Simple molecule PI3,4,5-P3 map
PI3,4,5-P3@Lipid Raft

Identifiers
phosphatidylinositol-3,4,5-triphosphate
CAS:N/A PUBCHEM:8260 CHEBI:16618 KEGGCOMPOUND:C05981

Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / PI3K_AKT_MTOR  map

References
s_akt1_re3( Survival  map ):
PMID:15534002
PMID:9779982
PMID:14585353
s_akt1_re4( Survival  map ):
PMID:12040186
PMID:16288286
s_akt1_re7( Survival  map ):
PMID:18802401
PMID:17680028
s_akt1_re11( Survival  map ):
PMID:15584861
PMID:10648629
s_akt1_re115( Survival  map ):
PMID:12791379
PMID:10582334

PI3,4,5-P3@Cytosol

Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / HEDGEHOG  map

PI3,4,5-P3@Cytosol

Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / HEDGEHOG  map

Modifications:
In compartment: Cytosol
  1. PI3,4,5-P3@Cytosol map
  2. PI3,4,5-P3@Cytosol map
In compartment: Lipid Raft
  1. PI3,4,5-P3@Lipid Raft map
Participates in complexes:
In compartment: Cytosol
  1. PI3,4,5-P3:​PREX*@Cytosol map
  2. PI3,4,5-P3:​TIAM1@Cytosol map
  3. AKT*|​pho|​pho:​PI3,4,5-P3@Cytosol map
  4. AKT*|​pho|​pho|​pho:​PI3,4,5-P3@Cytosol map
In compartment: Endosome
  1. GAB1:​GF:​GRB2:​PI3,4,5-P3:​RAS*:​RTK*|​pho|​pho|​hm2:​SOS*:​p110*:​p85*@Endosome map
In compartment: Lipid Raft
  1. PDPK1|​S241_pho:​PI3,4,5-P3@Lipid Raft map
  2. AKT1|​T308_pho|​T450_pho|​S473_emp:​PI3,4,5-P3@Lipid Raft map
  3. AKT1|​T308_pho|​T450_pho|​S473_pho:​PI3,4,5-P3@Lipid Raft map
  4. GAB1|​Y977_pho|​Y989_pho:​GF:​GRB2:​PI3,4,5-P3:​RAS*:​RTK*|​pho|​pho|​hm2:​SOS*:​p110*:​p85*@Lipid Raft map
Participates in reactions:
As Reactant or Product:
  1. AKT1|​T308_pho|​T450_pho|​S473_pho:​PI3,4,5-P3@Lipid Raft map → map AKT1|​T308_pho|​T450_pho|​S473_pho|​active@Nucleus map
  2. p110*:​p85*@Cytoplasm map + GRB2:​SOS*@Cytoplasm map + PI3,4,5-P3@Lipid Raft map + RTK*@Cytoplasm map + GF@default map + RAS*@Cytoplasm map + GAB1|​Y977_pho|​Y989_pho@Cytoplasm map → map GAB1|​Y977_pho|​Y989_pho:​GF:​GRB2:​PI3,4,5-P3:​RAS*:​RTK*|​pho|​pho|​hm2:​SOS*:​p110*:​p85*@Lipid Raft map
  3. PI3,4,5-P3@Lipid Raft map → map PI3,4-P2@Lipid Raft map
  4. AKT1|​T308_pho|​T450_pho|​S473_pho:​PI3,4,5-P3@Lipid Raft map → map AKT1|​T308_pho|​T450_pho|​S473_emp:​PI3,4,5-P3@Lipid Raft map
  5. GAB1:​GF:​GRB2:​PI3,4,5-P3:​RAS*:​RTK*|​pho|​pho|​hm2:​SOS*:​p110*:​p85*@Endosome map → map Ubiquitination@Cytoplasm map
  6. GAB1|​Y977_pho|​Y989_pho:​GF:​GRB2:​PI3,4,5-P3:​RAS*:​RTK*|​pho|​pho|​hm2:​SOS*:​p110*:​p85*@Lipid Raft map → map GAB1:​GF:​GRB2:​PI3,4,5-P3:​RAS*:​RTK*|​pho|​pho|​hm2:​SOS*:​p110*:​p85*@Endosome map
  7. PI3,4,5-P3@Lipid Raft map + AKT1|​T450_pho|​S473_emp|​active@Cytoplasm map → map AKT1|​T308_pho|​T450_pho|​S473_emp:​PI3,4,5-P3@Lipid Raft map
  8. AKT1|​T308_pho|​T450_pho|​S473_emp:​PI3,4,5-P3@Lipid Raft map → map AKT1|​T308_pho|​T450_pho|​S473_pho:​PI3,4,5-P3@Lipid Raft map
  9. AKT1|​T308_pho|​T450_pho|​S473_emp:​PI3,4,5-P3@Lipid Raft map → map AKT1|​T450_pho|​S473_emp|​active@Cytoplasm map
  10. PtdIns(4,5)-P2@Lipid Raft map → map PI3,4,5-P3@Lipid Raft map
  11. PI3,4,5-P3@Lipid Raft map → map PtdIns(4,5)-P2@Lipid Raft map
  12. AKT1|​T450_emp|​S473_emp|​S129_pho:​HSP90*@Cytoplasm map → map AKT1|​T308_pho|​T450_pho|​S473_pho:​PI3,4,5-P3@Lipid Raft map
  13. PI3,4,5-P3@Lipid Raft map + PDPK1@Lipid Raft map → map PDPK1|​S241_pho:​PI3,4,5-P3@Lipid Raft map
  14. AKT*|​pho|​pho:​PI3,4,5-P3@Cytosol map → map AKT*|​pho|​pho|​pho:​PI3,4,5-P3@Cytosol map
  15. PI3K AKT MTOR pathway@Cytosol map → map AKT*|​pho|​pho:​PI3,4,5-P3@Cytosol map
  16. PI3K AKT MTOR pathway@Cytosol map → map PI3,4,5-P3@Cytosol map
  17. PI3,4,5-P3@Cytosol map + TIAM1@Cytosol map → map PI3,4,5-P3:​TIAM1@Cytosol map
  18. PI3,4,5-P3@Cytosol map + PREX*@Cytosol map → map PI3,4,5-P3:​PREX*@Cytosol map
As Catalyser:
  1. GSK3_beta_*@Cytoplasm map → map GSK3_beta_*|​pho@Cytoplasm map
  2. MDM2|​S166_emp@Cytoplasm map → map MDM2|​S166_pho|​pho@Cytoplasm map
  3. su_akt1_s_akt1_s533 → map su_akt1_s_akt1_s528
  4. 14-3-3*:​BAD|​S112_pho|​S136_pho@Mitochondria map → map 14-3-3*:​BAD|​S112_pho|​S136_pho|​S155_pho@Mitochondria map
  5. ENOS*@Cytoplasm map → map ENOS*|​pho@Cytoplasm map
  6. Caspase9*@Cytoplasm map → map Caspase9*|​pho@Cytoplasm map
  7. p21CIP1*@Cytoplasm map → map p21CIP1*|​T145_pho@Cytoplasm map
  8. p21CIP1*|​T145_pho@Cytoplasm map → map p21CIP1*|​T145_pho|​T146_pho@Cytoplasm map
  9. CUL1:​RBX1:​RICTOR@Cytoplasm map → map CUL1:​RBX1:​RICTOR|​T1135_pho@Cytoplasm map
  10. PI3,4,5-P3@Lipid Raft map + AKT1|​T450_pho|​S473_emp|​active@Cytoplasm map → map AKT1|​T308_pho|​T450_pho|​S473_emp:​PI3,4,5-P3@Lipid Raft map
  11. AKT1|​T308_pho|​T450_pho|​S473_emp:​PI3,4,5-P3@Lipid Raft map → map AKT1|​T308_pho|​T450_pho|​S473_pho:​PI3,4,5-P3@Lipid Raft map
  12. PtdIns(4,5)-P2@Lipid Raft map → map PI3,4,5-P3@Lipid Raft map
  13. TSC1:​TSC2@Endosome Membrane map → map TSC1:​TSC2|​S981_pho|​S1130_pho|​pho|​S1132_pho|​pho|​S1088_pho|​S1086_pho@Endosome Membrane map
  14. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome map → map MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome map
  15. p27KIP1*|​S10_pho@Cytoplasm map → map p27KIP1*|​S10_pho|​T187_emp|​pho|​pho@Cytoplasm map
  16. AKAP*:​PKA*@Primary Cilium map → map PKA*@Primary Cilium map + AKAP*@Primary Cilium map
  17. GSK3_beta_*@Cytosol map → map GSK3_beta_*|​pho|​active@Cytosol map
  18. GDP:​RAC1@Cytosol map + GTP@Cytosol map → map GTP:​RAC1@Cytosol map + GDP@Cytosol map