Protein FRS2 map

Identifiers
fibroblast growth factor receptor substrate 2
HUGO:FRS2 hgnc_id:HGNC:16971 HGNC:16971 ENTREZ:10818 UNIPROT:Q8WU20
HUGO:FRS2, HGNC:16971, ENTREZ:10818, UNIPROT:Q8WU20
HUGO:FRS2 HGNC:16971 ENTREZ:10818 UNIPROT:Q8WU20HUGO:FRS2

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / GROWTH_FACTORS_SIGNALING_PATHWAYS  map
 EMT Senescence  map  / EMT_REGULATORS  map

References
CASCADE:FGF
PMID:11447289
Experiments with FRS2 alpha-deficient fibroblasts demonstrate that FRS2 alpha plays a critical role in FGF-induced mitogen-activated protein (MAP) kinase stimulation, phosphatidylinositol-3 (PI-3) kinase activation, chemotactic response, and cell proliferation.
FRS2?? has been implicated as a critical link between FGF stimulation and the Ras/MAP kinase signaling pathway
PMID:17673906
Upon TGFB stimulation, the activated TGFBR1 recruits and directly phosphorylates SHC1 on tyrosine and serine.
TGFB-induced SHC1 phosphorylation induces SHC1 association with Grb2 and Sos
PMID:25772309

FRS2@Plasma Membrane

References
su_mpk1_mpk1_re273( Survival  map ):
FGF stimulation leads to phosphorylation of Shp2 on a tyrosine residue that forms a complex with an additional molecule of Grb2. Grb2/Sos complexes are thus recruited directly and indirectly via Shp2 upon tyrosine phosphorylation of FRS2a in response to growth factor stimulation.
FGF-induced tyrosine phosphorylation of FRS2 results in complex formation with the adaptor protein Grb2 bound to Cbl by means of its SH3 domains. FGF-induced ternary complex formation among FRS2 Grb2 and Cbl results in ubiquitination and degradation of FRS2 and FGF receptor (FGFR).
Spry is induced by activated ERK through phosphorylation on Tyr55. It positively regulates EGFR signalling by sequestering Cbl whereas it negatively regulates FGFR signalling by sequestering Grb2 from FSR2.
PMID:11447289 PMID:11997436 PMID:15173823

FRS2|​pho@Plasma Membrane

References
su_mpk1_mpk1_re273( Survival  map ):
FGF stimulation leads to phosphorylation of Shp2 on a tyrosine residue that forms a complex with an additional molecule of Grb2. Grb2/Sos complexes are thus recruited directly and indirectly via Shp2 upon tyrosine phosphorylation of FRS2a in response to growth factor stimulation.
FGF-induced tyrosine phosphorylation of FRS2 results in complex formation with the adaptor protein Grb2 bound to Cbl by means of its SH3 domains. FGF-induced ternary complex formation among FRS2 Grb2 and Cbl results in ubiquitination and degradation of FRS2 and FGF receptor (FGFR).
Spry is induced by activated ERK through phosphorylation on Tyr55. It positively regulates EGFR signalling by sequestering Cbl whereas it negatively regulates FGFR signalling by sequestering Grb2 from FSR2.
PMID:11447289 PMID:11997436 PMID:15173823
su_mpk1_mpk1_re25( Survival  map ):
Grb2 is recruited to the plasma membrane by activated RTKs.
Recruitment to the membrane and tyrosine phosphorylation enhance the enzymatic activity of PLC-g leading to the formation of two second messengers diacylglycerol (DAG) and inositol 145-trisphosphate (IP3). IP3 releases Ca2+ from internal stores which in turn acts in concert with DAG to translocate protein kinase C (PKC) to the cell membrane and stimulate its enzymatic activity.
PKC may cause phosphorylation of EGFR leading to a decrease in its activity.
PMID:17496910 PMID:15567848 PMID:11447289 PMID:6321473

Modifications:
In compartment: Cytosol
  1. FRS2@Cytosol map
  2. FRS2|​pho|​active@Cytosol map
In compartment: Membrane
  1. FRS2@Membrane map
  2. FRS2|​pho|​active@Membrane map
In compartment: Plasma Membrane
  1. FRS2@Plasma Membrane map
  2. FRS2|​pho@Plasma Membrane map
Participates in complexes:
In compartment: Cytosol
  1. FGFR family*:​FRS2|​pho@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. FRS2@Cytosol map → map FRS2|​pho|​active@Cytosol map
  2. FRS2|​pho|​active@Cytosol map → map MIGRATION_INTO_THE_TUMOR@default map
  3. FRS2@Cytosol map → map FRS2|​pho|​active@Cytosol map
  4. FRS2|​pho|​active@Cytosol map + FGFR2|​hm2|​active@Cytosol map + GRB2@Cytosol map + SOS*@Cytosol map → map FGFR family*:​FRS2|​pho@Cytosol map
  5. FRS2@Membrane map → map FRS2|​pho|​active@Membrane map
  6. FRS2|​pho|​active@Membrane map → map PI3K_PATHWAY@Membrane map
  7. FRS2|​pho|​active@Membrane map → map MAPK_PATHWAYS@Membrane map
  8. FRS2@Plasma Membrane map → map FRS2|​pho@Plasma Membrane map
As Catalyser:
  1. PTPN11@Cytosol map → map PTPN11|​pho@Cytosol map
  2. GRB2:​SOS*@Cytoplasm map + RTK*@Plasma Membrane map → map GRB2:​RTK*:​SOS*@Plasma Membrane map