Complex BRAF:ERK*:GRB2:KSR1:MEK*:RAS*:RTK*:SOS*
Complex composition:
- GRB2
- SOS*
- KSR1
- RTK*
- ERK*
- MEK*
- BRAF
- RAS*
BRAF|pho:ERK*|pho|pho:GRB2:KSR1:MEK*|pho|pho:RAS*|pho:RTK*:SOS*@Plasma Membrane
Identifiers
NAME:BRAF:ERK*:GRB2:KSR1:MEK*:RAS*:RTK*:SOS*
References
su_mpk1_mpk1_re16( Survival
):
ERK recruitment is enhanced by KSR1. ERK is then phosphorylated by MEK.
PMID:19541618
su_mpk1_mpk1_re29( Survival
):
Docking of activated ERK to the KSR1 scaffold negatively regulates the interaction between KSR1 and B-Raf.
Modifications:
Participates in complexes:
In compartment: Plasma Membrane
- BRAF|pho:ERK*|pho|pho:GRB2:KSR1:MEK*|pho|pho:RAS*|pho:RTK*:SOS*@Plasma Membrane
Participates in reactions:
As Reactant or Product:- BRAF|pho:GRB2:KSR1:MEK*|pho|pho:RAS*|pho:RTK*:SOS*@Plasma Membrane
+ ERK*@Cytoplasm
→
BRAF|pho:ERK*|pho|pho:GRB2:KSR1:MEK*|pho|pho:RAS*|pho:RTK*:SOS*@Plasma Membrane
- BRAF|pho:ERK*|pho|pho:GRB2:KSR1:MEK*|pho|pho:RAS*|pho:RTK*:SOS*@Plasma Membrane
→
KSR1:MEK*@Cytoplasm
+ BRAF|pho:GRB2:RAS*|pho:RTK*:SOS*@Plasma Membrane
+ ERK*|pho|pho@Cytoplasm
- BRAF|pho:ERK*|pho|pho:GRB2:KSR1:MEK*|pho|pho:RAS*|pho:RTK*:SOS*@Plasma Membrane
→
ERK*|pho|pho:KSR1:MEK*|pho|pho@Cytoplasm
+ BRAF|pho:GRB2:RAS*|pho:RTK*:SOS*@Plasma Membrane
As Catalyser: