Identifiers
HUGO:FYN
FYN oncogene related to SRC, FGR, YES
HUGO:FYN HGNC:4037 ENTREZ:2534 UNIPROT:P06241

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response   / SMAC 
 Adaptive Immune Response   / INHIBITING_CHECKPOINTS 
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence   / EMT_REGULATORS 
 EMT Senescence   / CYTOSKELETON_POLARITY 

References
PMID:21378271
PMID:19290918 PMID:9738502 PMID:12218089 PMID:10648627 PMID:27192565 PMID:22863785
 NATURAL_KILLER 
CASCADE:NKP44
CASCADE:NKP30
CASCADE:NKP46
CASCADE:SLAMF7
CASCADE:LFA1
CASCADE:INTEGRIN_A4B1
CASCADE:INTEGRIN_A5B1
PMID:12731048, PMID:20814939
Upon engagement of activating receptors, the tyrosine-containing adapters undergo tyrosine phosphorylation mediated by Src family kinases (SFKs)??.
Cross-linking of Nkp30 or Nkp46 or NKp44 resulted in strong tyrosine phosphorylation of LCK anf FYN kinases.
PMID:10591186, PMID:24440149
Cross-Linking of LFA-1 induces tyrosine Phosphorylation of DNAM-,FYN probably phosphorylates DNAM1 Y322 in NK cells
PMID:22683124
Fyn-deficient NK cells exhibited defective killing.
PMID:19909365
FYN is adaptor protein f Fc epsilon RI signaling in mast cells

References
in_re159( Innate Immunity  ):
PMID:11062502, PMID:15536084
ERK1/2 activation induces perforin and granzyme B movement towards target tumor cells downstream of PI3K signaling in NK cells.

1. FYN@Cytosol
2. FYN|​pho@Cytosol

1. FYN@INNATE_IMMUNE_CELL_Cytosol
2. FYN|​pho|​active@INNATE_IMMUNE_CELL_Cytosol

1. FYN@T_cell

1. FYN|​Y528_pho@cSMAC
2. FYN|​Y417_pho|​active@cSMAC

1. FYN:​HAVCR2|​pho@T_cell

1. BAG6:​HAVCR2@T_cell + FYN@T_cell → FYN:​HAVCR2|​pho@T_cell + BAG6@T_cell
2. FYN|​Y528_pho@cSMAC → FYN@T_cell
3. FYN@T_cell → FYN|​Y528_pho@cSMAC
4. FYN@T_cell → FYN|​Y417_pho|​active@cSMAC
5. FYN:​HAVCR2|​pho@T_cell → Regulation_of_T-cell_apoptosis@T_cell
6. FYN:​HAVCR2|​pho@T_cell → T-cell_anergy@T_cell
7. FYN@Cytosol → FYN|​pho@Cytosol
8. FYN|​pho@Cytosol → Miigration@Cytosol
9. Src family kinases*@Cytosol → FYN@Cytosol
10. FYN@INNATE_IMMUNE_CELL_Cytosol → FYN|​pho|​active@INNATE_IMMUNE_CELL_Cytosol

1. CD28@T_cell → CD28|​pho|​active@cSMAC
2. CD226@T_cell → CD226|​pho|​active@T_cell
3. WASP*@T_cell → WASP*|​Tyr291_pho|​active@T_cell
4. CD247:​CD3*:​alpha_/beta_TCR*@cSMAC → CD247|​pho:​CD3*|​pho:​alpha_/beta_TCR*@cSMAC + PTPRC@dSMAC
5. PAG1@T_cell → PAG1|​pho@T_cell
6. rIFNG@T_cell → IFNG@T_cell
7. FYN@T_cell → FYN|​Y417_pho|​active@cSMAC
8. TRAT1@cSMAC → TRAT1|​pho@cSMAC
9. PTPN11@Cytosol → PTPN11|​pho|​active@Cytosol
10. ARHGAP32@Cytosol → ARHGAP32|​Y_pho@Cytosol
11. VAV1@Cytosol → VAV1@Cytosol
12. CD247:​NKp30*@INNATE_IMMUNE_CELL_Membrane → CD247|​pho:​NKp30*@INNATE_IMMUNE_CELL_Membrane
13. CD247:​FCER1G:​NKp46*@INNATE_IMMUNE_CELL_Membrane → CD247:​CD247|​pho:​FCER1G:​NKp46*@INNATE_IMMUNE_CELL_Membrane
14. CD11a*:​CD18*:​DNAM1*|​pho@INNATE_IMMUNE_CELL_Membrane → CD11a*:​CD18*:​DNAM1*|​pho|​pho@INNATE_IMMUNE_CELL_Membrane
15. CRKL@INNATE_IMMUNE_CELL_Cytosol + PI3KR(p85)*@INNATE_IMMUNE_CELL_Cytosol → CRKL:​PI3KR(p85)*@INNATE_IMMUNE_CELL_Cytosol
16. SH2D1B@INNATE_IMMUNE_CELL_Membrane + in_s1747 → SH2D1B|​pho:​SLAMF7|​pho|​hm2@INNATE_IMMUNE_CELL_Membrane
17. DAP12*:​NKp44*@INNATE_IMMUNE_CELL_Membrane → DAP12*|​pho:​NKp44*@INNATE_IMMUNE_CELL_Membrane
18. SLAMF7@TUMOR_CELL_AS_INDUCTOR_Membrane + SLAMF7@INNATE_IMMUNE_CELL_Membrane → in_s5128