Protein SHC1_p66_p52* map

Identifiers
SHC (Src homology 2 domain containing) transforming protein 1
HUGO:SHC1, HGNC:10840, ENTREZ:6464, UNIPROT:P29353 , GENECARDS:GC01M154934

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map

References
PMID:17673906
SHC1 gene has 3 corresponding protein isoforms: p66, p52 and p46
Upon TGFB stimulation, the activated TGFBR1 recruits and directly phosphorylates SHC1 (p66 or p52) on tyrosine and serine.
TGFB-induced SHC1 phosphorylation induces SHC1 (p66 or p52) association with Grb2 and Sos

SHC1_p66_p52*@Cytosol

References
em_emtc_emtc_re1272( EMT Senescence  map ):
PMID:17673906
Upon TGFB stimulation, the activated TGFBR1 recruits and directly phosphorylates SHC1 on tyrosine and serine.
TGFB-induced SHC1 phosphorylation induces SHC1 association with Grb2 and Sos
PMID:12767520
Upon IGF stimulation, the activated IGF1R recruits and directly phosphorylates SHC1, leading to cellular proliferation

SHC1_p66_p52*|​Y_pho|​S_pho|​active@Cytosol

References
em_emtc_emtc_re1272( EMT Senescence  map ):
PMID:17673906
Upon TGFB stimulation, the activated TGFBR1 recruits and directly phosphorylates SHC1 on tyrosine and serine.
TGFB-induced SHC1 phosphorylation induces SHC1 association with Grb2 and Sos
PMID:12767520
Upon IGF stimulation, the activated IGF1R recruits and directly phosphorylates SHC1, leading to cellular proliferation
em_emtc_emtc_re1275( EMT Senescence  map ):
In general, growth factor stimulation leads to the activation of receptor tyrosine kinases and to the phosphorylation of the receptor tail.
The resultant phosphotyrosines form docking sites for adaptator proteins (e.g. GRB2 via its SH2 domain).
The SH3 domain of adaptator (e.g. GRB2) then binds to the proline-rich motifs in the GTP exchange factor (i.e. GEF) for RAS (e.g. SOS)
Via this process that GEF (e.g. SOS) is recruited to the membrane where it colocalizes with and activates Ras.
SHC1 gene has 3 corresponding protein isoforms: p66, p52 and p46
Upon TGFB stimulation, the activated TGFBR1 recruits and directly phosphorylates SHC1 (p66 or p52) on tyrosine and serine.
TGFB-induced SHC1 phosphorylation induces SHC1 (p66 or p52) association with Grb2 and Sos

Modifications:
In compartment: Cytosol
  1. SHC1_p66_p52*@Cytosol map
  2. SHC1_p66_p52*|​Y_pho|​S_pho|​active@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. EGFR family*|​pho|​hm2:​SHC1_p66_p52*|​Y_pho|​S_pho@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. SHC1_p66_p52*@Cytosol map → map SHC1_p66_p52*|​Y_pho|​S_pho|​active@Cytosol map
  2. SHC1_p66_p52*|​Y_pho|​S_pho|​active@Cytosol map + em_s2285 + SOS*@Cytosol map + GRB2@Cytosol map → map EGFR family*|​pho|​hm2:​SHC1_p66_p52*|​Y_pho|​S_pho@Cytosol map
As Catalyser:
  1. em_emtc_emtc_s3418 → map em_emtc_emtc_s3009