:Q07890 GENECARDS:SOS2
SOS Ras/Rac guanine nucleotide exchange factor 1
HUGO:SOS1 hgnc_id:HGNC:11187 HGNC:11187 ENTREZ:6654 UNIPROT:Q07889
SOS Ras/Rho guanine nucleotide exchange factor 2
HUGO:SOS2 hgnc_id:HGNC:11188 HGNC:11188 ENTREZ:6655 UNIPROT:Q07890
son of sevenless homolog 1 (Drosophila)
HUGO:SOS1, HGNC:11187, ENTREZ:6654, UNIPROT:Q07889 , GENECARDS:GC02M039208
son of sevenless homolog 2 (Drosophila)
HUGO:SOS2, HGNC:11188, ENTREZ:6655, UNIPROT:Q07890, GENECARDS:GC14M050583
GINGF "gingival fibromatosis hereditary 1"
HUGO:SOS1 HGNC:11187 ENTREZ:6654 UNIPROT:Q07889
"son of sevenless (Drosophilia) homolog 2"
HUGO:SOS2 HGNC:11188 ENTREZ:6655 UNIPROT:Q07890
HUGO:SOS1 HGNC:11187 ENTREZ:6654 UNIPROT:Q07889 GENECARDS:SOS1 REACTOME:64848 KEGG:6654 ATLASONC:GC_SOS1 WIKI:SOS1
HUGO:SOS2 HGNC:11188 ENTREZ:6655 UNIPROT:Q07890 GENECARDS:SOS2 REACTOME:64850 ATLASONC:GC_SOS2 WIKI:SOS2
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / TCR_SIGNALING
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / CORE
EMT Senescence / EMT_REGULATORS
Innate Immunity / IMMUNOSTIMULATORY_CORE_PATHWAYS
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / MAPK
Survival / PI3K_AKT_MTOR
References
PMID:16102570 PMID:7510700 PMID:24027568
CASCADE:FGF
CASCADE:EGFR
GASCADE:IGF1R
PMID:15863030
GRB2 forms a complex with SOS protein and activate it downstream of FGF signaling
PMID:10567412; PMID:15567848
EGFR activates ERK via GRB2/SOS/RAS/RAF pathway
PMID:17673906
SHC1 gene has 3 corresponding protein isoforms: p66, p52 and p46
Upon TGFB stimulation, the activated TGFBR1 recruits and directly phosphorylates SHC1 (p66 or p52) on tyrosine and serine.
TGFB-induced SHC1 phosphorylation induces SHC1 (p66 or p52) association with Grb2 and Sos
SOS is an GTP-exchange factor for Ras
son of sevenless homolog 1 (Drosophila)
REACTOME:64848 KEGG:6654 ATLASONC:GC_SOS1 WIKI:SOS1
son of sevenless homolog 2 (Drosophila)
REACTOME:64850 ATLASONC:GC_SOS2 WIKI:SOS2
GINGF "gingival fibromatosis hereditary 1"
"son of sevenless (Drosophilia) homolog 2"
NATURAL_KILLER
CASCADE:Fc_gamma_RIII
PMID:8551221
CD16 and IL-2R Triggering Activate p21RAS in Human NK Cells via LAT/SHC/GRB2/sos pathway.
Phosphorylated Shc interacts with Grb2, which, in turn, interacts with Sos.
Sos is recruited from the cytosol to the plasma membrane as a result of its constitutive interaction with Grb2. It is in an autoinhibited state.
PMID:17496910
PMID:15574420
PMID:11777939
References
su_mpk1_mpk1_re286( Survival ):
Sos is recruited from the cytosol to the plasma membrane as a result of its constitutive interaction with Grb2. It is in an autoinhibited state.
PMID:17496910
→ SOS*@T_cell
→ GRB2:SHC1:SOS*@Cytosol
→ SOS*@Cytosol
→ SOS*@Cytosol
+ SOS*@Cytosol + SHC1@Cytosol → GRB2:SHC1:SOS*@Cytosol
→ SOS*@Cytosol
→ SOS1@Cytosol
→ SOS2@Cytosol
+ em_s2285 + SOS*@Cytosol + GRB2@Cytosol → EGFR family*|pho|hm2:SHC1_p66_p52*|Y_pho|S_pho@Cytosol
+ FGFR2|hm2|active@Cytosol + GRB2@Cytosol + SOS*@Cytosol → FGFR family*:FRS2|pho@Cytosol
→ SOS*@INNATE_IMMUNE_CELL_Cytosol
→ RAS activation@Cytoplasm
+ GRB2:SOS*@Cytoplasm + PI3,4,5-P3@Lipid Raft + RTK*@Cytoplasm + GF@default + RAS*@Cytoplasm + GAB1|Y977_pho|Y989_pho@Cytoplasm → GAB1|Y977_pho|Y989_pho:GF:GRB2:PI3,4,5-P3:RAS*:RTK*|pho|pho|hm2:SOS*:p110*:p85*@Lipid Raft
→ Ubiquitination@Cytoplasm
→ GAB1:GF:GRB2:PI3,4,5-P3:RAS*:RTK*|pho|pho|hm2:SOS*:p110*:p85*@Endosome
+ GRB2:RAS*|pho:RTK*:SOS*@Plasma Membrane → GRB2:RAF1|pho:RAS*|pho:RTK*:SOS*@Plasma Membrane
→ GRB2:RAS*|pho:RTK*:SOS*@Plasma Membrane + RAF1|pho@Mitochondria
+ BRAF@Cytoplasm → BRAF|pho:GRB2:RAS*|pho:RTK*:SOS*@Plasma Membrane
+ MAP3K1@Cytoplasm → GRB2:MAP3K1|pho:RAS*|pho:RTK*:SOS*@Cytoplasm
+ MAP3K2_3*@Cytoplasm → GRB2:MAP3K2_3*|pho:RAS*|pho:RTK*:SOS*@Cytoplasm
+ RAC1@Plasma Membrane → GRB2:RAC1|pho:RTK*:SOS*@Plasma Membrane
+ KSR1:MEK*@Cytoplasm → BRAF|pho:GRB2:KSR1:MEK*|pho|pho:RAS*|pho:RTK*:SOS*@Plasma Membrane
→ RAC1@Plasma Membrane + GRB2:RTK*:SOS*@Plasma Membrane
+ MAP3K10_11*@Cytoplasm → GRB2:MAP3K10_11*|pho:RAC1|pho:RTK*:SOS*@Cytoplasm
+ ERK*@Cytoplasm → BRAF|pho:ERK*|pho|pho:GRB2:KSR1:MEK*|pho|pho:RAS*|pho:RTK*:SOS*@Plasma Membrane
+ LAMTOR2:MEK*:MP1*@Late Endosomes → GRB2:LAMTOR2:MEK*:MP1*:RAS*|pho:RTK*:SOS*@Late Endosomes
→ GRB2:LAMTOR2:MEK*:MP1*:RAS*|pho:RTK*:SOS*@Late Endosomes + ERK*@Cytoplasm + RAF1@Cytoplasm
+ GRB2:LAMTOR2:MEK*:MP1*:RAS*|pho:RTK*:SOS*@Late Endosomes → GRB2:LAMTOR2:MEK*|pho|pho:MP1*:RAF1|pho:RAS*|pho:RTK*:SOS*@Late Endosomes
+ GRB2:LAMTOR2:MEK*|pho|pho:MP1*:RAF1|pho:RAS*|pho:RTK*:SOS*@Late Endosomes → ERK*|pho|pho:GRB2:LAMTOR2:MEK*|pho|pho:MP1*:RAF1|pho:RAS*|pho:RTK*:SOS*@Late Endosomes
+ RTK*@Plasma Membrane → GRB2:RTK*:SOS*@Plasma Membrane
+ SOS*@Cytoplasm → GRB2:SOS*@Cytoplasm
→ KSR1:MEK*@Cytoplasm + BRAF|pho:GRB2:RAS*|pho:RTK*:SOS*@Plasma Membrane + ERK*|pho|pho@Cytoplasm
→ BRAF|pho:GRB2:KSR1-NTER*:RAS*|pho:RTK*:SOS*@Plasma Membrane + KSR1-CTER*:MEK*@Cytoplasm
→ GRB2:LAMTOR2:MEK*|pho|pho:MP1*:RAF1|pho:RAS*|pho:RTK*:SOS*@Late Endosomes + ERK*|pho|pho@Cytoplasm
→ RAS*@Plasma Membrane + GRB2:RTK*:SOS*@Plasma Membrane
→ ERK*|pho|pho:KSR1:MEK*|pho|pho@Cytoplasm + BRAF|pho:GRB2:RAS*|pho:RTK*:SOS*@Plasma Membrane
+ GRB2:RTK*:SOS*@Plasma Membrane → GRB2:RAS*|pho:RTK*:SOS*@Plasma Membrane
+ GTP@T_cell → (GTP:HRAS)|active@T_cell + GDP@T_cell
→ GTP:RAS*@Cytosol
+ GTP@Cytosol → GTP:RAS*@Cytosol + GDP@Cytosol
+ GTP@INNATE_IMMUNE_CELL_Cytosol → GTP:HRAS@INNATE_IMMUNE_CELL_Cytosol + GDP@INNATE_IMMUNE_CELL_Cytosol
→ PI3,4,5-P3@Lipid Raft
→ MAP2K4|pho|pho@Cytoplasm
→ MAP2K7|pho|pho@Cytoplasm
→ MAP2K6|pho|pho@Cytoplasm
→ MEK*|pho|pho@Cytoplasm
→ FRS2|pho@Plasma Membrane
→ IMP*@Cytoplasm + KSR1:MEK*@Cytoplasm