RTK*

Protein RTK*

Identifiers
HUGO:EGFR HUGO:ERBB2 HUGO:ERBB3 HUGO:ERBB4 HUGO:FGFR1 HUGO:FGFR2 HUGO:FGFR3 HUGO:FGFR4 HUGO:FLT1 HUGO:FLT3 HUGO:FLT4 HUGO:PDGFRA HUGO:PDGFRB HUGO:IGF1R HUGO:EPHA1 HUGO:RTKN
Receptor tyrosine kinase
epidermal growth factor receptor
"epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB
HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian)
NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)"
HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
LCCS2 "lethal congenital contracture syndrome 2"
HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
"v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4"
HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303
fibroblast growth factor receptor 1
FLT2 "fms-related tyrosine kinase 2" KAL2
HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362
fibroblast growth factor receptor 2
"bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR
HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802
fibroblast growth factor receptor 3
ACH "achondroplasia thanatophoric dwarfism"
HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607
fibroblast growth factor receptor 4
HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455
fms-related tyrosine kinase 1
FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)"
HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948
fms-related tyrosine kinase 3
HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888
fms-related tyrosine kinase 4
HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916
platelet-derived growth factor receptor alpha polypeptide
HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234
platelet-derived growth factor receptor beta polypeptide
HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
HUGO:KIT HGNC:6342 ENTREZ:3815 UNIPROT:P10721
insulin-like growth factor 1 receptor
HUGO:IGF1R HGNC:5465 ENTREZ:3480 UNIPROT:P08069
met proto-oncogene
synonym "hepatocyte growth factor receptor", HGFR
HUGO:MET HGNC:7029 ENTREZ:4233 UNIPROT:P08581
EPH receptor A1
HUGO:EPHA1 HGNC:3385 ENTREZ:2041 UNIPROT:P21709
EPH receptor A2
HUGO:EPHA2 HGNC:3386 ENTREZ:1969 UNIPROT:P29317
EPH receptor B1
HUGO:EPHB1 HGNC:3392 ENTREZ:2047 UNIPROT:P54762
EPH receptor B2
HUGO:EPHB2 HGNC:3393 ENTREZ:2048 UNIPROT:P29323
PDGFR
HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR
HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2
HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3
HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4
HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1
HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2
HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3
HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4
HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1
HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3
HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4
HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA
HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB
A generic name for this family of receptors that contain a tyrosine kinase activity.
rhotekin
HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / ECM
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / MAPK
Survival / PI3K_AKT_MTOR
Survival / WNT_NON_CANONICAL

References
RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated.
PMID:17496910
PMID:12040186
PMID:19568798
PMID:14585353
RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase)

RTK*@Cytosol

References
mo_re186:( motility ) PMID:26597054

RTK*@Plasma Membrane

References
su_mpk1_mpk1_re25( Survival ):
Grb2 is recruited to the plasma membrane by activated RTKs.
Recruitment to the membrane and tyrosine phosphorylation enhance the enzymatic activity of PLC-g leading to the formation of two second messengers diacylglycerol (DAG) and inositol 145-trisphosphate (IP3). IP3 releases Ca2+ from internal stores which in turn acts in concert with DAG to translocate protein kinase C (PKC) to the cell membrane and stimulate its enzymatic activity.
FGF stimulation leads to phosphorylation of Shp2 on a tyrosine residue that forms a complex with an additional molecule of Grb2. Grb2/Sos complexes are thus recruited directly and indirectly via Shp2 upon tyrosine phosphorylation of FRS2a in response to growth factor stimulation.
PKC may cause phosphorylation of EGFR leading to a decrease in its activity.
PMID:17496910 PMID:15567848 PMID:11447289 PMID:6321473
su_mpk1_mpk1_re40( Survival ):
In addition to Grb2/SOS PLCG and SRC are also recruited to activated PTKRs at the PM.
Activation of the TCR results in tyrosine phosphorylation of the ?? chain of the receptor by Src family kinases and the resulting phosphotyrosines serve to recruit ZAP-70 (not modelled) that in turn phosphorylates the scaffold protein LAT (not modelled) at multiple sites.
PMID:19615955 PMID:16488589 PMID:15567848
su_mpk1_mpk1_re272( Survival ):
EGF and FGF can induce cell cycle arrest through activation of STAT1 transcription factor.
PMID:15567848
su_mpk1_mpk1_re273( Survival ):
FGF-induced tyrosine phosphorylation of FRS2 results in complex formation with the adaptor protein Grb2 bound to Cbl by means of its SH3 domains. FGF-induced ternary complex formation among FRS2 Grb2 and Cbl results in ubiquitination and degradation of FRS2 and FGF receptor (FGFR).
Spry is induced by activated ERK through phosphorylation on Tyr55. It positively regulates EGFR signalling by sequestering Cbl whereas it negatively regulates FGFR signalling by sequestering Grb2 from FSR2.
PMID:11447289 PMID:11997436 PMID:15173823
su_mpk1_mpk1_re284( Survival ):
Grb2 recruits the docking protein Gab1 which is tyrosine phosphorylated by EGFR or FGFR leading to recruitment and activation of the PI3K-Akt cell survival pathway.
Recruitment of PI 3-kinase by Gab1 results in a positive-feedback loop mediated by binding of the PH domain of Gab1 to the product of PI3-kinase activation phosphatidylinositol-345-triphosphate.
PMID:15567848 PMID:15199124

RTK*@Cytoplasm

References
s_akt1_re11( Survival ):
PMID:15584861
PMID:10648629

Modifications:
In compartment: Cytoplasm

RTK*@Cytoplasm
RTK*@Cytoplasm

In compartment: Cytosol

RTK*@Cytosol
RTK*|hm2|active@Cytosol

In compartment: Plasma Membrane

RTK*@Plasma Membrane

Participates in complexes:
In compartment: Cytoplasm

In compartment: Cytosol

GF:RTK*|pho|pho@Cytosol

In compartment: Endosome

In compartment: Late Endosomes

In compartment: Lipid Raft

In compartment: Plasma Membrane

Participates in reactions:
As Reactant or Product:

As Catalyser: