Reaction state_transition su_mpk1_mpk1_re284 map

GAB1:​GRB2@Cytoplasm map → GAB1|​pho:​GRB2@Cytoplasm map

Reaction regulators:
Catalysis
  1. RTK*@Plasma Membrane map
  2. p110*|​pho@Cytoplasm map


References
Grb2 recruits the docking protein Gab1 which is tyrosine phosphorylated by EGFR or FGFR leading to recruitment and activation of the PI3K-Akt cell survival pathway.
Recruitment of PI 3-kinase by Gab1 results in a positive-feedback loop mediated by binding of the PH domain of Gab1 to the product of PI3-kinase activation phosphatidylinositol-345-triphosphate.
PMID:15567848 PMID:15199124