Reaction dissociation su_mpk1_mpk1_re193 map

ERK*|​pho|​pho:​GRB2:​LAMTOR2:​MEK*|​pho|​pho:​MP1*:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map → GRB2:​LAMTOR2:​MEK*:​MP1*:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map + ERK*@Cytoplasm map + RAF1@Cytoplasm map

Reaction regulators:
Catalysis
  1. su_mpk1_mpk1_s1050
  2. su_mpk1_mpk1_s1051
  3. su_mpk1_mpk1_s1052
  4. p38*|​pho|​pho@Cytoplasm map
  5. PP2A_C*|​unk@Cytoplasm map


References
MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. A direct interaction between P38 and ERK has been proposed as a mechanism to inhibit ERK phosphorylation. AP-1 mediated gene expression inhibits ERK phosphorylation.
PMID:18039929