Reaction dissociation su_mpk1_mpk1_re30 map

BRAF|​pho:​GRB2:​KSR1:​MEK*|​pho|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map → BRAF|​pho:​GRB2:​KSR1-NTER*:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map + KSR1-CTER*:​MEK*@Cytoplasm map

Reaction regulators:
Catalysis
  1. Caspase3_sub_TRUNC_endsub_*@Cytoplasm map


References
KSR1 is cleaved by CASPASE3 in two regions: the C-ter region which mediates MEK binding and the N-ter region which contains the ERK binding site and the C1 domain required for plasma membrane localisation
PMID:17613518