Identifiers
NAME:p110*:p85*
Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / HEDGEHOG
References
s_shh3_re15( Survival ):
PMID:11801735
PMID:19082481
s_akt1_re11( Survival ):
PMID:15584861
PMID:10648629
Identifiers
NAME:p110*:p85*
Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / PI3K_AKT_MTOR
References
PMID:16847462
Class IA PI3K is a heterodimer that consists of a p85 regulatory subunit and a p110 catalytic subunit. Three genes PIK3R1 PIK3R2 and PIK3R3 encode the p85?? p85?? and p55?? isoforms of the p85 regulatory subunit respectively. The PIK3R1 gene also gives rise to two shorter isoforms p55?? and p50?? through alternative transcription-initiation sites. The class IA p85 regulatory isoforms have a common core structure consisting of a p110-binding domain (also called the inter-SH2 domain) flanked by two Src-homology 2 (SH2) domains. The two longer isoforms p85?? and p85?? also have an extended N-terminal region (dashed outline) containing an Src-homology 3 (SH3) domain and a BCR homology (BH) domain flanked by two proline-rich (P) regions.
PMID:19568798
PI3-Ks can be activated through several mechanisms. The SH2 domains in the p85 regulatory subunit of class Ia PI3- Ks have a high affinity for phosphorylated tyrosine residues found in activated growth factor RTKs and binding of the regulatory subunit to this motif activates PI3-KPhosphoinositide-3-kinase class I a
Identifiers_end
s_akt1_re2( Survival ):
PMID:12040186
PMID:14585353
s_akt1_re6( Survival ):
PMID:15534002
PMID:9779982
su_akt1_s_akt1_re2( Survival ):
su_akt1_s_akt1_re6( Survival ):
+ GRB2:SOS*@Cytoplasm + PI3,4,5-P3@Lipid Raft + RTK*@Cytoplasm + GF@default + RAS*@Cytoplasm + GAB1|Y977_pho|Y989_pho@Cytoplasm → GAB1|Y977_pho|Y989_pho:GF:GRB2:PI3,4,5-P3:RAS*:RTK*|pho|pho|hm2:SOS*:p110*:p85*@Lipid Raft
+ p110*:p85*@Cytoplasm → GF:RTK*|pho|pho|hm2:p110*:p85*@Lipid Raft
+ RAS*@Cytoplasm → RAS*:p110*:p85*@Lipid Raft
+ p110*:p85*@Cytosol → C-FES*|Y713_pho|Y811_pho|hm2:p110*:p85*@Cytosol