Simple molecule PIP2*
PIP2*@T_cell
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response
/ TCR_SIGNALING
References
PMID:12040186 PMID:12393695
PIP2*@Cytosol
References
PMID:12040186
The activated PI3K converts the plasma membrane lipid phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] to phosphatidylinositol-3,4,5-trisphosphate [PI(3,4,5)P3].
PMID:12393695
SHIP1 inhinits NK cells activation via bloking of PI3K pathway. It hydrolyzes the 5???-phosphate of PI3,4,5P3l eading to its conversion to PI3,4P2.
PIP2*@INNATE_IMMUNE_CELL_Cytosol
References
PMID:12040186
The activated PI3K converts the plasma membrane lipid phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] to phosphatidylinositol-3,4,5-trisphosphate [PI(3,4,5)P3].
PMID:12393695
SHIP1 inhinits NK cells activation via bloking of PI3K pathway. It hydrolyzes the 5???-phosphate of PI3,4,5P3l eading to its conversion to PI3,4P2.
Modifications:
In compartment: Cytosol
- PIP2*@Cytosol
In compartment: INNATE_IMMUNE_CELL_Cytosol
- PIP2*@INNATE_IMMUNE_CELL_Cytosol
In compartment: T_cell
- PIP2*@T_cell
Participates in complexes:
Participates in reactions:
As Reactant or Product:- PIP2*@T_cell
→
PIP3*@T_cell
- PIP3*@T_cell
→
PIP2*@T_cell
- PtdIns(4)-P@T_cell
→
PIP2*@T_cell
- PIP2*@T_cell
→
IP3@T_cell
+ DAG@T_cell
- PIP2*@Cytosol
→
PIP3*@Cytosol
- PIP3*@Cytosol
→
PIP2*@Cytosol
- PtdIns(4)-P@Cytosol
→
PIP2*@Cytosol
- PIP2*@INNATE_IMMUNE_CELL_Cytosol
→
PIP3*@INNATE_IMMUNE_CELL_Cytosol
- PIP3*@INNATE_IMMUNE_CELL_Cytosol
→
PIP2*@INNATE_IMMUNE_CELL_Cytosol
- PtdIns(4)-P@INNATE_IMMUNE_CELL_Cytosol
→
PIP2*@INNATE_IMMUNE_CELL_Cytosol
- PtdIns(4)-P@INNATE_IMMUNE_CELL_Cytosol
→
PIP2*@INNATE_IMMUNE_CELL_Cytosol
- PIP2*@Cytosol
→
PIP3*@Cytosol
- PIP3*@Cytosol
→
PIP2*@Cytosol
As Catalyser:- PSD4@INNATE_IMMUNE_CELL_Cytosol
→
PSD4@INNATE_IMMUNE_CELL_Cytosol