Protein FGFR2 map

Identifiers
fibroblast growth factor receptor 2
"bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR
HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map

References
RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated.
PMID:17496910

Modifications:
In compartment: Cytosol
  1. FGFR2@Cytosol map
  2. FGFR2|​hm2|​active@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. FGFR family*@Cytosol map → map FGFR2@Cytosol map
    2. FGF family*|​hm2:​FGFR family*:​Heparin|​hm2@Cytosol map → map FGFR2|​hm2|​active@Cytosol map
    3. FRS2|​pho|​active@Cytosol map + FGFR2|​hm2|​active@Cytosol map + GRB2@Cytosol map + SOS*@Cytosol map → map FGFR family*:​FRS2|​pho@Cytosol map
    As Catalyser:
    1. FRS2@Cytosol map → map FRS2|​pho|​active@Cytosol map