Protein CXCL8 map

Identifiers
HUGO:CXCL8 HGNC:6025
HUGO:CXCL8
C-X-C motif chemokine ligand 8
HUGO:CXCL8 hgnc_id:HGNC:6025 HGNC:6025 ENTREZ:3576 UNIPROT:P10145

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / TCR_SIGNALING  map
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / CYTOKINES_CHEMOKINES_PRODUCTION  map
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / SENESCENCE  map

References
PMID:25922287
PMID:15079071 PMID:27557510
CASCADE:IL1
CASCADE:TNF
PMID:21847358
IL-1?? was established as the initiator of the enhanced production of inflammatory factors through the binding of IL-1?? to IL-1 receptor 1 (IL-1R1) expressed predominantly by CAFs.
IL1A upregulates expression of IL6, CCL20, CXCL8, COX2 in CAFs.
IL-1?? Expression Levels in prostate cancer Tissue Correlated to Poor Clinical Outcome
PMID:17916596
In vitro analyses
revealed a striking induction of IL-8 expression in CAFs
and LFs by tumor necrosis factor-alpha (TNFA). The effect
of TNFA on CAFs is inhibited by the nuclear factor-kB
inhibitor parthenolide.
PMID:24406209
CXCL8 expressed by CAFs is involved in the recruitment of neutrophils.
PMID:26201938
The expression levels of cytokine genes, including those for IL6, CXCL8, TNF, TGFB1, and VEGFA, were higher in CAFs. T cell proliferation was suppressed more by CAFs or their supernatants than by NFs.
PMID:17784835
IL8 expression is dependent of NF-_kappa_B_ activity
PMID??:??26548401
miR-302c was found to inhibit IL-8 expression and restrain tumor invasion and metastasis.
PMID:18555778
In response to oncogenic stress, both IL6 and IL8 genes were activatedbythe transcription factorC/EBPb,upon its recruitment to either promoter.

CXCL8@Extracellular space

References
em_re1535( EMT Senescence  map ):
PMID:17784835
IL8 expression is dependent of NF-_kappa_B_ activity
em_re1578( EMT Senescence  map ):
PMID??:??26548401
miR-302c was found to inhibit IL-8 expression and restrain tumor invasion and metastasis.

Modifications:
In compartment: Cytosol
  1. CXCL8@Cytosol map
In compartment: Extracellular Matrix
  1. CXCL8@Extracellular Matrix map
In compartment: Extracellular space
  1. CXCL8@Extracellular space map
In compartment: T_cell
  1. CXCL8@T_cell map
Participates in complexes:
In compartment: Cytosol
  1. CXCL8:​CXCR1@Cytosol map
  2. CXCL8:​CXCR2@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. rCXCL8@T_cell map → map CXCL8@T_cell map
  2. CXCL8@Cytosol map → map CXCL8@Extracellular Matrix map
  3. CXCL8@Cytosol map → map CYTOKINE_CHEMOKINE_PRODUCTION@default map
  4. rCXCL8@Cytosol map → map CXCL8@Cytosol map
  5. NF-_kappa_B pathway@Cytosol map → map CXCL8@Extracellular space map
  6. CXCL8@Extracellular space map → map Senescence@Cytosol map
  7. CXCL8@Extracellular space map + CXCR2@Cytosol map → map CXCL8:​CXCR2@Cytosol map
  8. CXCR1@Cytosol map + CXCL8@Extracellular space map → map CXCL8:​CXCR1@Cytosol map
  9. rCXCL8@Nucleus map → map CXCL8@Extracellular space map
As Catalyser: